The cardiovascular system: development (aggravation) of symptoms of chronic heart failure (swelling of the ankles, stop, shortness of breath), violation atrioventricular conduction, arrhythmias, bradycardia, marked decrease in blood pressure, orthostatic hypotension, palpitations.
Central nervous system: dizziness, decreased ability to concentrate, slow reaction, drowsiness or insomnia, depression, hallucinations, fatigue, headache, weakness, nightmarish dreams, anxiety, confusion, or short-term memory loss, paresthesia in the extremities (in patients with intermittent claudication and Raynaud's syndrome), muscle weakness, convulsions.
Gastrointestinal tract: dry mouth, nausea, vomiting, diarrhea, abdominal pain, constipation, taste change.
Respiratory system: dyspnea, bronchospasm, apnea, nasal congestion.
Hematologic reactions: thrombocyte purpura, anemia (aplastic), thrombosis.
Endocrine system: decreased potency, decreased libido, hyperglycemia (in patients with non-insulin-dependent diabetes mellitus), hypoglycemia (in patients receiving insulin), hypothyroid status.
Skin reactions: urticaria, dermatitis, pruritus, photosensitivity, increased sweating, skin hyperemia, exacerbation of psoriasis, reversible alopecia.
Sense organs: impaired vision, decreased secretion of tear fluid, dryness and soreness of the eyes, conjunctivitis.
Influence on the fetus: intrauterine growth retardation, hypoglycemia, bradycardia.
Laboratory indicators: agranulocytosis, leukopenia, increased activity "hepatic" enzymes, hyperbilirubinemia.
Other: pain in the back, arthralgia, withdrawal syndrome (tachycardia, increased attacks of angina, increased blood pressure, etc.).
The frequency of side effects increases with an increase in the dose of the drug.