Intravenously, drip.
Dipeptiven is a concentrated solution not intended for direct administration. Before infusion, it must be mixed with a compatible carrier solution (0.9% sodium chloride solution, 5 % or 10% dextrose solution, or containing amino acids 10 % infusion solution).One volume part of Dipeptiven should be mixed with about five volume parts of carrier solution (for example, 100 ml of dipeptivene mixed with 500 ml of a 10% solution of amino acids).
In this case, the dose ratio of amino acids in 100 ml of Dipeptiven (20 g L-alanine-L- glutamine) and 500 ml carrier solution - 10 % solution of amino acids (50 g of amino acids) is 2: 5, which does not exceed the proportion of Dipeptivene in 30 % of the total number of amino acids introduced.
The choice of the central or peripheral vein for administration depends on the terminal osmolarity of the mixture.
Dipeptiven is intended for infusion into the central veins after addition to a compatible infusion solution.
Mixtures of solutions with osmolarity greater than 800 mOsmol / l should be introduced into the central veins.
Dosing regimen for adults and children.
The dose depends on the severity of the patient's hypercatabolic state and the need for amino acids.
With parenteral nutrition, the maximum daily dose is 2 g of amino acids / kg of body weight. When calculating the need, the addition of alanine and glutamine should be considered when Dipeptiven is administered.
The proportion of amino acids supplied by the administration of dipeptivene should not be approximately 30% of the total amount of amino acids introduced.
Daily dose
1,5 - 2,5 ml Dipeptivenen per kg body weight (equivalent to 0.3 - 0.5 g / kg N(2)-L-alanyl-L- glutamine). This corresponds to 100 -175 ml of Dipeptivenen per day for a patient weighing 70 kg.
The maximum daily dose:
2.5 ml / kg (equivalent to 0.5 g / kg N(2)-L-alanyl-L-glutamine). The maximum daily dose of 0.5 g / kg N(2)-L-alanyl-L-glutamine should be administered in combination with compatible amino acid solutions, providing approximately 1.0 g of amino acids / kg / day. As a result, the daily dose is approximately 1.5 g of amino acids / kg.
The following indicators are recommended when adding amino acids to the carrier solution:
- when the need for amino acids is 1.2 g / kg per day: 0.8 g / kg of amino acids with the addition of 0.4 g / kg N(2)-L-alanyl-L-glutamine;
- when the need for amino acids is 1.5 g / kg per day: 1.0 g / kg of amino acids with the addition of 0.5 g / kg N(2)-L-alanyl-L-glutamine;
- when the need for amino acids 2 g / kg per day: 1.5 g / kg of amino acids with the addition of 0.5 g / kg N(2)-L-alanyl-L-glutamine;
The infusion rate is determined by the infusion rate of the carrier solution and should not exceed 0.1 g of amino acids / kg / h.
Maximum concentration N(2)-L-alanyl-L-glutamine for therapeutic use is 3.5 %.
Duration of application - no more than 3 weeks. However, the experience of using Dipeptiven for more than 9 days is limited.
Indication, if necessary, of the characteristics of the action of the medicinal product at the first reception or at its cancellation
No data available.