The frequency of side effects is presented in the following classification: very frequent (≥10%), frequent (≥1% and <10%), infrequent (≥0,1% and <1%), rare (≥0,01% and <0 , 1%), very rare (<0.01%).
In patients with benign prostatic hyperplasia there are the same side effects as in patients with hypertension, as well as:
From the side of the cardiovascular system: infrequent - marked reduction in blood pressure, orthostatic arterial hypotension, "hot flashes" of blood to the skin of the face.
From the central and peripheral nervous system: frequent - paresthesia, dry mouth, insomnia, increased excitability; infrequent - hypoesthesia, tremor, depression; very rare - priapism, impotence.
From the endocrine system: very rare - gynecomastia.
From the gastrointestinal tract: frequent - abdominal pain, diarrhea, dyspepsia, nausea; infrequent - flatulence, constipation, vomiting, loss of appetite.
On the part of the organs of hematopoiesis: very rare - leukopenia, thrombocytopenia.
From the hepatobiliary system: very rare - increased activity of "liver" transaminases, cholestasis, hepatitis, jaundice.
From the musculoskeletal system: infrequent - arthralgia, muscle cramps, weakness in the muscles, myalgia.
From the respiratory system: frequent - shortness of breath, rhinitis; infrequent - cough, nosebleeds; very rare - bronchospasm.
From the skin: infrequent - alopecia, skin rash, skin itch, purpura; very rare - hives.
From the sense organs: frequent - blurred vision; infrequent - noise in the ears, a syndrome of an atonic iris.
Co the side of the urinary system: infrequent - urination disorder, polyuria, urinary incontinence; very rare - dysuria, hematuria, nocturia.
From the side of the reproductive system: very rare - retrograde ejaculation.
From the immune system: very rare - anaphylactic reactions.
Other: infrequent - an increase in body weight, pain of varying localization.
Arterial hypertension
In clinical studies, orthostatic arterial hypotension was most often observed, especially at the beginning of treatment, which in rare cases can lead to fainting.
From the side of the cardiovascular system: frequent - peripheral edema.
From the central and peripheral nervous system: very frequent - dizziness, headache; frequent - drowsiness.
From the gastrointestinal tract: frequent - nausea.
From the respiratory system: frequent - rhinitis.
Other: frequent - asthenia, fatigue, malaise.
Patients with hypertension also had the following adverse reactions (cause-and-effect relationship not established): frequent - tachycardia, palpitation, chest pain; infrequent - angina pectoris, myocardial infarction, arrhythmia; very rare - bradycardia, impaired cerebral circulation.