Rinoflumucil® (Rinofluimucil®)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceAcetylcysteine ​​+ Tuamine HeptaneAcetylcysteine ​​+ Tuamine Heptane
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  • Rinoflumucil®
    spray nazal. 
    Zambon SpA     Italy
    • Dosage form: & nbspnasal spray
    Composition:100 ml of the solution contain the active substances: acetylcysteine ​​- 1.0 g, thiamine-heptane sulfate -0.5 g;
    Additional ingredients: benzalkonium chloride 0.01 g Hypromellose 0.75 g Disodium edetate 0.02 g Sodium dihydrogen phosphate 0.3 g, sodium hydrogen phosphate dodecahydrate 0.3 g, 0.1 g of dithiothreitol, 70% sorbitol 2.0 g peppermint flavoring 0.0188 g, ethanol 96% 0.31 g sodium hydroxide 0.36 g purified water to 100 ml.

    Description:Practically colorless transparent liquid with a characteristic mint slightly sulphurous smell.
    Pharmacotherapeutic group:Antitussive medication
    ATX: & nbsp

    R.01.A.B.08   Tuamine Heptane

    Pharmacodynamics:

    Rinoflumucil® has mucolytic, anti-edematous effects.

    Included in the drug acetylcysteine providing thinning effect and mucous-purulent mucus by breaking the disulfide bonds of the mucus glycoproteins. Acetylcysteine also has anti-inflammatory action (inhibition of leukocyte chemotaxis) and has antioxidant properties.

    Tuaminoheptane sulfate, a sympathomimetic amine, the local application has vasoconstrictor action, eliminates edema and hyperemia mucosa.

    Pharmacokinetics:When topically applied at recommended doses, the drug is not absorbed.
    Indications:

    Acute and subacute rhinitis with a thick purulent-mucous secretion, chronic rhinitis, vasomotor rhinitis, sinusitis.

    Contraindications:

    Rinoflumucil® is contraindicated in cases of hypersensitivity to one of the components of the drug, with closed-angle glaucoma, thyrotoxicosis. The drug should not be used during treatment and within 2 weeks after the end of treatment with tricyclic antidepressants and monoamine oxidase (MAO) inhibitors.

    Carefully:When the drug is prescribed for children (up to 3 years), patients with bronchial asthma, arterial hypertension, angina pectoris III-IV functional class, frequent extrasystole (treatment should be performed under the supervision of a doctor).
    Pregnancy and lactation:

    Application of the drug during pregnancy and lactation

    is possible only if the intended benefit to the mother exceeds the potential risk to the fetus or infant.

    Dosing and Administration:

    The drug is injected into the nasal cavity in the form of a spray with a special nebulizer.

    Adults: 2 doses of spray (2 pressure on the valve) in each nasal passage 3 4 times a day.

    Children: 1 dose of spray (1 pressure on the valve) in each nasal passage 3-4 times a day.

    Duration of treatment should not exceed 7 days.

    Do not exceed recommended doses and treatment without consulting your doctor.

    Spray Instructions

    1. Remove the cap from the solution vial.

    2. Remove the protective cap from the spray gun.

    3. Connect the nebulizer to the vial.

    4. Remove the cover from the spray gun.

    5. Activate the spray gun by pressing again.

    Side effects:

    In rare cases, allergic reactions, excitation, palpitation, tachycardia, tremor, arterial hypertension, urinary retention, dry mucous membrane of the nasal cavity, mouth and pharynx, inflammation of the sebaceous glands are possible.

    Long-term use of medications containing vasoconstrictor substances can alter the normal function of the nasal mucosa and paranasal sinuses, as well as causing addiction to the drug.

    Overdose:

    Symptoms: possible development of systemic side effects, caused by thiamine-heptane (tachycardia, tremor, anxiety, increased blood pressure, addiction).

    Treatment: symptomatic.

    Interaction:

    Rinoflumucil is incompatible with MAO inhibitors and tricyclic antidepressants,since the latter potentiate the action of sympathomimetic substances, and this can lead to the development of systemic side effects due to thiamine-heptane. With the simultaneous use of Rinoflumucil with antihypertensive agents, weakening of the antihypertensive effect is possible.

    Special instructions:

    Only for nasal administration.

    Effect on the ability to drive transp. cf. and fur:

    Rinoflumucil® does not affect the ability to manage vehicles and other mechanisms.

    Form release / dosage:

    Spray nasal.

    Packaging:

    10 ml in a glass vial of orange glass. For 1 bottle with a nebulizer and instructions for use in a pack of cardboard.

    Storage conditions:

    At a temperature of 15 to 25 ° C.

    Keep out of the reach of children.

    Shelf life:

    2.5 years. After opening the vial the contents can be used for 20 days.

    Do not use after the expiration date printed on the package.

    Terms of leave from pharmacies:Without recipe
    Registration number:П N012943 / 01
    Date of registration:11.07.2007
    The owner of the registration certificate:Zambon SpAZambon SpA Italy
    Manufacturer: & nbsp
    Representation: & nbspZAMBON SpA ZAMBON SpA Italy
    Information update date: & nbsp01.06.2012
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