Heptor H (Heptor N)

Hepter H belongs to the group of hepatoprotectors, with antidepressant activity. It has choleretic and cholekinetic effect, detoxification, regenerating, antioxidant, antifibrozing and neuroprotective properties.

Replenishes the deficit of ademetionine and stimulates its production in the body, primarily in the liver and brain. Participates in biological reactions of transmethylation (methyl group donor) - molecule S-adenosyl-Lmethionine (ademethionine) donates a methyl group in the reactions of methylation of phospholipids of cell membranes of proteins, hormones, neurotransmitters, etc .; transsulfation - the precursor of cysteine, taurine, glutathione (provides redox mechanism of cellular detoxification), coenzyme acetylation. Increases the glutamine content in the liver, cysteine ​​and taurine in plasma; reduces the content of methionine in the serum, normalizing metabolic reactions in the liver. After decarboxylation it participates in aminopropylation processes as a precursor of polyamines-putrescine (stimulator of cell regeneration and proliferation of hepatocytes), spermidine and spermine, which are part of the ribosome structure.Has a choleretic effect due to increased mobility and polarization of hepatocyte membranes, due to stimulation of the synthesis of phosphatidylcholine in them. This improves the function of hepatocyte-associated transport systems of bile acids and promotes the passage of bile acids into the biliary system. Effective with intraloble variant of cholestasis (a violation of synthesis and current of bile). It contributes to the detoxification of bile acids, increases the content of conjugated and sulfated bile acids in hepatocytes. Conjugation with taurine increases the solubility of bile acids and their removal from the hepatocyte. The process of sulphation of bile acids contributes to the possibility of their elimination by the kidneys, facilitates the passage through the membrane of the hepatocyte and excretion with bile. In addition, sulfated bile acids protect the liver cells from the toxic effect of non-sulphated bile acids (in high concentrations present in hepatocytes with intrahepatic cholestasis).

In patients with diffuse liver disease (cirrhosis, hepatitis) with intrahepatic cholestasis syndrome reduces the severity of skin itching and changesbiochemical indicators, incl. the concentration of direct bilirubin, the activity of alkaline phosphatase, aminotransferases, etc. Choleretic and hepatoprotective effects persist up to 3 months after discontinuation of treatment. The efficiency is shown with hepatopathies due to hepatotoxic drugs. The appointment of patients with opioid addiction, accompanied by liver damage, leads to regression of clinical manifestations of abstinence, improvement of the functional state of the liver and the processes of microsomal oxidation. Antidepressant activity manifests itself gradually, beginning with the end of the first week of treatment and stabilizing within 2 weeks of treatment. Effective in recurrent endogenous and neurotic depressions resistant to amitriptyline. Has the ability to interrupt recurrence of depression. The appointment in osteoarthritis reduces the severity of the pain syndrome, increases the synthesis of proteoglycans and leads to partial regeneration of the cartilaginous tissue.