Phosphogliv® (Phosphogliv®)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceGlycyrrhizic acid + PhospholipidsGlycyrrhizic acid + Phospholipids
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  • Phosphogliv®
    lyophilizate in / in 
    PHARMSTANDART-UFIM VITAMIN FACTORY, OJSC     Russia
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    • Dosage form: & nbsplyophilizate for the preparation of a solution for intravenous administration
    Composition:Per one vial:

    Active substances:

    Phospholipids (Lipoid C 100)

    - 0.50 g

    Trisodium salt of glycyrrhizic acid (sodium glycyrrhizinate)

    - 0.20 g

    Excipient:

    Maltose

    - 1.80 g
    Description:

    Lyophilized mass from white to light yellow color.

    Pharmacotherapeutic group:hepatoprotective agent
    ATX: & nbsp

    A.05.B.A   Preparations for the treatment of liver diseases

    Pharmacodynamics:

    Combined means. Has a membrane-stabilizing, hepatoprotective and antiviral effect.

    Phosphatidylcholine (the main component of phospholipids) is the main structural element of cellular and intracellular membranes, capable of restoring their structure and functions in damage, providing a cytoprotective effect.Normalizes protein and lipid metabolism, prevents the loss of hepatocytes of enzymes and other active substances, restores liver function, inhibits the formation of connective tissue, reducing the risk of fibrosis and cirrhosis of the liver.

    Glycyrrhizic acid has an anti-inflammatory effect, suppresses the reproduction of viruses in the liver and other organs by stimulating the production of interferons, increasing phagocytosis, increasing the activity of natural killer cells. Has a hepatoprotective effect due to antioxidant and membrane-stabilizing activity. Glycyrrhizic acid potentiates the action of endogenous glucocorticosteroids, providing anti-inflammatory and antiallergic effects in non-infectious liver lesions.

    When the skin is damaged due to the membrane-stabilizing and anti-inflammatory effect of the components, it limits the spread of the process and promotes regression of the disease.

    Indications:

    Viral hepatitis (acute and chronic), fatty liver degeneration (hepatosis), other liver damage (medicinal, alcoholic, toxic), liver cirrhosis, intoxications, psoriasis, neurodermatitis, eczema.

    Contraindications:

    Hypersensitivity to the components of the drug, pregnancy, lactation, children under 12 years.

    Dosing and Administration:

    Adults and children over 12 years.

    Intravenously, pre-dissolving the powder in 10 ml of water for injection. Intravenous administration is slow. Enter 10 ml daily 2 times a day in the morning and in the evening for 10 days, followed by a transition to oral administration of the drug in the form of capsules.

    The duration of the course can be increased on the recommendation of a doctor.

    Side effects:

    Perhaps the appearance of skin rashes (with increased individual sensitivity), which disappears after the drug is discontinued.

    If daily doses are exceeded, sodium and fluid retention, edema, increased blood pressure, hypokalemia may occur. When these symptoms appear, depending on their severity, it is necessary to reduce the dose of the drug and / or to prescribe spironolactone 50-100 mg per day.

    Interaction:

    The contents of the vial should not be mixed with other solutions. For dissolution use only water for injection. It is forbidden to use saline solution of sodium chloride or solutionglucose.

    Form release / dosage:

    Lyophilizate for the preparation of a solution for intravenous administration, 500 mg + 200 mg.

    Packaging:

    For 2.5 g of the drug in glass bottles, hermetically sealed with rubber stoppers, rolled with aluminum caps with a plastic component or capped with caps combined.

    Packaging of OJSC "Pharmstandard-Ufa Vitamin Plant" (OJSC "Pharmstandard-UfaVITA""):

    5 bottles of the drug complete with 5 ampoules (bottles) of water for injection of 10 ml are placed in a contour mesh package.

    One contour mesh package is placed in a pack of cardboard.

    Or for 5 or 10 bottles of the drug with instructions for use are placed in a pack of cardboard.

    Packing of the State Institution Scientific Research Institute of Biomedical Chemistry. V.N. Orekhovich RAMS:

    For 5 or 10 bottles with instructions for use are placed in a pack of cardboard.
    Storage conditions:

    In the dark place at a temperature of no higher than 20 ° C.

    Keep out of the reach of children.

    Shelf life:

    2 years.

    Do not use after the expiry date printed on the package.

    Terms of leave from pharmacies:On prescription
    Registration number:P N002528 / 02
    Date of registration:14.03.2008
    The owner of the registration certificate:PHARMSTANDART-UFIM VITAMIN FACTORY, OJSC PHARMSTANDART-UFIM VITAMIN FACTORY, OJSC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp22.12.2015
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