According to the World Health Organization (WHO), adverse reactions are classified according to their frequency of development as follows:
Often (≥ 1/10),
often (≥ 1/100, <1/10),
infrequently (≥ 1/1000, <1/100),
rarely (≥ 1/10000, <1/1000) and
very rarely (<1/10000);
frequency unknown - According to available data to establish the frequency of occurrence was not possible.
On the part of the blood and lymphatic system
often: eosinophilia, suppression of platelet aggregation (only with infusion for several days).
From the side of metabolism and nutrition is very rare: hypokalemia.
From the nervous system often: headache.
From the side of the cardiovascular system
very often: increased heart rate ≥ 30 beats / min; often: increased blood pressure ≥ 50 mm of mercury. Art. (in patients with arterial hypertension may have a higher increase in blood pressure), lowering of blood pressure, ventricular arrhythmia, a dose-dependent increase in the number of ventricular extrasystoles,an increase in the frequency of ventricular contractions in patients with atrial fibrillation (prior to the initiation of therapy with dobutamine, such patients need to be digitized), vasoconstriction (especially in patients who previously received beta-adrenergic blockers), angina, palpitations.
Increased blood pressure by 10-20 mm Hg. Art. is observed in most patients.
infrequently: ventricular tachycardia, ventricular fibrillation;
very rarely: bradycardia, myocardial ischemia, myocardial infarction, stop
heart;
frequency unknown: decreased pressure in the pulmonary capillaries.
From the immune system
rarely: hypersensitivity reactions, bronchospasm.
Children's population
Adverse effects include increased systolic blood pressure, systemic hypertension or hypotension, tachycardia, headache and increased pulmonary wedge pressure, leading to congestion in the lungs and edema, as well as symptomatic complaints. A test of "stress echocardiography" with dobutamine
From the nervous system
often: headache;
frequency unknown: paresthesia, tremor, myoclonic seizures.
From the side of the cardiovascular system
very often: chest discomfort, ventricular extrasystole with a frequency> 6 / min;
often: supraventricular extrasystole, ventricular tachycardia; infrequently: ventricular fibrillation, myocardial infarction;
rarely: atrioventricular block of the second degree, spasm
coronary vessels, violation of blood pressure (hypertension / hypotension), occurrence of an intracavitary pressure gradient, a feeling of palpitations.
frequency unknown: stress-induced cardiomyopathy, fatal heart rupture.
On the part of the respiratory system, chest and mediastinum often:
bronchospasm, shortness of breath.
Mental disorders
frequency is unknown: anxiety, sensation of heat and anxiety.
From the gastrointestinal tract
often: nausea.
From the skin and subcutaneous tissues
often: exanthema;
very rarely: petechial bleeding.
From the side of the musculoskeletal system and connective tissue
often: chest pain.
From the side of the kidneys and urinary tract
often: mandatory urge to urinate.
General disorders and disorders at the site of administration
often: fever, phlebitis at the injection site, with insignificant
paravenous infiltration possible the development of local inflammation;
very rarely: cutaneous necrosis.