АнГриКапс макси - instructions for use, doses, side effects, contraindications

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Dosage form: & nbspcapsules

Composition:

1 capsule contains:

Active substances:

paracetamol - 180 mg;

rimantadine hydrochloride 25 mg;

acid ascorbic with coating - type SC (SC - silicone coating) (in terms of ascorbic acid) - 150 mg;

loratadine - 1.5 mg;

rutozide - 10 mg;

calcium carbonate - 11.2 mg (in terms of calcium) - 4.48 mg

Excipients: calcium stearate - 4,5 mg, potato starch - 15 mg, lactose - a sufficient amount to obtain the contents of a capsule weighing 450 mg.

The composition of the gelatin capsule shell: gelatin pharmaceutical - 80.37 mg, glycerol - 0.413 mg, methyl parahydroxybenzoate - 0.355 mg, propyl parahydroxybenzoate - 0.086 mg, sodium lauryl sulfate - 0.058 mg, titanium dioxide - 1.354 mg, purified water - 12.99 mg, dyes: Quinoline yolkth E-104 0.079 mg, sunset sunsetth E-110 - 0.029 mg; The Diamond Facefight E-133 - 0.267 mg.

Description:

Hard gelatin capsules No. 0, yellow body and green lid. The contents of the capsules are light yellow with a greenish or cream shade powder.

Pharmacotherapeutic group:remedy for symptoms of acute respiratory disease and "colds"

ATX: & nbsp

Pharmacodynamics:

Pharmacological activity of the drug AnGrips max is due to the complex action of its components - paracetamol, rimantadine, ascorbic acid, loratadine, rutozide and calcium.

The drug has antiviral, antipyretic, analgesic, antihistaminic, angioprotective action.

Paracetamol has analgesic, antipyretic and weak anti-inflammatory effect.

Rimantadine antiviral agent, adamantane derivative. It is active against various strains of the influenza A virus. It suppresses the early stage of specific reproduction (after the virus enters the cell and before the beginning of transcription of RNA). Rimantadine inhibits the release of viral particles from the cell, i.e. interrupts the transcription of the viral genome. Ascorbic acid participates in many oxidation-reduction reactions, increases the body's resistance to infections.

Loratadin - blocker H1long-acting histamine receptors. Prevents the development of edema of the tissues associated with the release of histamine. It has antiallergic, antipruritic, antiexudative action.

Calcium - prevents the development of increased permeability and fragility of blood vessels, has a membrane-stabilizing effect.

Rutozid is an angioprotector.Prevents the development of increased permeability and fragility of the vessels that cause hemorrhagic processes in the flu. Rutozid together with ascorbic acid participates in oxidation-reduction processes, possesses antioxidant properties, prevents oxidation and promotes the deposition of ascorbic acid in tissues.

Pharmacokinetics:

The pharmacokinetics of the combined preparation has not been studied.

Indications:

Etiotropic and symptomatic treatment of influenza A in adults and children older than 14 years.

Symptomatic treatment of "cold" diseases, accompanied by pronounced influenza-like manifestations (fever, arthralgia, headache, intoxication) during the epidemic season for influenza.

Contraindications:

- hypersensitivity to one or notnumber of components that make up the preparation;

- pregnancy and lactation;

- age up to 14 years;

lactose intolerance, lactate defectglycose-galactose malabsorption.

Carefully:

renal and hepatic impairment;
nephrolithiasis;
benign hyperbilirubinemia (including Gilbert's syndrome);
viral hepatitis;
alcoholic liver damage;
elderly age;
epilepsy (including in the anamnesis);
sideroblastic anemia.

Dosing and Administration:

Inside, after eating, washed down with water.

Adults and children over 14 years of age are 2 capsules 2-3 times a day for 3-5 days, until the symptoms disappear disease.

If there is no improvement in reception drug should be discontinued and consult a doctor!

Side effects:

From the central nervous system: rarely - headache, fatigue, increased excitability, dizziness, tremor, hyperkinesia.

From the gastrointestinal tract: with a duration of intake of more than 7 days, damage to the mucous membrane of the stomach and duodenum, dyspepsia, dry mouth, nausea, anorexia, flatulence, diarrhea.

On the part of the blood system: with a duration of more than 7 days - agranulocytosis, leukopenia, thrombocytopenia, neutropenia, anemia.

Allergic reactions: rarely - skin rash, itching, hives are possible.

Overdose:

Symptoms: in the first 24 hours, paleness, nausea, vomiting and pain in the epigastric region, tremor, drowsiness, tachycardia, increased bilirubin in the blood, exacerbation of concomitant chronic diseases are possible.Symptoms of liver dysfunction may appear 12-48 hours after an overdose (paracetamol). In severe overdose - liver failure with progressive encephalopathy, coma, death; acute renal failure with tubular necrosis (including in the absence of severe liver damage); arrhythmia, pancreatitis.

Treatment: cause a gag reflex, gastric lavage, intake of adsorbents, symptomatic therapy.

It is necessary to consult a doctor.

Interaction:

If you need a joint intake with other medicines, consult a doctor beforehand.

It is recommended to avoid simultaneous use with glucocorticoid drugs, hepatotoxic and anticonvulsants, barbiturates, anticoagulants, rifampicin, alcohol.

Diflunisal increases the plasma concentration of paracetamol by 50% - the risk of developing hepatotoxicity.

Myelotoxic drugs increase the manifestation of hematotoxicity of the drug (paracetamol).

Metoclopramide increases the absorption of paracetamol when used together. Ascorbic acid increases the concentration in the blood of benzylpenicillin and tetracyclines; improves absorption in the intestine of iron preparations (converts trivalent iron into bivalent). Increases the risk of developing crystalluria in the treatment of salicylates and sulfonamides short-acting, slows the excretion of kidney acids, increases the excretion of drugs that have an alkaline reaction (including alkaloids), reduces the concentration of oral contraceptives in the blood. Reduces the therapeutic effect of antipsychotic drugs (neuroleptics) - phenothiazine derivatives, tubular reabsorption of amphetamine and tricyclic antidepressants.

Inhibitors CYP3A4 (incl. ketoconazole, erythromycin), inhibitors CYP3A4 and CYP2D6 (cimetidine and others) increase the concentration of loratadine in the blood.

The effect of rutoside is enhanced by ascorbic acid.

Calcium carbonate slows down the absorption of tetracyclines, digoxin, oral iron preparations (the interval between their doses should be at least 2 h). When combined with thiazide diuretics, it can increase hypercalcemia, reduce the effect of calcitonin in hypercalcemia, and reduce the bioavailability of phenytoin.

Special instructions:

Duration of application - no more than 5 days. During treatment, you should stop using alcohol-containing beverages (increased risk of gastrointestinal bleeding). With prolonged use (more than 7 days), the exacerbation of chronic comorbidity may be exacerbated, in elderly patients with hypertension, the risk of hemorrhagic stroke (due to rimantadine) is increased.

At admission, the risk of liver damage increases in patients with alcoholic hepatosis. Distorts the indicators of laboratory studies in the quantitative determination of glucose and uric acid in plasma (paracetamol).

In connection with the stimulating effect of ascorbic acid on the synthesis of glucocorticosteroid hormones, it is necessary to monitor the function of the adrenals and arterial pressure. Ascorbic acid as the reductant can distort the results of various laboratory tests (blood glucose, bilirubin, the activity of "liver" transaminases and lactate dehydrogenase).

Do not use if there are metastatic tumors.

Care must be taken when driving vehicles and engaging in other potentially hazardous activities requiring increased attention and speed of psychomotor reactions (contains rimantadine).

Form release / dosage:

Capsules.

Packaging:10 capsules in a planar cell package (blister pack), 2 contourcell packs (blisters) together with instructions for use in a pack of cardboard boxth.

Storage conditions:

Protected from moisture and light at a temperature of 15 to 25 ° C. Keep out of the reach of children.

Shelf life:

2 years. Do not use after the expiration date.

Terms of leave from pharmacies:On prescription

Registration number:LP-000288

Date of registration:17.02.2011

The owner of the registration certificate:MINSKINTERKAPS, UP MINSKINTERKAPS, UP Republic of Belarus

Manufacturer: & nbsp

MINSKINTERKAPS, UP Republic of Belarus

Information update date: & nbsp04.02.2016

Illustrated instructions

Instructions

AnGriCaps maximum (Angricaps maxima)