Indomethacin - instructions for use, dose, side effects, contraindications

After oral administration, it is completely absorbed in the gastrointestinal tract. The maximum concentration in the blood plasma is reached after 2 hours. It binds to blood plasma proteins by 99% and accumulates in the focus of inflammation. Penetrates through the blood-brain and placental barrier, into breast milk. It is not removed during hemodialysis.

Metabolism in the liver.

The half-life is 4.5 hours.

Elimination by the kidneys (60%) and with feces (40%) in the form of metabolites.

Indications:

Used internally with chronic rheumatoid arthritis, psoriatic arthritis, Bechterew's disease, myositis, thrombophlebitis of superficial veins.As an adjuvant, it is used for inflammatory diseases of the ENT organs, prostatitis, cystitis, adnexitis, and also for analgesia with dysmenorrhea.

Used for topical application to prevent inflammation after surgical interventions for cataract and for inhibition of miosis.

It is applied externally for the treatment of articular syndrome, pain in the spine, neuralgia, myalgia, traumatic affection of joints and soft tissues.

ICD-10

VII.H25-H28.H25 Star cataract

VII.H25-H28.H26 Other cataracts

XIII.M05-M14.M05 Seropositive rheumatoid arthritis

XIII.M05-M14.M08 Juvenile [juvenile] arthritis

XIII.M05-M14.M10 Gout

XIII.M15-M19.M15 Polyarthrosis

XIII.M45-M49.M45 Ankylosing spondylitis

XIII.M50-M54.M54.1 Radiculopathy

XIII.M70-M79.M79 Other diseases of soft tissues, not elsewhere classified

XIII.M70-M79.M79.1 Myalgia

XIII.M70-M79.M79.2 Neuralgia and neuritis, unspecified

XIV.N30-N39.N30 Cystitis

XIV.N70-N77.N70 Salpingitis and oophoritis

XIV.N80-N98.N94.4 Primary dysmenorrhea

XIV.N80-N98.N94.5 Secondary dysmenorrhea

Contraindications:

Peptic ulcer of stomach and duodenum, violation of blood coagulation and hematopoiesis, hyperkalemia.

Individual intolerance to non-steroidal anti-inflammatory drugs and aspirin.

Carefully:

Children under the age of 12 with hyperthermia on the background of viral infections are a danger of developing Reye's syndrome. Chronic heart failure, active inflammatory processes of the liver, chronic renal failure, the use of diuretics. Hemophilia, systemic lupus erythematosus. Hypersensitivity.

Pregnancy and lactation:

Pregnancy and lactation: recommendations on the FDA - Category C. The use during pregnancy is contraindicated in the III trimester. In I and II trimesters, as well as during lactation indomethacin is prescribed in situations where the risk from taking the drug is lower than the expected efficacy.

Dosing and Administration:

Use in children

Inside to 2 mg / kg per day in 3 divided doses.

Adults

Inside: 25-50 mg 2-3 times a day.

Locally: in the form of ointment 2 times a day; to eliminate miosis in ophthalmic operations - 4 drops a day before the operation, and 4 drops 3 hours before the operation; with the goal of preventing postoperative edema - 1 drop 4-6 times a day.

The highest daily dose: 200 mg.

The highest single dose: 50 mg.

Side effects:

Central and peripheral nervous system: dizziness, agitation, headache, depression, cognitive disorders, sleep disorders, tremor, paresthesia, aseptic meningitis.

The cardiovascular system: arterial hypertension, tachycardia.

Hemopoietic system: leukopenia, thrombocythemia, agranulocytosis, aplastic anemia.

Digestive system: gastralgia, dyspeptic disorders, anorexia, melena, constipation.

Sense organs: diplopia, visual impairment, deafness.

urinary system: peripheral edema, proteinuria.

Allergic reactions.

Overdose:

Increased side effects, hyperventilation of the lungs, convulsive alertness.

Treatment is symptomatic.

Interaction:

Not compatible with alcohol.

Increases the concentration in the plasma digoxin, phenylalanine, lithium preparations.

Reduces the effectiveness of diuretics and antihypertensive drugs.

Increases the toxicity of methotrexate - recommended interval between taking drugs in 24 hours.

The concentration of the drug in the blood plasma is reduced with the simultaneous use of acetylsalicylic acid.

Changes the effect of oral hypoglycemic drugs: hypo- or hyperglycemia.

Special instructions:

It can slow down the reaction rate when driving vehicles and controlling machinery.

Instructions

Indomethacin (Indomethacinum)