Clinical and pharmacological group: & nbsp

Vasodilators

Included in the formulation
  • Instenon®
    solution in / in w / m 
    Nycomed Austria GmbH     Austria
  • Instenon®
    pills inwards 
    Nycomed Austria GmbH     Austria
  • АТХ:

    C.01.E.X   Other combination drugs for the treatment of heart disease

    Pharmacodynamics:

    Combined drug, improving metabolism and cerebral circulation.

    Heckbetidine

    Activates anaerobic glycolysis and pentose cycles, which are included in hypoxia and ischemia in the case of disturbances in the cycle of aerobic oxidative phosphorylation, thereby increasing the utilization of glucose and oxygen. The energy obtained by anaerobic glycolysis is used to synthesize and exchange mediators, restoration of synaptic transmission, the oppression of which, coupled with the destruction of synaptic membranes, leads to disorders of consciousness and neurological disorders associated with ischemia and hypoxia of the brain. The effect of the products of anaerobic glycolysis (lactate and pyruvate) on the receptor apparatus of intracranial arterioles and capillaries stabilizes the mechanisms of autoregulation of cerebral and cardiac blood flow.

    The etaman

    Normalizes the functional state of neural complexes of the cortex and subcortical-stem structures, activating the reticular formation.

    Theophilus

    Ethophylline activates myocardial metabolism, increases the minute volume of the heart, contributing to an increase in perfusion pressure in the vessels of the stem centers: vasomotor, respiratory, vegetovascular regulation, as well as the nuclei of the cranial nerves - primarily the wandering ones.

    In patients with closed cranial trauma, as well as with ischemic stroke, the disturbed consciousness is restored, regression of neurologic disorders occurs, and the autonomic nervous system is activated.

    Pharmacokinetics:

    Not studied.

    Indications:

    It is used for the treatment of brain diseases of the age and vascular nature, with the consequences of cerebral blood supply insufficiency, post-stroke states, as well as with vertigo caused by functional brain disorders.

    V.F00-F09.F01   Vascular dementia

    V.F00-F09.F07   Personality and behavioral disorders due to illness, damage or dysfunction of the brain

    VI.G40-G47.G45   Transitory transient cerebral ischemic attacks [attacks] and related syndromes

    IX.I60-I69.I67.2   Cerebral atherosclerosis

    IX.I60-I69.I69   Effects of cerebrovascular disease

    XVIII.R40-R46.R42   Dizziness and dizziness

    V.F00-F09.F07.1   Postencephalitis syndrome

    V.F00-F09.F07.2   Postcontasia syndrome

    VI.G40-G47.G46 *   Vascular cerebral syndromes in cerebrovascular diseases (I60-I67 +)

    IX.I60-I69.I63   Cerebral infarction

    IX.I60-I69.I67.9   Cerebrovascular disease, unspecified

    Contraindications:

    Convulsive syndrome, epilepsy, increased intracranial pressure (vomiting, prolonged headache, visual impairment), hemorrhagic stroke, individual intolerance, children under 18 years of age.

    Carefully:

    Stenosis of the carotid artery, a recent stroke.

    Pregnancy and lactation:

    Recommendations for FDA - Category C. Contraindicated in pregnancy and lactation.

    Dosing and Administration:

    Inside for 1-2 tablets (dosage: 20 + 50 + 60 mg) 3 times a day or 1 tablet (dosage of 60 + 100 + 60 mg) 3 times a day after or during meals. If necessary, the dose increases to 5 tablets per day (dosage of 60 + 100 + 60 mg) in several doses.

    Intravenously drip slowly 2 ml in 200 ml of 5% dextrose solution or 0.9% sodium chloride 1-2 times a day - with acute cerebral ischemia.

    Intramuscularly: 2 ml once a day.

    The duration of treatment is at least 6 weeks.

    The highest daily dose: 5 tablets (dosage of 60 + 100 + 60 mg).

    The highest single dose: 1 tablet (dosage of 60 + 100 + 60 mg).

    Side effects:

    Central and peripheral nervous system: headache.

    The cardiovascular system: arterial hypotension, reddening of the face, transient tachycardia with intravenous administration.

    Allergic reactions.

    Overdose:

    Increased side effects.

    Treatment is symptomatic - stopping intravenous infusion.

    Interaction:

    Enhances the effects of anticoagulants.

    Caffeine weakens the effect of the drug.

    Special instructions:

    In the treatment of patients, it is not recommended to drive vehicles and work with moving mechanisms.

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