Combined drug.
Ibuprofen
Non-selectively suppresses COX1 and COX2, regulating the synthesis of prostaglandins. It indiscriminately suppresses synthetases of prostaglandins. Suppresses the production of anti-inflammatory cytokines. Violates the synthesis of arachidonic acid. Has analgesic, antipyretic and anti-inflammatory effect. Inhibits the aggregation of platelets. With long-term use has a desensitizing effect.
Codeine
Has antitussive and analgesic effect. Affects the μ-opiate receptors of the central nervous system, changes the emotional color of the pain syndrome, activates the antinociceptive (anesthetic) system, inhibits conditioned reflexes, raises the threshold of pain sensitivity, causes euphoria and drowsiness.
Increases the tone of the vagus nerve, suppresses cough center, activates the center of the oculomotor nerve, causing a narrowing of the pupil, increases the tone of the bronchi and smooth muscle sphincters of the intestine, bladder, bile ducts, weakens intestinal motility, reduces the secretion of the glands of the gastrointestinal tract.
Penetrates through the blood-brain and placental barrier, enters the breast milk.
With uncontrolled admission, addiction develops and drug dependence develops.
Caffeine
The alkaloid contained in coffee seeds, tea leaves, cola nuts, cocoa. Affects the content of intracellular calcium, adenosine receptors and phosphodiesterase, which destroys cAMP.
It inhibits the phosphodiesterase of cAMP, increasing its concentration in the brain tissues. Has psychostimulant activity, increasing mental and physical performance, reducing the need for sleep and removing the feeling of fatigue.
It stimulates the respiratory and vasomotor centers, having an analeptic effect. It inhibits the production of prolactin and the secretion of milk.
Metamizol sodium
Non-selectively suppresses COX1 and COX2, regulating the synthesis of prostaglandins. It indiscriminately suppresses synthetases of prostaglandins. Suppresses the production of anti-inflammatory cytokines. Violates the synthesis of arachidonic acid. Has analgesic, antipyretic and anti-inflammatory effect. Inhibits the aggregation of platelets. With long-term use has a desensitizing effect.
More analgesic effect, practically does not affect water-salt metabolism.
Phenobarbital
Increases the level of γ-aminobutyric acid - the inhibitory mediator of the central nervous system. Activates the monooxidase enzyme system, suppresses the stimulating effect of aspartate and glutamate on the central nervous system. In low doses, it has an antispasmodic and sedative effect. In high doses exhibits anticonvulsant and hypnotic action.