Histochrome® (Histochrom®)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substancePentahydroxyethylnaphthoquinonePentahydroxyethylnaphthoquinone
Dosage form: & nbspsolution for intravenous administration
Composition:

In 1 ml of the preparation contains 10 mg of pentahydroxyethylnaphthoquinone as an active substance. Excipients: sodium carbonate 4 mg, water for injection 1 ml.

Description:Opaque brownish-black liquid.
Pharmacotherapeutic group:Antioxidant
ATX: & nbsp

C.01.E.B   Other drugs for the treatment of heart disease

S.03.D   Other drugs for the treatment of eye and ear diseases

Pharmacodynamics:

Stabilizes the cell membranes, interacts with the active forms of oxygen, free radicals, shows the properties of the chelator of metals of variable valence. Histochrome reduces the amount of products of lipid peroxidation, the content of which increases with cardiovascular diseases. Has a cardioprotective effect in its use in patients with successful thrombolytic therapy of myocardial infarction.The use of histochrome leads to a decrease in the frequency of reperfusion arrhythmias, including life-threatening (ventricular extrasystoles IVa and - IVb classes, paroxysmal ventricular) and supraventricular tachycardia; does not have a significant effect on atrioventricular and intraventricular conduction. Histochrome slows the formation of necrosis in the first two or three days.

Additional to coronary thrombolysis, treatment with histochrome of patients with myocardial infarction improves myocardial contractility and reduces the incidence of acute left ventricular failure during the first day of the disease.
Pharmacokinetics:
Indications:Acute myocardial infarction in combination with thrombolytic drugs.
Contraindications:

Hypersensitivity to the components of the drug. Age to 18 years (effectiveness and safety not established).

Pregnancy and lactation:

Safety of use during pregnancy and lactation is not established, so the drug is contraindicated in pregnancy and lactation.

Dosing and Administration:

The drug is administered intravenously for at least 3 minutes.50-100 mg of the drug (1 or 2 ampoules of 5 ml of a solution at a concentration of 10 mg / ml) are dissolved immediately before administration in 20 ml of 0.9 % solution of sodium chloride. The same dose can be re-introduced within 24 hours. Administration of the drug is possible intravenously drip: 1 or 2 ampoules (50-100 mg of the drug) are dissolved in 100 ml of 0.9% sodium chloride solution.

Side effects:When intravenous drip infusion of histochrome may appear pain along the vein (without the development of phlebitis). In the first two days after the application of histochrome, urine was stained dark red. Allergic reactions are possible.
Interaction:

It is not allowed, when administered, to mix the histochrome solution with the preparations, containing proteins, calcium, iron salts.

Form release / dosage:Solution for intravenous administration.
Packaging:

5 ml of solution for intravenous administration of 10 mg / ml in ampoules of dark glass.

For 5 or 10 ampoules, along with instructions for the use of the drug, a knife or scarifier ampoule in a box of cardboard. By 5 ampoules in a contoured cell pack of a polyvinyl chloride film. It is allowed to pack in a contour mesh box made of a polyvinylchloride film and foil or packaging material.

For 1 or 2 contour squares, together with the instructions for use, a knife or scarifier ampoule in a pack of cardboard.

When using ampoules with notch, or identification point or fault ring, the scarifier and knife ampoule is not embedded.
Storage conditions:

In the dark place at a temperature of 8 to 25 ° C. Keep out of the reach of children.

Shelf life:

3 years.

Do not use the product after the expiry date printed on the package.

Terms of leave from pharmacies:On prescription
Registration number:P N002363 / 01
Date of registration:23.07.2008 / 12.08.2013
Expiration Date:Unlimited
The owner of the registration certificate:Pacific Institute of Bioorganic Chemistry FEB RAS Pacific Institute of Bioorganic Chemistry FEB RAS Russia
Manufacturer: & nbsp
Information update date: & nbsp24.04.2017
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