Phosphatidylcholine
More than 90% of the ingested phospholipids are absorbed into the small intestine. Most of them are cleaved by phospholipase A to 1-acetyl-lysophosphatidylcholine, 50% of which undergoes reverse acetylation to polyunsaturated phosphatidylcholine during absorption in the intestinal mucosa. Polyunsaturated phosphatidylcholine with a current of lymph enters the blood, from where it mainly enters high-density lipoproteins into the liver.
Pharmacokinetics in humans was studied with the help of dinolonelephosphatidylcholine with a radioactive label - 3H (choline part) and 14C (the rest of linoleic acid). Maximum concentration 3H is achieved in 6-24 hours, amounting to 19.9% of the prescribed dose; 14C in 4-12 hours, amounting to 27.9%. The half-life of the choline component is 66 hours, the remainder of linoleic acid is 32 hours. In the stool, a 2% 3H and 4.5% 14FROM; in urine 6% 3H and the minimum amount 14C. Both isotopes are absorbed in the intestine by more than 90%.
Glycyrrhizic acid
After oral administration in the intestine under the influence of the enzyme P-glucuronidase, produced by bacteria of normal microflora,from glycyrrhizic acid, an active metabolite is formed-P-glycyrrheic acid, which is absorbed into the systemic circulation. In the blood, P-glycyrrhetic acid binds to albumin and is almost completely transported to the liver. Isolation of P-glycyrrhotic acid occurs predominantly with bile, in the residual quantity - with urine.
According to experimental data, phospholipids improve the lipophilic properties of glycyrrhizic acid, increasing the intensity and speed of its absorption by more than 2 times.