Included in the formulation
АТХ:A.11.G.B.01 Ascorbic acid and calcium
Pharmacodynamics:It replenishes deficiency of calcium and ascorbic acid. Regulates the phosphorus-calcium metabolism.
Ascorbic acid is involved in the formation of collagen and in oxidation-reduction reactions, enhances reparative processes in tissues, improves cellular respiration.
Calcium stimulates the formation of bone tissue, participates in the processes of blood coagulation, stabilizes the cardiac activity, carries out the transmission of nerve impulses.
Pharmacokinetics:The tablet, dissolving in water, releases calcium citrate, which ensures that 35-40% of the ions are absorbed from the total amount of calcium.
Calcium is eliminated with feces, then, with saliva, kidneys.
Ascorbic acid is completely absorbed from the gastrointestinal tract after ingestion. It binds to plasma proteins in 25%. Normally, the concentration of ascorbic acid in the blood: 15-20 mcg / ml. The concentration of ascorbic acid in erythrocytes and plasma is lower than in platelets and leukocytes.
Ascorbic acid is oxidized to dehydroascorbic acid, metabolized to inactive ascorbate-2-sulfate and oxalic acid, then excreted in the urine.In cases of exceeding the dose (more than 200 mg) ascorbic acid is eliminated by the kidneys in an unchanged form.
Indications:It is used for calcium deficiency, for the prevention of hypovitaminosis C, especially during pregnancy and lactation. It is used for fractures of bones, asthenic conditions, and also for the complex treatment of allergic diseases.
IV.E50-E64.E54 Insufficiency of ascorbic acid
IV.E50-E64.E58 Alimentary calcium deficiency
XXI.Z70-Z76.Z73.0 Overwork
XXI.Z70-Z76.Z73.3 Stress condition, not elsewhere classified
Contraindications:Nephrolithiasis, chronic renal failure.
Stomach ulcer and duodenal ulcer.
Individual intolerance.
Pregnancy and lactation:Recommendations for FDA - group B. Used in pregnancy and lactation.
Dosing and Administration:The tablet dissolves in a glass of water, taken internally.
The highest daily dose: 2 tablets per day - adults, 1 tablet (for ½ two times) - for children from 4 to 12 years.
The highest single dose: 1 tablet for adults, ½ tablet - for children from 4 to 12 years.
Side effects:Possible diarrheal phenomenon: heartburn, nausea.
Allergic reactions.
Overdose:Headache, thirst, polyuria.
Treatment is symptomatic.
Interaction:Calcium interferes with the absorption of tetracycline antibiotics.
Thiazide diuretics increase the risk of hypercalcemia.
Fresh vegetable and fruit juices, alkaline drink - reduce the absorption of ascorbic acid in the gastrointestinal tract.
With the simultaneous use of the drug with acetylsalicylic acid, the efficiency is reduced by one third due to a decrease in absorption in the gastrointestinal tract.
Special instructions:The maximum dose of calcium during pregnancy should not exceed 1500 mg (3 tablets). Hypercalcemia can lead to defects in the mental and physical development of the fetus.