With the simultaneous use of indapamide with lithium preparations, an increase in the concentration of lithium in the blood plasma is possible.
Astemizole, erythromycin (with iv introduction), pentamidine, sultopride, wincamine, antiarrhythmic drugs Ia (quinidine, disopyramide) and III class (amiodarone, brethility, sotalol) increase the likelihood of heart rhythm disorders by type torsades de pointes (ventricular tachycardia of the "pirouette" type).
Non-steroidal anti-inflammatory drugs, glucocorticosteroids, tetracosactide, sympathomimetics reduce hypotensive effect, baclofen - Increases.
Saluretics, cardiac glycosides, gluco- and mineralocorticosteroids, tetracosactide, amphotericin B (with iv introduction), laxatives increase the risk of hypokalemia.
With simultaneous use with cardiac glycosides, the likelihood of developing digitalis intoxication increases, with calcium preparations - hypercalcemia, with metformin - possibly aggravation of lactic acidosis.
Combination with potassium-sparing diuretics can be effective in some patients, however, the possibility of hypo- and hyperkalemia, in patients with diabetes mellitus and renal insufficiency, is not completely excluded.
Angiotensin converting enzyme inhibitors increase the risk of arterial hypotension and / or acute renal failure (especially with existing renal artery stenosis).
Contrasting iodine-containing drugs in high doses increase the risk of kidney dysfunction (dehydration). Before using contrast iodine-containing drugs, patients need to restore fluid loss.
Tricyclic antidepressants and antipsychotic drugs increase the hypotensive effect and increase the risk of orthostatic hypotension.
Cyclosporine increases the risk of hypercreatininaemia.
Reduces the effect of indirect anticoagulants (coumarin or indanedione derivatives) due to an increase in the concentration of clotting factors as a result of a decrease in the volume of circulating blood and increase in their production by the liver (dosage correction may be required).
Strengthens the blockade of neuromuscular transmission, which develops under the action of dose).
Strengthens the blockade of the neuromuscular transmission, which develops under the action of nondepolarizing muscle relaxants.