Instenon® (Instenon® )

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceHeckbenzene + Etamivan + EthophillinHeckbenzene + Etamivan + Ethophillin
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  • Instenon®
    solution in / in w / m 
    Nycomed Austria GmbH     Austria
  • Instenon®
    pills inwards 
    Nycomed Austria GmbH     Austria
    • Dosage form: & nbspsolution for intravenous and intramuscular administration
    Composition:

    2 ml of solution contains:

    active substances: hexiodine dihydrochloride 10 mg, etamivan 50 mg, ethophylline 100 mg

    Excipients: disodium edetate 0.08 mg, propylene glycol 416.00 mg, water for injection up to 2.00 ml.

    Description:Transparent colorless liquid.
    Pharmacotherapeutic group:Vasodilator
    ATX: & nbsp

    C.01.E.X   Other combination drugs for the treatment of heart disease

    Pharmacodynamics:

    Instenon ® is a combined preparation that improves cerebral circulation and metabolism. Ethamane due to activation of the reticular formation normalizes the functional state of neural complexes of the cortex and subcortical-stem structures.

    Hecksbordin improves the utilization of glucose and oxygen by activating anaerobic glycolysis and pentose cycles (realized only under conditions of ischemia and hypoxia, when the cycle of aerobic oxidative phosphorylation is disrupted).

    Ethophylline activates myocardial metabolism, increases the minute volume of the heart, which increases the perfusion pressure in the vessels of the marginal zone of ischemia. This does not change the systemic blood pressure.Exciting effect on the nervous system is also manifested in the stimulation of subcortical formations, the midbrain, stem centers and nuclei (respiratory, vasomotor, centers of vegetative regulation, as well as the nuclei of cranial nerves, primarily the wandering ones).

    Pharmacokinetics:Special studies to study the pharmacokinetics of the drug Instenon ® was not conducted, due to the lack of necessary pharmacokinetic methods.
    Indications:Chronic insufficiency of cerebral circulation, post-stroke states, vertigo of central genesis.
    Contraindications:Pronounced agitation, convulsions, epilepsy, increased intracranial pressure, cerebral hemorrhage, hypersensitivity, pregnancy, lactation, children under 18 years.
    Carefully:Recently suffered stroke and stenosis of the carotid artery.
    Dosing and Administration:

    Depending on the severity of the condition 1-2 times a day for 1 ampoule intramuscularly, or intravenously slowly; or 1-2 times a day, one ampoule in the form of a dropwise infusion along with 250 ml of a 5% solution of glucose. As the condition improves, the treatment can be continued with oral forms of the drug (coated tablets).

    In some cases, rapid administration can lower blood pressure, so the duration of intravenous injection of one ampoule should be at least 3 minutes.

    Side effects:Headache, hyperemia of the face, lowering of arterial pressure, tachycardia (transient).
    Overdose:

    Symptoms: tachycardia, increased severity of side effects.

    Treatment: gastric lavage, Activated carbon, symptomatic therapy.

    Interaction:

    Strengthens the effect of antiplatelet agents (acetylsalicylic acid and etc.).

    Very high doses of caffeine can impair the action of Instenon® (large amounts of coffee and tea should be avoided).

    Special instructions:
    Effect on the ability to drive transp. cf. and fur:During the treatment period, care must be taken when dealing with potentially dangerous activities requiring increased concentration of attention and speed of psychomotor reactions.
    Form release / dosage:Solution for intravenous and intramuscular injection.
    Packaging:

    By 2.0 ml of the drug in colorless glass ampoules OPC type I EP with a fault point and three rings of gray, turquoise and gray.

    5 ampoules per polystyrene cell pack together with instructions for use in a cardboard bundle.

    Storage conditions:List B. At a temperature of 2-8 ° C, in a place protected from light. Keep out of the reach of children.
    Shelf life:3 years. Do not use after the expiration date.
    Terms of leave from pharmacies:On prescription
    Registration number:П N014738 / 01
    Date of registration:10.10.2008
    Expiration Date:Unlimited
    The owner of the registration certificate:Nycomed Austria GmbHNycomed Austria GmbH Austria
    Manufacturer: & nbsp
    Representation: & nbspNycomed Distribution Ltd.Nycomed Distribution Ltd.
    Information update date: & nbsp30.10.2017
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