Active substanceInterferon alfaInterferon alfa
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  • Dosage form: & nbsp
    lyophilizate for the preparation of solution for intranasal administration and inhalations
    Composition:

    1 ampoule contains active substance - interferon alpha - not less than 1000 ME.

    Characteristics of the preparation

    The drug is a group of proteins (interferons alpha), leukocytes synthesized by healthy donors, in response to the effects of the interferon inductor virus (Newcastle disease virus or Sendai virus). The drug does not contain preservatives and antibiotics.The surface antigen of the hepatitis B virus and antibodies to HIV 1, HIV 2, and hepatitis C virus are absent.

    Description:
    Porous amorphous mass or white powder or from light yellow to pink color, hygroscopic.
    Pharmacotherapeutic group:Cytokine
    ATX: & nbsp

    L.03.A.B.01   Interferon alfa

    Pharmacodynamics:Interferon alfa has the ability to stimulate the phagocytic activity of macrophages, as well as the cytotoxic activity of T cells and NK cells, has an indirect antiviral effect, inducing a state of resistance to viral infections in cells and modulating the response of the immune system, aimed at neutralizing viruses or destroying infected cells.
    Pharmacokinetics:Interferon is rapidly absorbed through the mucous membranes. It is excreted from the body in the form of natural metabolites.
    Indications:Prevention and treatment of influenza and other acute respiratory viral infections.
    Contraindications:Hypersensitivity to drugs of protein origin.
    Carefully:Persons with allergic diseases in history.
    Pregnancy and lactation:

    The safety of this medication during pregnancy and breastfeeding has not been investigated in controlled clinical trials.

    Therefore, the drug is used according to the doctor's prescription taking into account the ratio of expected benefits to the mother and the possible risk to the fetus and the baby.

    Dosing and Administration:

    Children with neonatal period (since birth) the drug is administered intranasally (by spraying or instillation). For children from 3 years old and adults - additionally in the form of inhalation.

    Intranasally

    The ampoule with the drug is opened immediately before use. Sterile distilled or cooled to room temperature boiled water is added to the ampoule to the dash indicated on the ampoule corresponding to 2 ml, gently shaken until the contents dissolve completely. Dissolved drug - a clear or slightly opalescent liquid, colorless or from light yellow to pink.

    The drug is used by instillation (using a medical pipette or syringe without a needle) or spraying. Spraying is carried out by sprayers of any system or by means of the attached nozzle-sprayer.

    For prevention The drug should be started with an immediate threat of infection and continue as long as the risk of infection persists. The drug is administered intranasally by instilling 5 drops or spraying 0.25 ml into each nasal passage 2 times a day with an interval of at least 6 hours.

    For treatment the drug is used at an early stage of the disease with the appearance of the first clinical symptoms intranasally in 0.25 ml (5 drops) in each nasal passage 1-2 hours at least 5 times a day. The effectiveness of the drug is higher the earlier its use has been started.

    Application rules for the nozzle-sprayer:

    1. Put the needle on the syringe, fill it with the dissolved drug in a volume of 0.25 ml (a mark of 10 on a scale of 40 units or a mark of 25 on a scale of 100 units).

    2. Remove the needle and firmly attach the spray nozzle.

    3. Bring the spray nozzle close to the nasal passage and squeeze the drug into the nasal passage with a sharp push on the syringe plunger.

    4. Remove the nozzle-sprayer, put on the needle and draw into the syringe 0.25 ml of the drug from the ampoule.

    5. Remove the needle, re-tighten the nozzle and inject the drug into the other nasal passage in accordance with paragraph 3.

    The spray nozzle is injected to a depth of 0.5 cm into the nasal passages, previously cleaned of mucus.The patient should be in a sitting position with a slightly tilted head and remain in this position for 1 minute after the administration of the drug. Only one patient can be used.

    Inhalation

    The most effective way to treat is inhalation. To conduct it, inhalers of any type are recommended. One procedure uses the contents of 3 ampoules, which is dissolved with 10 ml of water. Water is recommended to be heated to a temperature of no higher than 37 ° C. Inhalation, the drug is administered through the mouth and nose 2 times a day for 2-3 days.

    The introduction of the drug by injection is strictly prohibited!

    Side effects:Allergic reactions. If you notice any side effects not listed in the instructions, tell your doctor. With allergic reactions of immediate type, symptomatic therapy should be performed.
    Overdose:Cases of overdose are not described.
    Interaction:Applied in complex therapy with other drugs.
    Effect on the ability to drive transp. cf. and fur:
    Form release / dosage:Liofilizate for the preparation of solution for intranasal administration and inhalations, 1000 ME.
    Packaging:For 1000 ME in the ampoule. 10 ampoules with a knife or scarifier ampoule and instructions for use in a cardboard box (box) or 5 ampoules with a knife or scarifier ampoule, instructions for use, a spray nozzle for nasal use of drugs of a vertical type and a syringe with a needle in a cardboard bundle box) or 10 ampoules with a knife or scarifier ampoule, instructions for use, with two spray nozzles for nasal use of drugs of a vertical type in a cardboard box (box). When packing ampoules having a notch, a ring or break point, a knife or scarifier ampoule does not insert.
    Storage conditions:
    Store at a temperature of 2 to 8 ° C in a place protected from light and out of the reach of children.
    Shelf life:2 years. Do not use after the expiration date printed on the package.
    Terms of leave from pharmacies:On prescription
    Registration number:LS-001078
    Date of registration:13.07.2011 / 15.08.2013
    Expiration Date:Unlimited
    The owner of the registration certificate:MICROGEN FGUP Scientific and Production Association MICROGEN FGUP Scientific and Production Association Russia
    Manufacturer: & nbsp
    Information update date: & nbsp27.10.2017
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