The frequency of side effects detected during the studies was evaluated as follows: very often (> 1/10), often (> 1/100, <1/10); infrequently (> 1/1000, <1/100).
In clinical studies of the drug Ganfort®, the following side effects were identified:
From the central nervous system: often - headache, dizziness.
From the side of the organ of vision: very often - congestion hyperemia, eyelash growth; often - superficial keratitis, corneal erosion, burning sensation, itching, burning pain in the eyes, foreign body sensation, dry eye mucosa, redness of the eyelids,pain in the eyes, photophobia, discharge from the eyes, impaired vision, itchy eyelid skin, decreased visual acuity, blepharitis, eyelid edema, irritation of the eye mucosa, epiphora; infrequently - iridocyclitis, edema of the conjunctiva, tenderness of the eyelids, asthenopia, trichiasis, hyperpigmentation of the iris, deepening of the fold of the eyelid, refraction of the eyelid; frequency unknown -cystoid macular edema.
From the respiratory system: often - rhinitis; infrequently - dyspnea; frequency unknown - bronchospasm (mainly in patients with existing bronchospastic disease).
From the skin and subcutaneous fat; often - skin pigmentation lawsuit, hirsutism, periocular hyperpigmentation skin.
Other side effects that were observed with the use of one of the components of the drug and potentially possible during the period of treatment with Ganfort®:
Bimatoprost
Infectious and parasitic diseases: infectious disease (catarrhal symptoms and symptoms of upper respiratory tract infection).
From the side of the organ of vision: allergic conjunctivitis, cataract, darkening of eyelashes, blepharospasm, retinal hemorrhage, uveitis, periorbital erythema, blurred vision.
From the cardiovascular system: increase in blood pressure.
General violations and changes in the place of introduction: asthenia, peripheral edema.
From the gastrointestinal tract: nausea.
Laboratory indicators: changes in the activity of liver enzymes.
Timolol
From the immune system: systemic allergic reactions, including Quincke's edema, hives, focal and multiple rashes, itching, anaphylaxis.
From the side of metabolism and nutrition: hypoglycemia.
Mental disorders: insomnia, depression, nightmarish dreams, memory loss.
From the central nervous system: syncope, acute impairment of cerebral circulation, increased symptoms of myasthenia gravis gravis, paresthesia, ischemia of the brain.
From the side of the organ of vision: decreased sensitivity of the cornea, diplopia, ptosis, detachment of the choroid (after operative treatment of glaucoma), keratitis, blurring of vision.
From the organ of hearing and the vestibular apparatus: noise in ears.
From the cardiovascular system: atrioventricular blockade, cardiac arrest, heart rhythm disturbances, loss of consciousness, bradycardia, cardiac insufficiency, congestive heart failure; decline arterial pressure, pain in a difficult cage, cerebrovascular accident, intermittent claudication, Raynaud's syndrome, cold extremities, palpitations, swelling.
From the respiratory system: bronchospasm (mainly in limes with episodes of bronchospasm in the anamnesis), dyspnea, cough.
From the gastrointestinal tract: perversion of taste, nausea, diarrhea, indigestion, dryness of the oral mucosa, abdominal pain, vomiting.
From the skin and subcutaneous fat: alopecia, psoriasis-like rashes, exacerbation of psoriasis, skin rash.
From the side of the musculoskeletal system and connective tissue: systemic lupus erythematosus, pain in the muscles.
From the urinary system: Peyronie's disease.
From the reproductive system and the breast: sexual dysfunction, decreased libido.
Others: asthenia / utomlavailability.