The incidence of adverse reactions described below was determined as follows: very often (≥1 / 10), often (≥1 / 100, <1/10); sometimes (≥1 / 1000, <1/100); rarely (≥1 / 10000, <1/1000); very rarely (<1/10000), including individual messages.
From the central nervous system: very often (especially at the beginning of the course of treatment) there are: increased fatigue, weakness, dizziness and headache; sometimes: decreased concentration of attention, slowed down the speed of mental and motor reactions, sleep disturbances, drowsiness, insomnia, nightmarish dreams, depression, tremors, convulsions, anxiety. Rarely: excitability, anxiety, paresthesia in the extremities (in patients with "intermittent" lameness and Raynaud's syndrome). Very rarely: short-term memory loss confusion and hallucinations, muscle weakness, asthenia, myasthenia gravis.
From the sense organs: rarely - reduced vision, reduced secretion of tear fluid, dry and painful eyes, conjunctivitis, tinnitus, hearing loss.
From the side of the cardiovascular system: often: excessive decrease in blood pressure, orthostatic hypotension (dizziness, sometimes loss of consciousness), increased heart rate, sinus bradycardia; rarely: a decrease in myocardial contractility, the development of heart failure (edema, edema of the feet and / or lower legs, shortness of breath), heart rhythm disturbances, manifestation of angiospasm (increased peripheral circulatory disturbance, coldness of the lower extremities, Raynaud's syndrome), impaired myocardial conductivity ,cardialgia; very rarely - aggravation of pre-existing AV conduction disorders.
From the digestive system: nausea, vomiting, abdominal pain, dry mouth, constipation or diarrhea, in some cases - impaired liver function (dark urine, icteric sclera or skin, cholestasis), changes in taste.
From the skin: increased sweating; rarely: rashes on the skin (exacerbation of psoriasis), skin hyperemia, exanthema, reversible alopecia; very rarely: photodermatosis, psoriasis-like skin reactions.
Allergic reactions: urticaria, skin itching, rash.
From the respiratory system: congestion of the nose, bronchospasm at the appointment in high doses (loss of selectivity and / or in predisposed patients), dyspnea.
Laboratory indicators: very rarely: thrombocytopenia (unusual bleeding and hemorrhage), agranulocytosis, leukopenia, increased activity of "liver" enzymes, hyperbilirubinemia.
From the endocrine system: a decrease in the level of high-density lipoprotein cholesterol and an increase in the triglycerides level (along with the normal level of total cholesterol), hyperglycemia (in patients with insulin-dependent diabetes mellitus), hypoglycemia (in patients receiving insulin), and hypothyroid status.
Influence on the fetus: intrauterine growth retardation, hypoglycemia, bradycardia.
Other: pain in the back or joints, weight gain, decreased libido and / or potency, with a sharp cessation of treatment - withdrawal syndrome (increased angina attacks, increased blood pressure).