Exostat - instructions for use, doses, side effects, contraindications

Excipients: isopropyl myristate 80.0 mg; polysorbate 60 - 61.0 mg; cetyl alcohol - 40.0 mg; stearyl alcohol - 40.0 mg; cetyl palmitate - 20.0 mg; sorbitan stearate (sorbitan monostearate) - 19.0 mg; benzyl alcohol - 10.0 mg; sodium hydroxide - 1.2 mg; purified water - up to 1.0 g.

Description:

Homogeneous or slightly grainy, shiny cream of white or almost white color, with a weak characteristic odor.

Pharmacotherapeutic group:antifungal agent

ATX: & nbsp

D.01.A.E.22 Naphthyfin

Pharmacodynamics:

Naphthyfine is an antifungal agent for external use that belongs to the class allylamines. The mechanism of action is associated with the inhibition of squalene-2,3-epoxidase, which leads to a decrease in the formation of ergosterol, which is part of the cell wall of the fungus.

Active against dermatophytes, such as Trichophyton, Epidermophyton, Microsporum, molds (Aspergillus spp.), yeast fungi (Candida spp., Pityrosporum) and other fungi (for example, Sporothrix schenckii). For dermatophytes and aspergillas naphthyline is fungicidal. Regarding yeast fungi naphthyline shows fungicidal or fungistatic activity, depending on the strain of the microorganism.

Has antibacterial activity against Gram-positive and Gram-negative microorganisms, which can cause secondary bacterial infections.

Has an anti-inflammatory effect, which contributes to the rapid disappearance of symptoms of inflammation, especially itching.

Pharmacokinetics:

With external application naphthyline well penetrates the skin, creating stable antifungal concentrations in its various layers. After applying systemic absorption to the skin, less than 6% of naphthyfine is exposed. The absorbed amount is partially metabolized and excreted by the kidneys and through the intestine. The half-life of naphthyfine is 2-3 days.

Indications:

- Fungal infections of skin and skin folds (tinea corporis, tinea inquinalis);

- interdigital mycoses (tinea manum, tinea pedum);

- fungal infections of the nails (onychomycosis);

- candidiasis of the skin;

- multicolored (lichen);

- dermatomycosis (with or without accompanying itching).

Contraindications:

- Hypersensitivity to naphthyfine, benzyl alcohol or other components of the drug;

- pregnancy and the period of breastfeeding (safety and efficacy not established).

Carefully:D(clinical experience is limited).

Pregnancy and lactation:

Application of the drug Exostat during pregnancy and during breastfeeding is contraindicated (the safety and efficacy of naphthyfine in this category of patients has not been studied).

Dosing and Administration:

Outwardly.

When skin is affected

The drug Exostat is applied once a day to the affected surface of the skin and the adjacent areas (approximately 1 cm of a healthy area of the skin along the edges of the affected area) after they have been thoroughly cleaned and dried.

Duration of therapy for dermatomycosis - 2-4 weeks (if necessary, up to 8 weeks), with candidiasis - 4 weeks.

When the nails are affected

The drug Exostat applied 2 times a day on the affected nail.Before the first use of the drug, remove the affected part of the nail with scissors or a nail file.

The duration of therapy with onychomycosis is up to 6 months.

To prevent recurrence, treatment should be continued for at least 2 weeks after the disappearance of clinical symptoms.

Side effects:

In some cases, local reactions can occur: dry skin, skin hyperemia (redness) and burning.

Side effects are reversible and do not require withdrawal of treatment.

If any of the side effects indicated in the manual are aggravated, or any other side effects not indicated in the instructions are noted, you should inform the doctor immediately.

Overdose:

No cases of overdose have been reported.

Interaction:

Interaction with other drugs has not been studied.

Special instructions:

The drug Exostat is not intended for use in ophthalmology. Do not allow the product to enter the eyes.

To achieve a therapeutic effect, course treatment is required.

Effect on the ability to drive transp. cf. and fur:

The drug Exostat does not adversely affect the ability to drive vehicles andperform other activities that require concentration and speed of psychomotor reactions.

Form release / dosage:

Cream for external use, 1%.

Packaging:

15 g or 30 g in an aluminum tube.

Each tube together with instructions for use in a pack of cardboard.

Storage conditions:

Store at a temperature not exceeding 25 ° C.

Keep out of the reach of children.

Shelf life:

3 years.

Do not use after expiry date.

Terms of leave from pharmacies:Without recipe

Registration number:LP-003654

Date of registration:30.05.2016

Expiration Date:30.05.2021

The owner of the registration certificate:VERTEKS, AO VERTEKS, AO Russia

Manufacturer: & nbsp

VERTEKS, AO Russia

Representation: & nbspVERTEKS CJSC VERTEKS CJSC Russia

Information update date: & nbsp23.07.2016

Illustrated instructions

Instructions

Exostat (Exostat)