Pharmacological action - hepatoprotective, antidepressant, detoxifying, stimulating regeneration, antioxidant, neuroprotective.
Ademethionine (S-adenosyl-L-methionine) is a donor of methyl groups in the reactions of methylation of the phospholipids of cell membrane proteins, hormones, neurotransmitters (transmethylation). It is the physiological precursor thiol compounds - cysteine, taurine, glutathione (provides redox mechanism cellular detoxification), CoA and other reactions transsulfatirovaniya.. After decarboxylation it participates in aminopropylation processes as a precursor of polyamines -putrescine (stimulator of cell regeneration and proliferation of hepatocytes), spermidine and spermine, which are part of the ribosome structure.
Anticholestatic effect is due to the membrane-protective effect of the drug due to stimulation of the synthesis of phospholipids (phosphatidylcholine). This improves the function of the transport systems of bile acids (LC) and promotes the passage of the LC into the bile excretory system. Activates the conjugation of LC in hepatocytes. Conjugation with taurine increases the solubility of the LC and the elimination of them from hepatocytes.
Besides, ademethionine is the main source of methyl groups in the central nervous system. It mainly participates in the reactions of synthesis of biological polyamines, which play an important role in neuronal metabolism and nerve regeneration. Antidepressant action develops in the first week and stabilizes during the second week of treatment. It is effective in endogenous and neurotic depressions resistant to amitriptyline. Has the ability to interrupt recurrence of depression.