Pentafuphen® (Pentabufen®)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceIbuprofen + Codeine + Caffeine + Metamizol sodium + PhenobarbitalIbuprofen + Codeine + Caffeine + Metamizol sodium + Phenobarbital
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  • Pentafuphen®
    pills inwards 
    MOSCOW PHARMACEUTICAL FACTORY, CJSC     Russia
    • Dosage form: & nbsppills
    Composition:

    Each tablet contains:

    Active substances: analgin (metamizole sodium) - 300 mg ibuprofen - 200 mg, caffeine - 50 mg, phenobarbital - 10 mg of codeine phosphate (calculated as dry substance) - 8 mg or codeine (on dry substance) - 6mg or codeine base (in terms of dry matter) - 6 mg.
    Excipients: polyvinylpyrrolidone, medium molecular weight, lodipress, kollidon CL, talcum, calcium stearate.

    Description:

    Tablets from white with a slight yellowish tint to white with a yellow tint, weak specific smell, Valium chamfered and Valium.

    Pharmacotherapeutic group:analgesic non-narcotic remedy
    ATX: & nbsp

    N.02.B.B.72   Metamizole sodium in combination with psycholeptics

    Pharmacodynamics:

    "Pentabufen" - combined preparation having analgesic, antipyretic, anti-inflammatory action (due to the content metamizole and ibuprofen). Caffeine improves the health of patients, reduces drowsiness and fatigue, increases physical and mental performance. Phenobarbital increases the effectiveness of metamizole sodium and ibuprofen. Codeine has a central antitussive effect (by suppressing the excitability of the cough center), as well as an analgesic effect caused by excitation of opiate receptors in various parts of the central nervous system and peripheral tissues, leading to stimulation of the antinoceptive system and changes in emotional perception of pain.

    Pharmacokinetics:
    Indications:

    Pentabufen is used for moderate to severe pain syndrome of various origins (including pain in joints, muscles, radiculitis, neuralgia, headache, dental pain, migraine).

    Pentabufen is also used for the symptomatic treatment of "colds" and flu, reducing the fever.

    Contraindications:

    Hypersensitivity to ibuprofen or other components of the drug; severe violations of the liver and / or kidney function; Stomach ulcer and duodenal ulcers in the acute stage; chronic constipation; bronchial asthma, urticaria, rhinitis, provoked by the ingestion of acetylsalicylic acid (salicylates) or other NSAIDs; diseases of the optic nerve; violation of color vision, amblyopia,scotoma; oppression of hematopoiesis (agranulocytosis, cytostatic or infectious neutropenia); conditions accompanied by respiratory depression; increased intracranial pressure, craniocerebral trauma; hearing loss, pathology of the vetibular apparatus; arterial hypertension; pregnancy and the period of breastfeeding; children's age (up to 12 years).


    Carefully:peptic ulcer of the stomach and duodenum in remission, gastritis, enteritis, colitis; concomitant diseases of the liver and / or kidney; chronic heart failure; blood diseases of unclear etiology; A bronchial asthma, a urticaria, a rhinitis, polyps of a mucous nose; hyperbilirubinemia; hypothyroidism; elderly age.
    Pregnancy and lactation:
    Dosing and Administration:

    Inside. Adults and children over 12 years of age usually 1 tablet 1-3 times a day, washed down with water. The maximum daily dose is 4 tablets. The drug should not take more than five stumps as an anesthetic and more than three days as an antipyretic agent without prescribing and monitoring the doctor.

    If the symptoms persist for 2-3 days after taking the drug,it is necessary to stop treatment and consult a doctor
    Side effects:

    When using the drug for 2-3 days, side effects are almost not observed. In the case of prolonged use, the following side effects may occur:

    From the gastrointestinal tract: nausea, vomiting, heartburn, anorexia, a feeling of discomfort in the epigastrium, diarrhea, flatulence, impaired liver function.

    From the nervous system: headache, dizziness, hearing loss, tinnitus, insomnia, agitation, drowsiness, depression.

    From the cardiovascular system: heart failure, tachycardia.

    From the urinary system: edematous syndrome, impaired renal function.

    From the hematopoiesis: anemia, thrombocytopenia, agranulocytosis, leukopenia. Allergic reactions: skin rash, itching, urticaria, angioedema.

    Other: bronchospasm, respiratory depression, increased sweating.


    Overdose:

    Symptoms: abdominal pain, nausea, vomiting, retardation, drowsiness, depression, headache, tinnitus, narrowing of the pupil.

    Treatment: gastric lavage, the appointment of activated charcoal, alkaline drink, forced diuresis,symptomatic therapy.

    When respiratory depression, a specific antagonist-naloxone (narcan) is used.
    Interaction:It is not recommended simultaneous reception of Pentabufen tablets with acetylsalicylic acid and other NSAIDs. Tricyclic antidepressants, oral contraceptives, allopurinol increase the toxicity of metamizole sodium. Barbiturates, phenylbutazone and other inducers of microsomal liver enzymes weaken the action of metamizole sodium. Simultaneous use with cyclosporine reduces the level of the latter in the blood. Sedatives and tranquilizers increase the anesthetic effect of Pentafuphene.
    Reduces the effectiveness of uricosuric drugs, increases the effect of indirect anticoagulants, antiaggregants, fibrinolytics. Increases the side effects of mineralocorticoids, glucocorticoids, estrogens, ethanol. Antacids and colestramine reduce absorption. Increases the concentration in the blood of digoxin, lithium preparations, methotrexate. Do not use other drugs that contain non-narcotic drugs (acetylsalicylic acid, phenylbutazone, paracetamol etc.) and narcotic (morphine, promedol, buprenorphine, butorphanol, tramadol and others) analgesics. When taking the drug should not drink alcohol.
    Special instructions:

    With prolonged (more than 5 days) use of the drug, control of the picture of peripheral blood and the functional state of the liver is necessary. Taking the drug may make it difficult to diagnose an acute pain syndrome in the abdomen.

    Can change the results of tests of doping control athletes.

    If it is necessary to determine 17-ketosgerides, the drug should be discontinued 48 hours before the test.


    Effect on the ability to drive transp. cf. and fur:When taking Pentabufen it is necessary to refrain from driving motor vehicles and practicing potentially dangerous activities that require an increased concentration of attention and speed of psychomotor reactions.
    Form release / dosage:

    Pills.

    Packaging:10 tablets in a planar cell package; on 10 or 20 tablets in banks of dark glass. 1 or 2 contoured cell packs or a jar along with instructions for use are placed in a pack of cardboard.
    Storage conditions:

    List B. In dry, sheltered from light, at room temperature.

    Keep out of the reach of children!

    Shelf life:

    2 years.Do not use after the date shown on the package.

    Terms of leave from pharmacies:On prescription
    Registration number:LS-000069
    Date of registration:16.03.2010
    The owner of the registration certificate:MOSCOW PHARMACEUTICAL FACTORY, CJSC MOSCOW PHARMACEUTICAL FACTORY, CJSC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp29.05.2012
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