Caxpal Neo - instructions for use, dose, side effects, contraindications

Composition of the film shell: colicoat® IR white II (polyethylene glycol 0.35 mg, polyvinyl alcohol 1.05 mg, copovidone (Coolin VA 64) 0.15 mg, titanium dioxide 0.44 mg, kaolin 0.37 mg, sodium lauryl sulfate 0.04 mg) 2.4 mg, colicoate® IR brilliant blue (polyethylene glycol - 0.09 mg, polyvinyl alcohol - 0.26 mg, copovidone (Colidone VA 64) -0.04 mg, titanium dioxide-0.05 mg, kaolin-0.09 mg, sodium lauryl sulfate-0.01 mg, brilliant blue-dye-0.06 mg) -0.6 mg.

Description:

Round, biconvex tablets, covered with a film coating of blue color; the core is white or almost white in cross section.

Pharmacotherapeutic group:Adaptogenic means (melatonin receptor agonist)

ATX: & nbsp

N.05.C.H.01 Melatonin

N.05.C.H Melatonin receptor agonists

Pharmacodynamics:

Coxpal Neo is a chemical analogue of the biogenic amine Melatonin. Chemical formula N-acetyl-5-methoxytryptamine. Molecular weight 232. Dissolves in water, alcohol, lipids. Well penetrates the blood-brain barrier. It is synthesized from amino acids of vegetable origin.

Pharmacological properties

It is a synthetic analogue of the hormone of the pineal gland (epiphysis). Normalizes circadian rhythms. Regulates the sleep-wake cycle, diurnal changes in locomotor activity and body temperature. Promotes the normalization of night sleep (speeds up sleep, improves sleep quality, reduces the number of nocturnal awakenings, improves well-being after a morning awakening, does not cause a feeling of sluggishness, weakness and fatigue when awakening, dreams become brighter and emotionally saturated).

Adapts the body to a rapid change of time zones, reduces stress reactions.

It shows immunostimulating and expressed antioxidant properties.

It inhibits the secretion of gonadotropins, to a lesser extent - other hormones of adenohypophysis - corticotropin, thyrotropin and somatotropin.

Does not cause addiction and dependence.

Pharmacokinetics:

When ingested quickly and completely absorbed, easily passes the histohematological barriers, including the blood-brain barrier. Has a short half-life.

Indications:

- As a hypnotic.

- as an adaptogen for the normalization of biological rhythms.

Contraindications:

Hypersensitivity, pronounced impaired renal function, autoimmune diseases, leukemia, lymphoma.

Allergic reactions, lymphogranulomatosis, myeloma, epilepsy, diabetes mellitus, chronic renal failure, pregnancy and lactation.

Pregnancy and lactation:

Pregnancy

There are no clinical data on the effects of melatonin on the course of pregnancy. Pre-clinical data do not indicate a possible adverse effect on the course of pregnancy, fetal development, the process of delivery, or the postnatal development of newborns. Due to the lack of clinical data, the use of melatonin during pregnancy and women planning a pregnancy,Not recommended.

Breast-feeding

Due to the fact that endogenous melatonin is defined in breast milk, probably exogenous melatonin can also penetrate into breast milk. Data obtained for animals, including rodents, sheep, cattle and primates, indicate the transfer of melatonin through the placenta or milk from mother to fetus. Therefore, the use of melatonin in the period of breastfeeding is contraindicated.

Dosing and Administration:

Inside. Adults on 1 / 2-1 tablet for 30-40 minutes before going to bed once a day.

As an adaptogen when changing time zones: 1 day before the flight and in the next 2-5 days for 1 tablet 30-40 minutes before bedtime. The maximum daily dose is up to 2 tablets per day.

Side effects:

There may be allergic reactions to the components of the drug, swelling in the first week of admission.

Headache, nausea, vomiting, diarrhea, morning drowsiness.

Overdose:

In case of accidental overdose: gastric lavage, symptomatic therapy. Increased severity of side effects.

Interaction:

Strengthens the effect of drugs that depress the central nervous system and beta-blockers.

It is not recommended to take together with hormonal drugs.

Incompatible with MAO inhibitors, glucocorticosteroids and cyclosporin.

Special instructions:

During the period of treatment, it is necessary to refrain from driving and practicing potentially dangerous activities that require an increased concentration of attention and speed of psychomotor reactions.

It is necessary to inform women who want to become pregnant, about the presence of a weak contraceptive effect in the drug.

Avoid bright lighting.

Effect on the ability to drive transp. cf. and fur:

Melatonin has a negative impact on the ability to drive vehicles and work with mechanisms, because may cause drowsiness. At the time of taking the drug Caxpal Neo, it is recommended to refrain from driving and handling machinery.

Form release / dosage:

Tablets, film-coated, 3 mg.

Packaging:

For 6, 10, 12 or 15 tablets in a contour mesh box made of polyvinyl chloride film and aluminum foil.

For 30 or 60 tablets in a jar or a plastic bottle with screw caps.

1 contour pack of 6, 10 or 12 tablets, or 2 contour packs of 12 or 15 tablets, or 3 contour packs of 10 tablets each, or 4 contour packs of 15 tablets, or 1 bank or a bottle of 30 or 60 tablets together with instructions for use in a pack of cardboard.

Storage conditions:

In a dry, the dark place at a temperature of no higher than 25 ° C. Keep out of the reach of children.

Shelf life:

3 years.

The drug should not be used after the expiry date indicated on the package.

Terms of leave from pharmacies:Without recipe

Registration number:LP-003799

Date of registration:19.08.2016

Expiration Date:19.08.2021

The owner of the registration certificate:PROFIT FARM, LLCPROFIT FARM, LLC Russia

Manufacturer: & nbsp

FARMZASCHITA NPC, FSUE Russia

Information update date: & nbsp27.11.2017

Illustrated instructions

Instructions

Coxpal Neo (Kakspal Neo)