The incidence of side effects is described in accordance with the following gradation: very frequent - more than 10%, frequent - from 1 to 10%, not frequent - from 0.1% to 1%, rare - from 0.01 to 0.1% very rare - less than 0.01%, unspecified frequency (according to available data, the incidence of side effects was not possible to establish).
From the side of the cardiovascular system:
very rare: marked decrease in arterial pressure, arrhythmia; unspecified frequency: arrhythmia of the type "pirouette" (possibly with a fatal outcome), an increase in the interval QT on the ECG.
From the nervous system:
rare: dizziness, fatigue, paresthesia, headache;
unspecified frequency: fainting.
From the digestive system:
infrequent: vomiting;
rare: nausea, constipation, dryness of the oral mucosa; very rare: pancreatitis, impaired liver function;
unspecified frequency: hepatic encephalopathy, hepatitis.
From the genitourinary system:
very rare: renal insufficiency.
From the skin and its derivatives:
Frequent: patchy-papular rash;
infrequent: purpura;
very rare: angioedema, toxic epidermal
necrolysis, Stevens-Johnson syndrome;
unspecified frequency: exacerbation of the systemic lupus erythematosus, photosensitivity reaction.
From the hematopoiesis:
very rare: thrombocytopenia, leukopenia, agranulocytosis, aplastic anemia, hemolytic anemia.
Laboratory indicators:
very rare: hypercalcemia;
unspecified frequency: hyperuricemia, hypochloraemia, hyponatremia accompanied by hypovolemia, dehydration and orthostatic hypotension (simultaneous loss of chloride ions can lead to compensatory metabolic alkalosis, however, the frequency of development of alkalosis and its severity is negligible), hypokalemia, hyperglycemia, glucosuria, increased activity of "liver" transaminases.