Antigrippin-ANVI® (Antigrippin-ANVI)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Dosage form: & nbspcapsules
Composition:

Capsule A.

Active substances: ascorbic acid - 300 mg, acetylsalicylic acid - 250 mg, rutoside trihydrate (in terms of rutozide) - 20 mg.

Excipients: calcium stearate - 1.0 mg, potato starch - 9.0 mg.

Capsule hard gelatinous:gelatin - 90,723 mg, azorubin (E 122) dye 0.003 mg, diamond black (E 151) 0.184 mg, blue patented E 131 colorant or brilliant blue colorant (E 133) 0.315 mg, quinoline yellow dye (E 104) - 2.207 mg, titanium dioxide (E 171) -2.560 mg.

Capsule B.

Active substances: metamizole sodium monohydrate 250 mg, calcium gluconate monohydrate 100 mg, diphenhydramine hydrochloride 20 mg.

Excipients: calcium stearate - 3.8 mg, potato starch - 6.2 mg. Capsule hard gelatinous: gelatin - 91.944 mg, titanium dioxide (E 171) - 4.055 mg.

Description:

Capsules A - Hard gelatinous No. 0 green. Contents of capsules A - a mixture of crystalline and amorphous powder from light yellow to yellow with a greenish tinge, it is allowed to have lumps.

Capsules B - Hard gelatinous No. 0 white. Contents of capsules B - a mixture of powder and granules white or white with a yellowish hue, it is allowed to have lumps.

Pharmacotherapeutic group:Remedy for elimination of symptoms of acute respiratory disease and "colds"
ATX: & nbsp
  • Other combined drugs used for catarrhal diseases
    • Pharmacodynamics:

    Combined drug.

    Acetylsalicylic acid has analgesic, antipyretic and anti-inflammatory action, inhibits platelet aggregation.

    Ascorbic acid plays an important role in the regulation of oxidation-reduction processes, carbohydrate metabolism, blood clotting, tissue regeneration, and improves the body's resistance.

    Rutoside (rutin) is an angioprotector. Reduces the permeability of capillaries, swelling and inflammation, strengthens the vascular wall. It inhibits aggregation and increases the degree of erythrocyte deformation.

    Metamizole sodium (analgin) has an analgesic, antipyretic and weak anti-inflammatory effect, the mechanism of which is associated with the inhibition of the synthesis of prostaglandins.

    Diphenhydramine (dimedrol) has antiallergic, decongestant, local anesthetic (reduces vascular permeability, eliminates edema and hyperemia of the nasal mucosa, perspiration in the throat, allergic reactions from the upper respiratory tract).

    Calcium gluconate is a regulator of calcium and phosphorus metabolism, has an antiallergic effect (the mechanism is unclear), reduces vascular permeability.For the treatment of allergic diseases or complications, its combined use with antihistamines is recommended.

    Indications:Symptomatic treatment in adults and children over 15 years of "colds", flu, ARVI.
    Contraindications:Hypersensitivity to the components of the drug; erosive ulcerative lesions (in the phase of exacerbation) of the gastrointestinal tract, gastrointestinal bleeding, increased tendency to bleeding, bronchial asthma, diseases accompanied by bronchospasm, "aspirin asthma," hematopoietic suppression (agranulocytosis, neutropenia, leukopenia), severe liver dysfunction or kidney, hereditary hemolytic anemia associated with a deficiency of glucose-6-phosphate dehydrogenase; hemorrhagic diathesis (hemophilia, von Willebrand's disease, telangiectasia, hypoprothrombinemia, thrombocytopenia, thrombocytopenic purpura), exfoliating aortic aneurysm, portal hypertension, hypercalcemia (calcium ion concentration should not exceed 12 mg% or 6 mEq / L), hypercalciuria, nephrolythiaz (calcium ); sarcoidosis, intoxication with cardiac glycosides (risk of arrhythmia); deficiency of vitamin K, deficiency of glucose-6-phosphate dehydrogenase.Pregnancy and the period of breastfeeding, children under 15 years.
    Carefully:Hyperuricemia, urate nephrolithiasis, gout, peptic ulcer and / or duodenal ulcer (in the anamnesis), decompensated heart failure.
    Dosing and Administration:

    Inside, after eating, with water, 2-3 times a day for 3-5 days until the symptoms disappear.

    Adults and children over 15 years of age are prescribed 2 capsules per reception: 1 green capsule (from blister A) and 1 white capsule (from blister B).

    If there is no improvement in the state of health, stop taking the medication and consult a doctor.

    Side effects:

    Anorexia, nausea, vomiting, gastralgia, diarrhea, erosive-ulcerative lesions of the gastrointestinal tract, gastrointestinal bleeding, hepatic and / or renal insufficiency, increased blood pressure, tachycardia. Allergic reactions: skin rash, Quincke's edema, bronchospasm.

    With prolonged admission (more than 7 days) - dizziness, headache, visual impairment, tinnitus, leukopenia, thrombocytopenia, agranulocytosis; with propensity to bronchospasm may provoke an attack; decrease in platelet aggregation, hypocoagulation, hemorrhagic syndrome (epistaxis, bleeding gums, purpura, etc.)kidney damage with papillary necrosis; deafness; anaphylactic shock, Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell's syndrome), Reye's syndrome in children (hyperpyrexia, metabolic acidosis, disorders of the nervous system and psyche, vomiting, liver dysfunction). There may be a violation of kidney function, oliguria, anuria, proteinuria, interstitial nephritis, staining of urine in red due to the release of a metabolite.

    All side effects (including those not mentioned above) should be reported to the doctor in charge and stop taking the drug.

    Overdose:

    Nausea, vomiting, pain in the stomach, sweating, pallor of the skin, tachycardia. With light intoxication - ringing in the ears; severe intoxication - drowsiness, collapse, convulsions, bronchospasm, shortness of breath, anuria, bleeding, progressive respiratory paralysis and dissociation of oxidative phosphorylation, causing respiratory acidosis.

    If you suspect a poisoning, you should immediately seek medical help.

    Treatment: cause vomiting, make a lavage of the stomach, take saline laxatives, Activated carbon. In the conditions of a medical institution - conducting forced diuresis, hemodialysis, with the development of convulsive syndrome - intravenous diazepam and barbiturates.

    Interaction:

    If it is necessary to share with other medications, consult a doctor beforehand.

    Enhances the effect of heparin, oral anticoagulants, reserpine, steroid hormones and hypoglycemic agents. Reduces the effectiveness of spironolactone, furosemide, antihypertensive drugs, anti-arthritis agents that promote the excretion of uric acid.

    Increases the side effects of glucocorticosteroids, derivatives of sulfonylurea, methotrexate, non-narcotic analgesics and non-steroidal anti-inflammatory drugs.

    Avoid combination of the drug with barbiturates, antiepileptics, zidovudine, rifampicin and alcohol-containing beverages (the risk of hepatotoxic effect increases).

    Ascorbic acid improves the absorption of iron in the intestine.

    Tricyclic antidepressants, contraceptives for oral administration and allopurinol disrupt metamizole metabolism in the liver and increase its toxicity.

    Metamizole enhances the effects of alcoholic beverages.

    Radiocontrast agents, colloidal blood substitutes and penicillin should not be used during metamizole treatment.

    Concomitant use of metamizol with cyclosporine reduces the level of the latter in the blood. Thiamazole and sarcolysin increase the risk of developing leukopenia.

    Sedatives and tranquilizers increase the analgesic effect of metamizol.

    Special instructions:

    The drug is not prescribed as antipyretic - children up to 15 years with acute respiratory diseases caused by viral infections, due to the risk of Reye syndrome (encephalopathy and acute fatty liver with the development of acute liver failure).

    With continued use of the drug, control of peripheral blood and the functional state of the liver is necessary. Because the acetylsalicylic acid has an antiaggregatory effect, the patient, if he is to undergo surgery, should warn the doctor in advance about taking the drug. Acetylsalicylic acid in low doses reduces the excretion of uric acid. This can in some cases provoke a gout attack.

    During treatment, you should stop using alcohol-containing beverages (increased risk of gastrointestinal bleeding).

    Acetylsalicylic acid has a teratogenic effect: when applied in the first trimester of pregnancy leads to malformations - the cleavage of the upper palate; in the third trimester - inhibition of labor (inhibition of the synthesis of prostaglandins), the closure of the arterial duct in the fetus, which causes hyperplasia of the pulmonary vessels and hypertension in the vessels of the small circulation. Acetylsalicylic acid is excreted in breast milk, which increases the risk of bleeding in the child due to impaired platelet function.

    In connection with the stimulating effect of ascorbic acid on the synthesis of corticosteroid hormones, it is necessary to monitor the kidney function and arterial pressure.

    Assigning ascorbic acid to patients with rapidly proliferating and intensely metastatic tumors can aggravate the course of the process. Ascorbic acid, as a reductant, can distort the results of various laboratory tests (blood glucose, bilirubin, activity of "liver" transaminases, LDH).

    In patients suffering from bronchial asthma and pollinosis, the development of hypersensitivity reactions is possible.

    During the period of drug use, one should refrain from active activities associated with the need for concentration of attention and increased speed of psychomotor reactions.

    Form release / dosage:Capsules.
    Packaging:

    Capsules A. 10 capsules per contour cell package.

    Capsules B. 10 capsules per contour cell package.

    2 contour cell packs (one with green capsules - contour cell A, the other with white capsules - a contourcell B) along with instructions for use in a pack of cardboard.

    Storage conditions:In a dry, protected from light place at a temperature of no higher than 25 ° C. Keep out of the reach of children.
    Shelf life:

    2 years.

    Do not use after the expiration date printed on the package.

    Terms of leave from pharmacies:Without recipe
    Registration number:P N000277 / 01
    Date of registration:10.10.2007 / 30.05.2016
    Expiration Date:Unlimited
    The owner of the registration certificate:Anvilab, OOO Anvilab, OOO Russia
    Manufacturer: & nbsp
    Representation: & nbspAnviLab Ltd AnviLab Ltd Russia
    Information update date: & nbsp06.09.2017
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