Chloropyramin - instructions for use, dose, side effects, contraindications

Excipients: lactose monohydrate (sugar milk) - 130.0 mg, microcrystalline cellulose - 32.0 mg, sodium carboxymethyl starch 5.0 mg, povidone-K25 6.0 mg, magnesium stearate 2.0 mg.

Description:

round flat tablets of white or almost white color, without or almost odorless, with a cross-shaped risk on one side and chamfers on both sides.

Pharmacotherapeutic group:antiallergic - Irgistamine receptor blocker.

ATX: & nbsp

D.04.A.A.09 Chloropyramine

R.06.A. C.03 Chloropyramine

Pharmacodynamics:

Chloropyramine - a chlorinated analogue of tripelenamine (pyribenzamine) is an antihistamine drug belonging to the group of ethylenediaminic antihistamines.

Blocker H1-gistaminovyh receptors, has anti-histamine and m-cholinoblocking action, has antiemetic effect, moderate spasmolytic and peripheral cholinoblocking activity

Pharmacokinetics:When taken orally, it is almost completely absorbed from the gastrointestinal tract. The therapeutic effect of chloropyramine develops within 15-30 minutes after ingestion, reaches a maximum within the first hour after administration and lasts a minimum of 3-6 hours. It is well distributed in the body, including the central nervous system.

Indications:

Hives, serum sickness, seasonal and year-round allergic rhinitis, conjunctivitis, contact dermatitis, skin itching, acute and chronic eczema, atopic dermatitis, food and drug allergies, allergic reactions to insect bites.Angioedema (as an adjuvant).

Contraindications:

Hypersensitivity to chloropyramine and other components of the drug, pregnancy, lactation, children under 3 years of age, lactose intolerance, lactase deficiency or glucose-galactosia malabsorption, asthma attack.

Carefully:

Closed-angle glaucoma, urinary retention, prostatic hyperplasia, liver and / or kidney dysfunction, peptic ulcer disease, cardiovascular diseases, elderly patients, depleted patients, respiratory failure, simultaneous administration of monoamine oxidase (MAO) inhibitors and other drugs , depressing the central nervous system.

Pregnancy and lactation:

Chloropyramine is contraindicated in pregnancy.

If it is necessary to use the drug during lactation, the question of stopping breastfeeding

Dosing and Administration:

Inside, with food, without chewing and washing down with enough water.

Adults and adolescents with 14 years of age - 25 mg (1 tablet) 3-4 times a day (75-100 mg per day).

Children aged 3 to 6 years - 6.5 mg (1/4 tablets) 3 times a day or 12.5 mg (1/2 tablet) 2 times a day.

Children aged 6 to 14 years - 12.5 mg (1/2 tablets), the frequency of reception - 2-3 times a day. Special patient groups: Patients with impaired hepatic function: may require a dose reduction due to a decrease in the metabolism of the active component of the drug in liver diseases.

Patients with impaired renal function: it may be necessary to change the regimen of the drug and reduce the dose due to the fact that the active the component is mainly excreted through the kidneys.

The duration of the course of treatment depends on the symptoms of the disease, its duration and course.

Side effects:

- From the central nervous system (CNS): drowsiness, weakness, fatigue, dizziness, headache, nervous excitement, tremor, euphoria, movement coordination disorders, seizures, encephalopathy.

- On the part of the organs of the gastrointestinal tract: discomfort in the abdomen, pain in the upper abdomen, dryness of the oral mucosa, nausea, vomiting, diarrhea, constipation, loss or increase in appetite.

- From the cardiovascular system: lowering blood pressure, tachycardia, arrhythmia.

- From the side of the organ of vision: blurred vision, glaucoma, increased intraocular pressure.

- From the hematopoiesis side: leukopenia, agranulocytosis, hemolytic anemia and other pathological changes in the cellular composition of the blood.

- Other: difficulty urinating, urinary retention, muscle weakness, photosensitivity, allergic reactions.

If side effects occur, stop taking the medication and seek medical advice immediately.

Overdose:

Symptoms: children - excitement, anxiety, hallucinations, athetosis, movement coordination disorder, convulsions, dryness of the oral mucosa, fixed dilated pupils, facial hyperemia, sinus tachycardia, urinary retention, fever, then vascular collapse, coma. In adults - inhibition, anxiety, impaired coordination of motion, depression, hyperthermia and hyperemia of the skin, psychomotor agitation, convulsions, post-convulsive depression, coma.

Treatment: in the period up to 12 hours after taking the drug, gastric lavage is necessary, (it should be borne in mind that the anticholinergic effect of the drug prevents the emptying of the stomach).The use of activated carbon is shown (during detoxification in the early periods after oral administration). It is necessary to control the parameters of blood pressure and respiration. Symptomatic therapy (including the appointment of antiepileptic drugs, caffeine), resuscitation, artificial ventilation - according to the indications. There is no specific antidote.

Interaction:

MAO inhibitors can enhance and prolong the anticholinergic action of chloroniramine. Potentiates the effect of medicines for general anesthesia, hypnotics, sedatives, tranquilizers, analgesics (including opioid), local anesthetic, atropine, simnagolitikov, barbiturates, M-anticholinergics. Simultaneous use with ethanol is not recommended (risk of severe CNS depression). Tricyclic antidepressants enhance m-cholinoblocking and inhibitory effect on the central nervous system. Caffeine reduces the inhibitory effect on the central nervous system. Antihistamines may interfere with the manifestation of the reaction in the formulation of skin allergy samples, so a few days before the planned test of the administration of drugs of this type should be discontinued. Chloropyramine can mask the signs of complications likely in the treatment of ototoxic drugs in case of their simultaneous application.

Special instructions:

When combined with ototoxic drugs chloropyramamine can mask the early signs of ototoxicity. Disease of the liver and kidneys may require a change (decrease) in the dose of the drug. Taking the drug at night can increase the symptoms of reflux esophagitis. The simultaneous use of ethanol (alcoholic beverages) is inadmissible. Long-term use of antihistamines may lead to violations of hematopoiesis (leukopenia, agranulocytosis, thrombocytopenia, hemolytic anemia). If an unexplained increase in body temperature occurs during long-term use of the drug, laryngitis, pale skin, jaundice, ulceration in the mouth, the appearance of hematomas, unusual and prolonged bleeding, it is necessary to perform an analysis to determine the number of blood elements. If the results of the analysis indicate a change in the blood formula, the drug is stopped.

Effect on the ability to drive transp. cf. and fur:

Chloropyramine, especially in the initial period of treatment, can cause drowsiness, fatigue and dizziness. Therefore, in the initial period, the duration of which is determined individually, it is prohibited to drive vehicles or perform work associated with an increased risk of accidents. After that, the degree of restriction on driving and the work with the mechanisms of the doctor should be determined for each patient individually.

Form release / dosage:

Tablets 25 mg.

Packaging:For 10, 20 tablets per contour cell pack of film polyvinylchloride and foil aluminum printed varnished.

For 10, 20. 30, 40, 50, 60 or 100 tablets in cans of polyethylene terephthalate or in polymer cans for medicines.

One jar or 1, 2, 3, 4, 5, 6 or 10 contour squares, together with the instructions for use, are placed in a cardboard package (bundle).

Storage conditions:In the dark place at a temperature of no higher than 25 ° C. Keep out of the reach of children

Shelf life:3 years. Do not use after expiration date

Terms of leave from pharmacies:Without recipe

Registration number:LP-002922

Date of registration:20.03.2015

The owner of the registration certificate:ATOLL, LLC ATOLL, LLC Russia

Manufacturer: & nbsp

OZONE, LLC Russia

Information update date: & nbsp28.09.2015

Illustrated instructions

Instructions

Chloropyramine (Chloropyramine)