Chloropyramin - instructions for use, dose, side effects, contraindications

Competitively connects H₁-receptors of effector cells. Inhibits allergic reactions after the introduction of specific allergens, histamine, with cold urticaria.Reduces histamine-induced bronchoconstriction in bronchial asthma. Prevents allergic reactions, when they occur - facilitates the course of the disease. Reduces exudation and itching. Has a mild anticholinergic effect. Strengthens the effects of ethyl alcohol and other drugs that have a depressing effect on the central nervous system.

Pharmacokinetics:

After ingestion, up to 70% is absorbed in the gastrointestinal tract. The maximum concentration in the blood plasma is reached after 2 hours. The connection with plasma proteins is 93%.

The therapeutic effect develops 15-30 minutes after administration and lasts for 3-6 hours. Penetrates through the blood-brain and placental barrier, is found in breast milk. Metabolism in the liver.

The half-life is 14 hours. Elimination by the kidneys.

Indications:

It is used for the treatment of allergic rhinitis, hay fever, conjunctivitis, Quincke edema, urticaria. Used in the complex therapy of bronchial asthma.

ICD-10

VII.H10-H13.H10.1 Acute atopic conjunctivitis

XII.L20-L30.L20 Atopic dermatitis

X.J30-J39.J30.3 Other allergic rhinitis

X.J30-J39.J30.2 Other seasonal allergic rhinitis

X.J30-J39.J30.1 Allergic rhinitis caused by pollen of plants

XII.L20-L30.L20.8 Other atopic dermatitis

XII.L20-L30.L23 Allergic contact dermatitis

XII.L20-L30.L24 Simple irritant contact dermatitis

XII.L20-L30.L28.0 Simple chronic lichen

XII.L20-L30.L29 Itching

XII.L50-L54.L50 Hives

XIX.T66-T78.T78.3 Angioedema

XIX.T80-T88.T80.6 Other serum reactions

XIX.T80-T88.T88.7 Pathological reaction to medication or medicines, unspecified

Contraindications:

Severe renal failure, a period of newborns, an acute attack of bronchial asthma, an individual intolerance.

Carefully:

Chronic renal and hepatic insufficiency, cardiovascular diseases, closed-angle glaucoma, prostatic hyperplasia, urinary retention, advanced age, hypersensitivity.

Pregnancy and lactation:

Recommendations for FDA - Category C. It is used with caution during pregnancy and lactation in cases where the intended benefit exceeds the risk to the fetus and newborn.

Dosing and Administration:

Use in children

Inside, depending on age:

1-12 months: 1/4 tablets (6.5 mg) 2-3 times a day;

1-6 years: for ½ tablets (12.5 mg) 2 times a day;

6-14 years: 1/2 tablet (12.5 mg) 2-3 times a day.

Adults

To stop acute allergic reactions intravenously injected or intramuscularly 1-2 ml of a 2% solution.

Inside for 25 mg 2-3 times a day during meals. As needed the dose rises to 150 mg for 2-3 doses.

The highest daily dose: 4 mg for parenteral administration, 150 mg for oral administration.

The highest single dose: 4 mg for parenteral administration, 75 mg for oral administration.

Side effects:

Central and peripheral nervous system: dizziness, headache, rarely - depression, increased excitability, tremor, migraine, euphoria.

Hematopoietic system: rarely - agranulocytosis, leukopenia.

The cardiovascular system: rarely - arrhythmia, arterial hypotension, tachycardia.

Digestive system: dry mouth, dyspepsia, gastritis, edema of the tongue.

Musculoskeletal system: muscle weakness.

Sense organs: change in taste perception.

Urinary system: delay urination.

Dermatological reactions: photosensitization.

Allergic reactions.

Overdose:

Ataxia, anxiety, athetosis, convulsions, hallucinations.

Children: fever, anxiety, fixed mydriasis, reddening of the face, urinary retention, sinus tachycardia, coma.

Treatment is symptomatic.

Interaction:

Clinically significant interactions are not described.

Special instructions:

In the treatment it is not recommended to drive vehicles and work with moving mechanisms.

Instructions

Chloropyramine (Chloropyraminum)