Glikodin - instructions for use, dose, side effects, contraindications

Active substanceDextromethorphan + Terpinhydrate + LevomentolDextromethorphan + Terpinhydrate + Levomentol

Similar drugsTo uncover

Glycodine

syrup inwards

Alembic Pharmaceuticals, Limited India

Dosage form: & nbspsyrup

Composition:

5 ml of syrup contain:

active substances: dextromethorphan hydrobromide 10 mg terpin hydrate 10 mg, 3.75 mg of levomenthol;

Excipients: 3250.00 mg of sucrose, 5.50 mg sodium methyl parahydroxybenzoate, propyl parahydroxybenzoate Sodium 2.75 mg citric acid monohydrate 0.85 mg propylene glycol 400.00 mg 600.00 mg glycerol, sodium saccharin 10.00 mg Caramel 65 00 mg, alem (BBA) 0.0165 mg, silicon purified qs, water purified to 5.0 ml.

Description:

The thick, viscous, opalescent liquid from yellow to dark yellow-brownish color with a characteristic smell.

Note. At low temperatures, an increase in the degree of opalescence is possible, which does not affect the quality of the preparation.

Pharmacotherapeutic group:Antitussive combined (antitussive opioid + expectorant)

ATX: & nbsp

R.05 Drugs used for cough and colds

Pharmacodynamics:

Dextromethorphan - antitussive drug, the strength of close to codeine, increases sensitivity threshold cough center of the medulla oblongata, suppresses cough of any nature, eliminates action of dry unproductive cough and well tolerated by all age groups.Has some sedative effect. Does not have analgesic, narcotic and hypnotic effects. Do not depress the respiratory center and the activity of the ciliated epithelium. The onset of action is 10-30 minutes after ingestion, duration - within 5-6 hours in adults and up to 6-9 hours in children.

Terpin hydrate has an expectorant effect; increases the secretory function of the epithelial glands of the respiratory tract, increases the secretion volume and reduces the secretion secretion secretion, protects the inflamed epithelial surface of the respiratory tract from direct contact with the external environment, which facilitates the acceleration of the recovery processes in the epithelium.

Levomenthol has a moderate antispasmodic effect. It alleviates the condition with the manifestation of symptoms of acute rhinitis, pharyngitis, laryngitis and bronchitis.

Pharmacokinetics:

After oral administration dextromethorphan completely absorbed in the gastrointestinal tract (GIT), metabolized in the liver. Time to reach the maximum concentration in the blood plasma - after 2 hours. Up to 45% of dextromethorphan can be excreted by the kidneys.

Terpin hydrate quickly absorbed from the digestive tract after ingestion.Part of the drug circulates in the blood in unchanged form and is excreted through the respiratory tract, with urine and sweat, giving the latter a specific odor. The other part of the drug is oxidized in the body and excreted by the kidneys in the form of phenols.

Levomenthol is excreted by the kidneys and with bile in the form of glucuronide.

Indications:

Acute and chronic diseases of the respiratory system, accompanied by a dry irritating cough.

Contraindications:

Hypersensitivity to one of the components of the drug, bronchial asthma, sugar / isomaltase deficiency, fructose intolerance, glucose-galactose malabsorption (due to the presence of sucrose), pregnancy, lactation period, children under 4 years.

Carefully:

Patients with impaired hepatic function.

Pregnancy and lactation:

Glikodin is contraindicated in pregnancy.

For the duration of treatment, breastfeeding should be discontinued.

Dosing and Administration:

Inside.

Adults: 1 teaspoonful (5 ml) 3-4 times a day.

Children from 4 to 6 years: 1/4 teaspoon 3-4 times a day; from 7 to 12 years - 1/2 a teaspoonful 3-4 times a day.

The course of treatment is recommended by a doctor.

Patients of advanced age. In the absence of violations of the kidneys should follow the usual dosage regimen.

Experience of application in patients with chronic renal failure (CRF) and / or moderate degree of hepatic insufficiency is limited.

Side effects:

Drowsiness, nausea, dizziness, itching, hives.

Overdose:

Symptoms: excitation, dizziness, respiratory depression, lowering of arterial pressure, tachycardia, dyspeptic disorders.

Treatment: artificial ventilation, symptomatic treatment. Specific antidote - naloxone, can be used for an overdose of 100 or more.

Interaction:

Strengthens the effect of narcotic antitussives and other drugs that depress the central nervous system.

It is potentially possible to interact with monoamine oxidase (MAO) inhibitors (taking dextromethorphan for the time of administration of MAO inhibitors is desirable to be excluded).

Special instructions:

When using the drug there is no development of addiction.

Terpin hydrate, which is part of the drug, gives the urine and sweat a specific odor, which has no clinical significance.

When taking the drug Glycodine syrup, patients with diabetes should take into account the sugar content in the syrup - 3250.0 mg sucrose, which is less than 1 bread unit (XE).

Features of the drug at the first admission or when it is canceled

There are no specific features of the action when the first reception or withdrawal of Glycodine is registered.

The actions of the doctor (paramedic), the patient with a missed intake of one or more doses of Glycodine

No special action by the doctor (paramedic) or the patient while skipping one or more doses of the drug is required.

Effect on the ability to drive transp. cf. and fur:

During the treatment period, care must be taken when driving vehicles and engaging in other potentially dangerous activities that require an increased concentration of attention and speed of psychomotor reactions.

Form release / dosage:Syrup.

Packaging:

To 50, 100 ml in bottles of dark glass with an aluminum screw cap or in bottles of polyethylene phthalate.

Each bottle together with a measuring cap made of polypropylene and instructions for use is placed in a cardboard pack.

Each bottle, together with a measuring cap made of polypropylene and instructions for use, is placed in a cardboard box.

Storage conditions:

Store in a dark place at a temperature of no higher than 25 °C. Do not freeze.

Keep out of the reach of children.

Shelf life:

3 years.

Do not use after the expiration date printed on the package.

Terms of leave from pharmacies:On prescription

Registration number:П N012064 / 01

Date of registration:25.05.2011 / 22.07.2014

Expiration Date:Unlimited

The owner of the registration certificate:Alembic Pharmaceuticals, LimitedAlembic Pharmaceuticals, Limited India

Manufacturer: & nbsp

Alembic Pharmaceuticals, Limited India

Representation: & nbspAlembic Pharmaceuticals, LimitedAlembic Pharmaceuticals, LimitedIndia

Information update date: & nbsp29.04.2017

Illustrated instructions

Instructions

Glycodine (Glycodin)