The cardiovascular system: development (aggravation) of symptoms of chronic heart failure (swelling of the ankles, stop, shortness of breath), violation of atrioventricular conduction, arrhythmias, bradycardia, marked decrease in blood pressure, orthostatic hypotension, palpitations.
Central nervous system: dizziness, decreased ability to concentrate attention, decreased reaction speed, drowsiness or insomnia, depression, hallucinations, fatigue, headache, weakness, nightmarish dreams, anxiety, confusion or short-term memory loss, paresthesia in the extremities (in patients with " intermittent "lameness and Raynaud's syndrome), muscle weakness, convulsions.
Gastrointestinal tract: dry mouth, nausea, vomiting, diarrhea, abdominal pain, constipation, taste change.
Respiratory system: dyspnea, bronchospasm, apnea, nasal congestion.
Hematologic reactions: thrombocytic purpura, anemia (aplastic), thrombosis;
Endocrine system: gynecomastia, decreased potency, decreased libido, hyperglycemia (in patients with insulin-dependent diabetes mellitus), hypoglycemia (in patients receiving insulin), hypothyroid status.
Metabolic reactions: hyperlipidemia.
Skin reactions: urticaria, dermatitis, itching, photosensitivity, increased sweating, skin hyperemia, exacerbation of psoriasis, reversible alopecia. Organs of the senses: impaired vision, decreased secretion of tear fluid, dryness and soreness of the eyes, conjunctivitis.
Influence on the fetus: intrauterine growth retardation, hypoglycemia, bradycardia. Laboratory indicators: agranulocytosis, leukopenia, increased activity of "hepatic" enzymes, hyperbilirubinemia.
Other: back pain, arthralgia, withdrawal syndrome (increased angina attacks, increased blood pressure).
The frequency of side effects increases with an increase in the dose of the drug.