Included in the formulation
АТХ:R.01.A.B.08 Tuamine Heptane
Pharmacodynamics:Acetylcysteine rapidly liquefies mucous and purulent-mucous discharge by rupturing the disulfide bonds of mucus glycoproteins. Acetylcysteine has an anti-inflammatory effect through the mechanism of inhibition of leukocyte chemotaxis, has antioxidant properties. Tuaminogeptan sulfate, sympathomimetic amine, with local application has a vasoconstrictive effect, eliminates edema, hyperemia of the mucous membrane.
Pharmacokinetics:With topical application of the drug, its constituent ingredients do not have a systemic effect.
Indications:Diseases of the nasal cavity and paranasal sinuses with the formation of a thick mucopurulent exudate (acute, subacute, chronic rhinitis, vasomotor rhinitis, sinusitis).
X.J00-J06.J00 Acute nasopharyngitis (runny nose)
X.J00-J06.J01 Acute Sinusitis
X.J30-J39.J30.0 Vasomotor rhinitis
X.J30-J39.J31.0 Chronic rhinitis
X.J30-J39.J32 Chronic Sinusitis
Contraindications:Hypersensitivity to one of the components of the drug, zakratougolnaya glaucoma, thyrotoxicosis.
Do not use during treatment and for 2 weeks after the end of treatment with antidepressants (monoamine oxidase inhibitors).
Carefully:With caution appoint the drug to children under the age of 3 years, patients with bronchial asthma, arterial hypertension, angina pectoris III-IV functional classes, frequent extrasystoles (treatment should be carried out under medical supervision).
Pregnancy and lactation:Action category for the fetus by Food and Drug Administration (US Food and Drug Administration) - not installed.
The use of the drug during pregnancy and during lactation is possible only in cases where the intended benefit to the mother exceeds the potential risk to the fetus and the baby.
Dosing and Administration:Intranasally. The drug is injected into the nasal cavity in the form of an aerosol using a special nebulizer.
Adults - 2 doses (2 pressure on the valve) in each nostril 3-4 times a day.
Children - 1 dose (1 pressure on the valve) in each nostril 3-4 times a day.
The course of treatment should not exceed 7 days.
Side effects:From the cardiovascular system: palpitation, tachycardia, arterial hypertension.
From the side of the central nervous system: rarely - excitation, tremor.
Local reactions: dryness of the mucous membrane of the nasal cavity, mouth and pharynx.
Other: rarely - allergic reactions, urinary retention, inflammation of the sebaceous glands.
With prolonged use of vasoconstrictors, it is possible to change the normal function of the mucous membrane of the nasal cavity and sinuses, as well as the development of addiction to the drug.
Overdose:Symptoms: Possible development of systemic side effects caused by thamine-heptane (tachycardia, tremor, anxiety, increased blood pressure, addiction).
Treatment: symptomatic.
Interaction:With the combined use of the drug with monoamine oxidase inhibitors and tricyclic antidepressants, the occurrence of systemic side effects caused by thamine-heptane increases (as these drugs enhance the effect of sympathomimetic drugs).
At simultaneous application the preparation can weaken the action of antihypertensive drugs.
The drug is incompatible with monoamine oxidase inhibitors and tricyclic antidepressants. It is not recommended simultaneous use with antihypertensive drugs - it is possible to weaken the antihypertensive effect.
Special instructions:It is used only intranasally.