Hexo Bronho (Hexo Broncho)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceGuaifenesinGuaifenesin
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  • Hexo Bronho
    syrup inwards 
    Johnson & Johnson, LLC     Russia
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    • Dosage form: & nbspsyrup
    Composition:

    5 ml of syrup contain:

    active substance: guaifenesin - 100.0 mg;

    Excipients: levomenthol - 1.10 mg, glucose solution 3492.0 mg, sucrose 999.0 mg, ethanol 96% 0.2595 ml, glycerol 197.0 mg, sodium citrate 57.0 mg, sodium saccharinate 15, 0 mg, sodium benzoate 10.0 mg, citric acid monohydrate 12.0 mg, caramel dye 6.75 mg, natural sweetener 2.50 mg, raspberry flavor 2.28 mg, carbomer 974P 0.250 mg, reddish dye [Ponso 4R] - 0.250 mg, purified water - q.s. up to 5 ml.

    Description:Transparent liquid of red color with a characteristic smell, free from foreign inclusions.
    Pharmacotherapeutic group:Expectorant
    ATX: & nbsp

    R.05.C.A.03   Guaifenesin

    Pharmacodynamics:

    Guaifenesin has a stimulating effect on the receptors of the gastric mucosa, resulting in increased secretion of the glands of the gastrointestinal tract (GIT) and reflex increase in the secretion of respiratory tract glands. As a result, the viscosity decreases and the volume of bronchial secretion increases. Other effects may include stimulation of the endings of the vagus nerve in the bronchial glands and stimulationcertain centers of the brain, which, in turn, leads to improved sputum discharge. Guaifenesin exerts an expectorant effect within 24 hours.

    The components of the preparation have a warming, softening and soothing effect if swallowed.

    Pharmacokinetics:

    Guaifenesin is well absorbed from the digestive tract when ingested. In healthy adult volunteers, the maximum concentration in the blood (CmOh) and time to reach the maximum concentration in the blood (TSmOh) after ingestion of 600 mg of guaifenesin was approximately 1.4 μg / ml and 15 minutes, respectively. Half-life (T1/2) was about 1 hour, the drug was not detected in the blood after about 8 hours.

    Guaifenesin is metabolized in the liver. It is excreted mainly by the kidneys.

    Indications:Symptomatic therapy of cough accompanied by difficulty in sputum discharge.
    Contraindications:

    Hypersensitivity to any of the components of the drug, gastric ulcer and duodenal ulcer in the acute stage, children under 12 years. Breastfeeding period. Deficiency of sugar / isomaltase, intolerance to fructose,glucose-galactose malabsorption.

    Carefully:

    Pregnancy, severe impairment of liver or kidney function, diabetes mellitus.

    Pregnancy and lactation:

    Data on the use of the drug "Gekso Broncho" in pregnant women is not enough. Therefore, it is not recommended to use the drug during pregnancy, except when the expected benefit to the mother exceeds the potential risk to the fetus. Data on the penetration of guaifenesin into breast milk are not available, so for the period of treatment breastfeeding should be discontinued.

    Dosing and Administration:

    Inside. Adults and children over 12 years: fill the measuring cup to 10 ml and take 10 ml (200 mg guaifenesin) 4 times a day. The maximum daily dose is 40 ml (800 mg of guaifenesin).

    Side effects:

    Undesirable reactions identified during the post-marketing use of the drug were classified as follows: very frequent (≥1/10), frequent (≥1/100, <1/10), not frequent (≥1/1000, <1/100), rare (≥1/10000, <1/1000), very rare (< 1/10000), frequency unknown (frequency of occurrence can not be estimated on the basis of available data).

    Disorders from the gastrointestinal tract. Rarely: abdominal pain, diarrhea, nausea, vomiting.

    Impaired immune system. Rarely: reactions of hypersensitivity (including pruritus and urticaria), rash.

    Violations from the nervous system. Rarely: dizziness, headache, drowsiness.

    Overdose:

    Symptoms

    Symptoms of overdose are abdominal discomfort (heartburn, nausea, vomiting), drowsiness.

    Treatment

    Treatment is symptomatic and supportive.

    Interaction:

    It is not recommended simultaneous reception with antitussive drugs, including with codeine-containing drugs.

    Compatible with bronchodilators, antibacterial agents and other drugs used in the treatment of bronchopulmonary diseases.

    Special instructions:

    Do not take medication to treat persistent or chronic cough, cough with bronchial asthma and cough accompanied by excessive sputum secretion, except when recommended by a doctor.

    If after 3-5 days of taking the drug cough is preserved or along with a cough, fever, a rash, a prolonged headache, you should consult a doctor.

    Information for patients with diabetes: the content of carbohydrates in a single dose of the drug corresponds to 0.75 bread units (XE).

    The medicinal preparation "Hexo Broncho" contains ethanol 96% (0.5 ml / 10 ml syrup). The ethanol content should be considered for patients with alcoholism, women during pregnancy and breastfeeding, children and people at high risk, such as patients with liver disease, epilepsy, traumatic brain injury, brain diseases.

    The metabolite of guaifenesin can cause discoloration in the determination of 5-hydroxyindoleacetic acid and vanillylmandelic acid in the urine. The drug should be discontinued 24 hours before the urine collection for this analysis.

    If the medicinal product has become unusable or has expired, do not dispose of it in sewage and do not throw it out! Place the drug in a bag and put it in the trash. These measures will help protect the environment!

    Effect on the ability to drive transp. cf. and fur:

    During therapy with the drug "Gekso Broncho", care must be taken when driving vehicles and working withother technical devices that require a high concentration of attention and speed of psychomotor reactions, in connection with the possibility of developing dizziness and ethanol content.

    Form release / dosage:Syrup 100 mg / 5 ml.
    Packaging:

    For 150 ml of the drug in a vial of dark glass with a plastic screw cap with the control of the first opening, a system of protection from opening by children and with a schematic image of the opening of the vial. One bottle together with a plastic measuring cup and instructions for use in a cardboard bundle.

    Storage conditions:

    Store at a temperature not exceeding 25 ° C.

    Keep out of the reach of children.

    Shelf life:

    2 years.

    Do not use the product after the expiry date printed on the package.

    Terms of leave from pharmacies:Without recipe
    Registration number:LP-003887
    Date of registration:06.10.2016
    Expiration Date:06.10.2021
    The owner of the registration certificate:Johnson & Johnson, LLC Johnson & Johnson, LLC Russia
    Manufacturer: & nbsp
    Representation: & nbspJohnson & Johnson LLC Johnson & Johnson LLC Russia
    Information update date: & nbsp20.03.2017
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