If you suffer from hirsutism, and this disease has occurred recently or in Recently, significantly increased, It is necessary to inform about this doctor, because it is necessary to find out the cause of this phenomenon.
Data on estrogen / progestogen combinations such as Diane-35®, are based, mainly, on experience with the use of COCs. Consequently, the following caveats, related to the use of COCs, are also applicable to the drug Diane-35®.
- Thrombosis
Thrombosis - the formation of a blood clot, which can clog blood vessel.
The risk of developing venous and arterial thromboembolic complications maximum in the first year of admission of such preparations. Increased risk is present after the initial application of COC or renewal reception of the same or different COC (after a break between doses drug in 4 weeks or more). Data from a large prospective study with 3 groups of patients show that this increased risk is present, mainly,during the first 3 months.
The general risk of venous and arterial thromboembolic complications in patients, host low-dose COCs (<50 μg ethinylestradiol) are two to three times higher than those in patients who do not take COC and it remains lower compared to the risk of VTE on pregnancy and childbirth.
Very rarely, venous thromboembolism can lead to disability or death.
Thromboembolic complications (deep vein thrombosis, thrombophlebitis of the subcutaneous veins, thromboembolism of the pulmonary artery) may occur with any COCs.
Very rarely, when using COCs, thrombosis occurs in other blood vessels, for example, veins or arteries of the liver, mesenteric, renal, brain or retina.
The risk of thrombosis (venous and / or arterial) and thromboembolism increases with multiple or significant risk factors for venous or arterial thrombosis: - diseases of the vessels of the brain or coronary arteries of the heart.
- family history (ie, venous or arterial thromboembolism ever the close relatives or parents at a relatively young age); in the case of hereditary predisposition,a woman should be examined by an appropriate specialist to decide on the possibility of taking COCs;
- obesity (body mass index more than 30 kg / m2);
- subacute bacterial endocarditis;
- dyslipoproteinemia;
- arterial hypertension;
- migraine;
- heart valve diseases;
- atrial fibrillation;
- prolonged immobilization in cases of: large surgical operations, any operation on the lower limbs or extensive trauma. In these situations, it is advisable to stop taking the drug Diane-35 * (in the case of a planned operation, at least four weeks before) and not to resume reception within two weeks after the end of immobilization.
- Tumors The relationship between COC and cancer mammary gland is not proven, although women who take COC, he is detected somewhat more often than in women of the same age, they are not using. Perhaps this difference is caused by the fact that when taking the drug Women are more often breast cancer is detected in early stage. Increased risk gradually disappears after termination reception of these drugs.
In rare cases, against the background of sexual hormones liver tumors that can lead to life-threatening intraabdominal hemorrhages. Communication with the use of drugs has not been proven.
When suddenly a strong abdominal pain immediately consult a doctor.
Cervical cancer was detected several times more often in women who use COCs in for a long period of time. The connection with the reception of the COC has not been proved. This may be due to more frequent gynecological examinations to detect cervical disease or with peculiarities of sexual behavior (a more rare use of barrier methods of contraception). The most significant risk factor for developing cervical cancer is persistent papillomavirus infection.
Women with a tendency to chloasma while taking COC should avoid prolonged exposure to the sun and exposure ultraviolet radiation.
You should consider the increased risk of thromboembolism in the postpartum period. Violations peripheral blood circulation can also occur in diabetes mellitus, systemic lupus erythematosus, haemolytic-uremic syndrome, chronic inflammatory bowel diseases (Crohn's disease or ulcerative colitis) and sickle cell anemia.An increase in the frequency and severity of migraine during the use of COCs (which may precede cerebrovascular disorders) may be the reason for the immediate discontinuation of these medications.
Acyclic bleeding
As with the use of other COCs, when taking Diane-35® during the first few months, irregular vaginal bleeding may occur ("smearing" bleeding or "breakthrough" bleeding) in the intermenstrual period. Use hygiene products and continue to take the pills as usual. Irregular vaginal bleeding usually ceases as your body adapts to Diane-35® (usually after 3 cycles of taking the pills). If these disorders continue, become severe or resume after discontinuation, see a doctor.
Absence of the next menstrual like bleeding
If you took all the pills correctly, and you did not have vomiting in time of taking a pills or simultaneous reception of other medicinal drugs, the probability of pregnancy is small. Continue taking the drug Diane-35®, as usual.
If no two menstrualnopodobnyh bleeding in a row, immediately consult a doctor. Do not start taking the pills from the next package until the doctor excludes the pregnancy.
When necessary consult with a doctor
Regular inspections
If you are taking Diane-35 ®, The doctor will notify you regular inspections, which are usually a woman should go about 1 every 6 months.
Consult your doctor as as soon as possible:
- with any changes health, especially any states listed in this the leaflet (see also "Contraindications" and "Use with caution");
- for local compaction in the mammary gland; If you you intend to use other medicinal products (see "Interaction with other medicinal products ");
- if a prolonged immovability imposed gypsum), it is planned hospitalization or surgery (consult a doctor, at least 4-6 weeks before her);
- when an unusual severe bleeding from the vagina;
- if you forgot to take the pills in The first week of receiving the package and lived a sexual life in 7 days before;
- you twice did not have a contract the next menstrual bleeding or you suspect that you are pregnant (not start taking the pills from The next package, until consult a doctor).
Stop taking pills and consult a doctor immediately if you notice possible signs of thrombosis: symptoms of deep vein thrombosis (DVT): unilateral swelling of the lower limb or in the vein on the lower limb, pain or soreness in the lower limb only when standing or walking, feeling warm in the lower extremity, redness or change in the color of the skin on the lower limb.
Symptoms of pulmonary embolism (ELA): sudden unexplained shortness of breath or rapid breathing; sudden cough, including with blood; acute pain in the chest, which can intensify with a deep breath; sense of anxiety; severe dizziness; rapid or irregular heartbeat. Some of these symptoms (eg, "shortness of breath", "cough") are nonspecific and can be misinterpreted as signs of more or less severe conditions / diseases (eg, respiratory tract infection).Arterial thromboembolism can lead to stroke, vascular occlusion or myocardial infarction. Symptoms of stroke: sudden weakness or loss of face sensitivity, in the limbs, especially on one side of the body, sudden confusion, problems with speech and understanding; dizziness, loss of balance, or coordination of movements; sudden, loss of vision of one or two eye; sudden violation of gait, dizziness, loss of balance, or coordination of movements; sudden, severe or prolonged headache pain for no apparent reason; a loss consciousness or fainting with epileptic a fit or without it. Other signs of vascular occlusion: sudden Pain, swelling and mild blueing extremities, "sharp" abdomen.
Symptoms of myocardial infarction: pain, discomfort, pressure, heaviness, feeling compression or extension of the chest, arm or under the sternum; discomfort with irradiation in the back, cheekbone, throat, hand, stomach; cold perspiration, nausea, vomiting, or dizziness, severe weakness, anxiety or shortness of breath; rapid or irregular heartbeat.
The drug Diane-35® does not protect against HIV infection (AIDS) or any other sexually transmitted disease.
The drug Diane-35® is recommended by your doctor to you personally, do not pass the drug to others!