Active substanceChloropyramineChloropyramine
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  • Dosage form: & nbspsolution for intravenous and intramuscular administration
    Composition:

    1 ml of the preparation contains:

    active substance: chloropyramine hydrochloride 20 mg; auxiliary substance: water for injection-up to 1 ml.

    Description:

    Transparent colorless or slightly colored liquid with a characteristic odor.

    Pharmacotherapeutic group:Antiallergic agent - H1-histamine receptor blocker
    ATX: & nbsp

    D.04.A.A.09   Chloropyramine

    R.06.A. C.03   Chloropyramine

    Pharmacodynamics:Chloropyramine is a blocker H1-gistaminovyh receptors. The chemical structure refers to the derivatives of ethylenediamine. Chloropyramine selectively blocks H1-gistaminovye receptors and reduces the permeability of capillaries. Prevents development and facilitates the course of allergic reactions. Has sedative, antihistaminic, m-holinoblokiruyuschee and pronounced antipruritic effect. Has moderate spasmolytic activity and antiemetic effect.
    Pharmacokinetics:

    Evenly distributed in the body, including the central nervous system (CNS). Penetrates through the blood-brain barrier. The association of chloropyramine with plasma proteins blood is 7.9%. The binding peak was noted at pH 6.8-7.4. Therapeutic concentration persists for 4-6 hours. Intensively metabolized in the liver. It is excreted mainly through the kidneys with urine in the form of metabolites. The excretion of chloropyramine in children can occur faster than in adults.

    Indications:

    Urticaria, angioedema (Quincke's edema), serum sickness, seasonal and year-round allergic rhinitis, conjunctivitis, contact dermatitis, skin itching, acute and chronic eczema,atopic dermatitis, food and drug allergies, allergic reactions to insect bites.

    Contraindications:

    Hypersensitivity to the components of the drug, acute attack of bronchial asthma, newborn children (full and premature), pregnancy, lactation.

    Carefully:

    Closed-angle glaucoma, urinary retention, prostatic hyperplasia, liver and / or kidney dysfunction, cardiovascular disease, elderly patients.

    Pregnancy and lactation:

    During pregnancy and during breastfeeding, the safety and efficacy of the drug are not established.

    Pregnancy and the period of breastfeeding are contraindications to the use of the drug.

    The use of the drug during pregnancy is possible only according to the doctor's prescription, if the intended benefit for the mother exceeds the potential risk to the fetus. If it is necessary to use the drug during lactation, the question of stopping breastfeeding should be resolved.

    Dosing and Administration:

    Intramuscularly or intravenously.

    Intravenously applied only in acute severe cases under the supervision of a doctor.

    Adults appoint 20-40 mg per day (the contents of 1-2 ampoules).

    Treatment in children begins with a dose of 5 mg (0.25 ml). In the future, the dose is increased depending on the age of the child.

    Children aged 1-12 months - 5 mg (0.25 ml).

    Children aged 1-6 years - 10 mg (0.5 ml).

    Children aged 7-18 years - 10-20 mg (0.5-1 ml).

    The daily dose should not exceed 2 mg / kg of body weight.

    In severe allergy, treatment should begin with an injection form of chloropyramine. Initially, it is administered intravenously slowly, then it is switched to intramuscular injection and in the final phase of treatment they switch to taking the tablets inside. The terms of treatment are set individually depending on the clinical symptoms and the patient's condition.

    Special patient groups

    Elderly, emaciated patients: the use of the drug requires extreme caution, as in these patients antihistamines often cause side effects (dizziness, drowsiness).

    Patients with impaired liver function: a dose reduction may be required due to a decrease in the metabolism of the active component of the drug in liver diseases. Patients with impaired renal function: it may be necessary to change the regimen of the drug and reduce the dose due to the fact that the active component is mainly released through the kidneys.

    The procedure for working with a polymer ampoule:

    1. Take an ampoule and shake it, holding it by the neck.

    2. Press the ampoule with your hand, while the drug should not be isolated, and rotate and separate the valve with rotating movements.

    3. Through the formed hole, immediately connect the syringe with the ampoule.

    4. Turn the ampoule over and slowly put the contents into the syringe.

    5. Put the needle on the syringe.

    Side effects:

    From the central nervous system: lethargy, weakness, drowsiness, dizziness, nervous excitement, headache, euphoria, a feeling of fatigue, irritability, tremor, convulsions, impaired coordination of movements, impaired vision, encephalopathy; children may have some stimulating effect on the central nervous system, manifested by anxiety, increased irritability, insomnia.

    On the part of the digestive system: dry mouth, nausea, vomiting, gastralgia, diarrhea / constipation, loss or increase in appetite, discomfort in the abdomen, pain in the upper abdomen.

    From the side of the urinary system: difficulty urinating, urinary retention.

    From the cardiovascular system: decrease in blood pressure (more often in elderly patients), tachycardia, arrhythmia.

    On the part of the hematopoiesis system: hemolytic anemia, other pathological changes in the cellular composition of the blood, very rarely - leukopenia, agranulocytosis.

    On the part of the organs of vision: increased intraocular pressure, attacks of glaucoma.

    Other: photosensitivity, muscle weakness, myopathy, ataxia, allergic reactions.

    Overdose:

    Symptoms: hallucinations, anxiety, ataxia, movement coordination disorders, athetosis, convulsions. In young children, excitement, anxiety, dry mouth, fixed dilated pupils, redness of the face, sinus tachycardia, urinary retention, fever, coma. In adults, fever and redness of the face are not constant, after a period of excitement followed by convulsions and post-convulsive depression, coma.

    Treatment: symptomatic therapy. It is necessary to control the parameters of blood pressure and respiration. The specific antidote is not known.

    Interaction:

    Strengthens the effect of drugs for general anesthesia, hypnotics, sedatives, tranquilizers, barbiturates, anxiolytics,atropine, parasympatholytics (M-holinoblokatorov), opioid analgesics, local anesthetics.

    Tricyclic antidepressants and monoamine oxidase inhibitors enhance m-anticholinergic and inhibitory effect on the CNS.

    Caffeine and phenamine reduce the depressant effect on the central nervous system.

    Simultaneous use with ethanol is not recommended (risk of severe CNS depression). When combined with ototoxic drugs chloropyramamine can mask the early manifestations of ototoxicity.

    Special instructions:

    During treatment, it is unacceptable to drink alcoholic beverages. Taking the drug at night can increase the symptoms of reflux esophagitis. If during long-term use of the drug is observed wanton fever, laryngitis, pallor, jaundice, ulceration of the oral mucosa. bruising, unusual bleeding and trudnoostanavlivaemye, seek medical attention because, in rare cases, prolonged use of antihistamines may cause undesired hematopoietic (leukopenia, agranulocytosis, thrombocytopenia, hemolytic anemia).Antihistamines can distort the reaction when setting skin allergological tests, therefore, a few days before the planned test, the drug should be discontinued.

    Effect on the ability to drive transp. cf. and fur:

    During the treatment period it is necessary to refrain from driving motor vehicles and practicing potentially dangerous activities that require an increased concentration of attention and speed of psychomotor reactions.

    Form release / dosage:

    A solution for intravenous and intramuscular administration of 20 mg / ml.

    Packaging:

    1 ml in ampoules of low-density polyethylene or polypropylene.

    For 5 or 10 ampoules together with instructions for use in a pack of cardboard.

    Storage conditions:

    Store at a temperature not exceeding 25 ° C.

    Keep out of the reach of children.

    Shelf life:

    4 years.

    Do not use after the expiration date!

    Terms of leave from pharmacies:On prescription
    Registration number:LP-003877
    Date of registration:03.10.2016
    Expiration Date:03.10.2021
    The owner of the registration certificate:GROTEKS, LLC GROTEKS, LLC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp18.10.2016
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