Heptor (Heptor)

Heptor belongs to the group of hepatoprotectors with antidepressant activity. Has choleretic and cholekinetic effect.Has detoxification, regenerating, antioxidant, antifibrozing and neuroprotective effect.

Replenishes the deficit of ademetionine and stimulates its production in the body, primarily in the liver and brain. Participates in biological reactions of transmethylation (a methyl group donor) - a molecule S-adenosyl-Lmethionine (ademethionine) donates the methyl group in the reactions of methylation of phospholipids of cell membranes, proteins, hormones, neutromediators, etc .; transsulfation - the precursor of cysteine, taurine, glutathione, (provides oxidation-reduction mechanism of cellular detoxification), coenzyme A. Increases glutamine content in the liver, cysteine ​​and taurine in plasma; reduces the content of methionine in the blood serum, normalizing metabolic reactions in the liver. After decarboxylation it participates in aminopropylation processes as a precursor of polyamines-putrescine (stimulator of cell regeneration and proliferation of hepatocytes), spermidine and spermine, which are part of the ribosome structure. Has a choleretic effect due to increased mobility and polarization of hepatocyte membranes due to stimulation of synthesis of phosphatidylcholine in them.This improves the function of hepatocyte-associated transport systems of bile acids and promotes the passage of bile acids into the biliary system. Effective with intraloble variant of cholestasis (a violation of synthesis and current of bile). It contributes to the detoxification of bile acids, increases the content of conjugated and sulfated bile acids in hepatocytes. Conjugation with taurine increases the solubility of bile acids and their removal from hepatocytes. The process of sulphation of bile acids facilitates their elimination by the kidneys, facilitates passage through the membrane of the hepatocyte and excretion bile. In addition, sulfated bile acids protect the liver cell membranes from the toxic effect of non-sulphated bile acids present in high concentrations in hepatocytes with intrahepatic cholestasis. In patients with diffuse liver disease (cirrhosis, hepatitis) with intrahepatic cholestasis syndrome reduces the severity of skin itching and changes in biochemical parameters, incl. concentration of direct bilirubin, activity of alkaline phosphatase, g-glutamyltranspeptidase, aminotransferases.Choleretic and hepatoprotective effects persist up to 3 months after discontinuation of treatment. Efficacy is shown for hepatopathies due to hepatotoxic drugs. The appointment of ademetionine to patients with opioid addiction, accompanied by liver damage, leads to regression of clinical manifestations of abstinence, improvement of the functional state of the liver and the processes of microsomal oxidation. Antidepressant activity manifests itself gradually, beginning at the end of 1 week of treatment and stabilizing within 2 weeks of treatment. Effective in recurrent endogenous and neurotic depressions resistant to amitriptyline. Has the ability to interrupt recurrence of depression. The appointment in osteoarthritis reduces the severity of pain syndrome, increases the synthesis of proteoglycans and leads to partial regeneration of cartilaginous tissue.