Mikoderil®, solution for external use, 1% - antifungal agent, For external use, referring to the class of allylamines. Its active ingredient is naphthyline. The mechanism of action is related to inhibition of squalene-2,3-epoxidase, which leads to a decrease in the formation of ergosterol, which is part of the cell wall of the fungus. Naphthyfin, affecting squalene epoxidase, does not affect the cytochrome P-450 system.
Naphthyfin is active against dermatophytes, such as Trichophyton, Epidermophyton, Microsporum, yeast and yeast-like fungi (Candida spp., Pityrosporum), molds (Aspergillus) and other fungi (for example Sporothrix schenckii). For dermatophytes and aspergillas naphthyline is fungicidal. With regard to yeast fungi, the preparation shows fungicidal or fungistatic activity, depending on the strain of the microorganism. Naphthyfin has antibacterial activity against Gram-positive and Gram-negative microorganisms that cause secondary bacterial infections.