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Dosage form: & nbsppowder for solution for oral administration [cranberry, lime, forest berries, raspberry, mint]
Composition:

One-sachet composition

Active substances: paracetamol 350 mg, ascorbic acid 300 mg, succinic acid 120 mg, rutoside trihydrate (in terms of rutoside) 20 mg, phenylephrine hydrochloride 5 mg.

Excipients: cranberry flavors or lime flavors, or flavors of raspberry, or mint flavors - 60 mg, aspartame - 30 mg, giproloses - 30 mg, silicon colloidal dioxide - 10 mg, lactose monohydrate - 4075 mg.

Description:

The contents of the sachet are a mixture of powder and / or granules from light yellow to yellow with a greenish tinge color with the smell of cranberry or lime, or forest berries, or raspberries, or mint.

Solution after dissolving the contents of one sachet in 200 ml of water: cranberry - cloudy with a yellowish-greenish tinge, with the smell of cranberries. Presence of undissolved yellow particles;

lime - muddy with a yellowish-greenish tint, with the smell of lime. Presence of undissolved yellow particles;

forest berries - cloudy with a yellowish-greenish tinge, with the smell of forest berries. Presence of undissolved yellow particles;

crimson - cloudy with a yellowish-greenish tinge, with the smell of raspberries. Presence of undissolved yellow particles;

minty - cloudy with a yellowish-greenish tinge, with the smell of mint. Presence of undissolved yellow particles is allowed.

Pharmacotherapeutic group:ORZ and "colds" of symptoms remedy
ATX: & nbsp
  • Other combined drugs used for catarrhal diseases
  • Pharmacodynamics:

    Combined drug, has antipyretic, analgesic, angioprotective, anticongestive (anti-edematous) effect.

    Paracetamol has antipyretic, analgesic effect.

    Ascorbic acid (vitamin C) is involved in the regulation of carbohydrate metabolism, redox processes, the synthesis of steroid hormones, tissue regeneration, activates immune responses, reduces the permeability of capillaries, enhances detoxification of the liver, regulates blood clotting processes. It replenishes vitamin C deficiency with "cold" diseases.

    succinic acid strengthens biochemical and physiological recovery processes. Has hepatoprotective, immunomodulating and antioxidant effect. Activates energy processes in the mitochondria, normalizes the permeability of cell membranes, is an intermediate of the Krebs cycle.In combination with drugs enhances their positive effect and reduces the manifestation of toxic effects.

    Rutozid reduces permeability of capillaries, removes puffiness and inflammation, strengthens the vascular wall, inhibits aggregation and increases the degree of erythrocyte deformation.

    Phenylephrine stimulates postsynaptic alpha-adrenergic receptors, reduces edema and hyperemia of the nasal mucosa, restores free breathing, reduces pressure in the paranasal sinuses and the middle ear.

    Indications:Symptomatic treatment of "colds" and flu, accompanied by fever, headache, chills, nasal congestion, pain in the throat and nasal sinuses.
    Contraindications:

    If you have any of the following diseases or conditions, always consult a doctor before taking the drug.

    Increased individual sensitivity to one or more of the components included in the formulation; severe liver and kidney damage (acute hepatitis, acute pyelonephritis, acute glomerulonephritis, or exacerbation of chronic diseases of these organs); Stomach ulcer and duodenal ulcerintestines; glaucoma; propensity to thrombosis; diabetes; arterial hypertension, bradycardia, ventricular tachycardia, heart failure, conduction disorders, ventricular fibrillation, severe atherosclerosis, severe aortic stenosis, acute myocardial infarction; pheochromocytoma, hyperthyroidism, prostatic hyperplasia; simultaneous reception of tricyclic antidepressants, beta adrenoblockers, MAO inhibitors (and within 14 days after their cancellation), other medications containing paracetamol. Lactose intolerance, lactase deficiency, glucose-galactose malabsorption syndrome (due to the presence of lactose in the composition), phenylketonuria (due to the presence of aspartame). Pregnancy, the period of breastfeeding. Children under 18 years.

    Carefully:

    If you have any of the following diseases or conditions, always consult a doctor before taking the drug.

    Benign hyperbilirubinemia, congenital deficiency of glucose-6-phosphate dehydrogenase.

    Dosing and Administration:

    The drug is taken orally after a meal.To do this, it is necessary to dissolve the contents of one sachet in a glass of boiled hot water and take it hot. Stir the solution before use. Take one sachet in 4-6 hours, but no more than 4 times a day for 3 days. The maximum daily dose is 4 sachets.

    If within 3 days after receiving the drug did not come feel better, you should stop taking the drug and consult a doctor.

    Side effects:

    When used in recommended doses and duration, the drug is well tolerated, side effects develop extremely rarely.

    From the cardiovascular and circulatory systems: agranulocytosis (absence or marked decrease of granulocytes in peripheral blood), thrombocytopenia (low platelet counts), thrombocytosis (increasing the number of platelets) giperprotrombi-nemia (increase of prothrombin in the blood plasma) erythropenia (decreased red blood cell count), leukocytosis (increased number of leukocytes ), anemia (reduction of hemoglobin); increased blood pressure, bradycardia, arrhythmia, angina.

    From the nervous system and sensory organs: headache, agitation, irritability, restlessness, weakness, dizziness, respiratory depression, tremor (trembling). On the part of the intestine: nausea, vomiting, diarrhea (diarrhea).

    From the side of metabolism: metabolic disorders, suppression of glycogen synthesis, excessive formation of corticosteroids, sodium and water retention, hypokalemia (decrease in potassium content in blood plasma).

    From the genitourinary system: increased or decreased diuresis, damage to the glomerular apparatus of the kidneys, the formation of oxalate urinary stones.

    Allergic reactions: skin rash, hyperemia (redness) of the skin.

    If any of the side effects listed in the manual are aggravated, or if you notice any other side effects not listed in the instructions, tell your doctor.

    Overdose:

    Symptoms (an overdose is mainly caused by paracetamol): pallor of the skin, anorexia (lack of appetite), nausea, vomiting and abdominal pain, increased activity of "liver" transaminases, increased prothrombin time, hepatonecrosis, arrhythmia, ventricular tachycardia, increased blood pressure.

    Treatment: on a pre-hospital stage - washing of a stomach, reception of the activated coal. Symptomatic therapy. Antidote paracetamol - acetylcysteine.

    In case of overdose, see a doctor.

    Interaction:

    If you need to share with other medications, you should consult your doctor.

    Stimulants of microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites of paracetamol, which allows the development of severe intoxication with small overdoses.

    Paracetamol increases the effects of MAO inhibitors, sedatives, ethanol.

    Antidepressants, antiparkinsonian, antipsychotic drugs, phenothiazine derivatives increase the risk of urinary retention, dry mouth, constipation. Glucocorticosteroids increase the risk of developing glaucoma.

    Phenylephrine reduces the hypotensive effect of guanethidine.

    Guanethidine increases alpha-adrenostimulating effect, and tricyclic antidepressants - sympathomimetic effects of phenylephrine.

    Special instructions:

    The duration of the drug without consulting a doctor should not exceed 3 days.

    Distorts the results of laboratory tests evaluating the concentration of glucose and uric acid in the plasma.

    Persons prone to ethanol use should consult a doctor before starting treatment with the drug, since paracetamol can have a damaging effect on the liver.

    Form release / dosage:Powder for the preparation of solution for ingestion [cranberry, lime, forest berries, raspberry, mint].
    Packaging:5 g of powder for the preparation of a solution for ingestion of [cranberry] or [lime], or [forest berries], or [crimson] or [mint] in sachets, heat-sealing from packaging material combined on a paper basis or material of a foil-based aluminum . 3, 5, 6, 10, 16 or 50 bags together with instructions for use in a pack of cardboard.
    Storage conditions:

    In a dry place at a temperature of no higher than 25 ° C.

    Keep out of the reach of children.

    Shelf life:

    2 years.

    Do not use after the expiration date printed on the package.

    Terms of leave from pharmacies:Without recipe
    Registration number:LSR-003417/10
    Date of registration:23.04.2010 / 27.04.2017
    Expiration Date:Unlimited
    The owner of the registration certificate:Anvilab, OOO Anvilab, OOO Russia
    Manufacturer: & nbsp
    Information update date: & nbsp26.10.2017
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