Histochrome® (Histochrom®)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substancePentahydroxyethylnaphthoquinonePentahydroxyethylnaphthoquinone
Dosage form: & nbspinjection
Composition:

In 1 ml of the drug contains 0.2 mg of pentahydroxyethylnaphthoquinone as an active substance, excipients: sodium carbonate 0.08 mg, sodium chloride 0.9% solution 1 ml.

Description:Transparent liquid of red-brown color.
Pharmacotherapeutic group:Antioxidant
ATX: & nbsp

C.01.E.B   Other drugs for the treatment of heart disease

S.03.D   Other drugs for the treatment of eye and ear diseases

Pharmacodynamics:

Histochrome refers to antioxidant drugs. The mechanism of action is associated with the ability of histochrome to stabilize cell membranes, interact with the active forms of oxygen, free radicals, to exhibit the properties of a chelator of metals of variable valence. Histochrome reduces the amount of products of lipid peroxidation.

Pharmacokinetics:
Indications:

Adults in the complex therapy with the following ophthalmopathologies:

- dystrophic diseases of the retina and cornea, macular degeneration;

- primary open-angle glaucoma;

- diabetic retinopathy of the retina;

- vitreous hemorrhage, retina, anterior chamber;

- discirculatory disorder in the central artery and vein of the retina.

Contraindications:

Individual hypersensitivity to the components of the drug, children under 18 years.

Pregnancy and lactation:Safety of use during pregnancy and lactation is not established, so the drug is contraindicated in pregnancy and lactation.
Dosing and Administration:

In the form of subconjunctival and parabulbar injections, 0.3-0.5 ml of the solution 0.2 mg / ml daily or every other day. The course of treatment is 5-10 injections. If necessary the course of treatment is repeated after 3-4 months.

Side effects:Possible moderate pain after injection at the injection site, as well as local allergic reactions.
Overdose:Data on drug overdose are absent.
Interaction:

It is not allowed, when administered, to mix Histochrome with preparations containing proteins, calcium, iron salts.

Special instructions:
Form release / dosage:

Injection.

Packaging:

1 ml injection for 0.2 mg / ml in dark glass ampoules.

For 5 or 10 ampoules, along with instructions for the use of the drug, a knife or scarifier ampoule in a box of cardboard.

5 ampoules in a contour acrylic package made of polyvinyl chloride film. It is allowed to pack in a contour mesh box made of polyvinyl chloride film and foil or packaging material.

For 1 or 2 contour squares, together with the instruction for the use of the preparation, with a knife ampoule or scarifier ampullum in a pack of cardboard. When using ampoules with notch, or identification point or fault ring, the scarifier and knife ampoule is not embedded.
Storage conditions:

In the dark place at a temperature of 8 to 25 ° C.

Keep out of the reach of children.

Shelf life:

2 years.

Do not use the product after the expiry date printed on the package.

Terms of leave from pharmacies:On prescription
Registration number:P N002363 / 02
Date of registration:04.07.2008 / 26.02.2013
Expiration Date:Unlimited
The owner of the registration certificate:Pacific Institute of Bioorganic Chemistry FEB RAS Pacific Institute of Bioorganic Chemistry FEB RAS Russia
Manufacturer: & nbsp
Information update date: & nbsp24.04.2017
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