Increased individual sensitivity to the components of the drug, progressive systemic diseases (tuberculosis, leukemia, collagenosis, rheumatism, multiple sclerosis, AIDS, HIV infection, autoimmune diseases, widespread atherosclerosis),congenital intolerance to galactose, deficiency of lactase Lappa, glucose-galactose malabsorption.
The drug is not recommended for use in children under the age of 18 due to lack of data on efficacy and safety.