Clarinedin - instructions for use, dose, side effects, contraindications

H1-histamine receptor blocker (long-acting). Suppresses the release of histamine and leukotriene C4 from mast cells. Prevents development and facilitates the course of allergic reactions. It has anti-allergic, antipruritic and antiexcudative action. Reduces the permeability of capillaries, prevents the development of edema of tissues, relieves spasms of smooth muscles. The antiallergic effect develops in 30 minutes, reaches a maximum in 8-12 hours and lasts for 24 hours. It does not affect the central nervous system and does not cause addiction (because it does not penetrate the blood-brain barrier).

Pharmacokinetics:

After oral administration, it is quickly and completely absorbed in the gastrointestinal tract. The time to reach the maximum concentration is 1.3-2.5 h; the intake of food slows it down for one hour. The connection with plasma proteins is 97%.

Metabolized in the liver with the formation of an active metabolite of descarbon ethoxyloratadine with the participation of cytochrome isoenzymes CYP3A4 and to a lesser extent CYP2D6. To be excreted through the kidneys and intestines. The half-life of loratadine is 8-11 hours. A longer half-life is noted in the elderly, as well as in patients with chronic liver diseases.

Indications:

Allergic rhinitis (seasonal and year-round), conjunctivitis, hay fever, urticaria (including chronic idiopathic), Quincke's edema, allergic itching dermatoses, pseudoallergic reactions caused by the release of histamine, allergic reactions to insect bites.

Contraindications:

Hypersensitivity to the components of the drug, pregnancy, lactation, children under 2 years.

Carefully:Liver failure.

Dosing and Administration:

Inside, with food, with a little water.

1 measuring spoon or 1 measuring cup contains 5 ml of syrup.

Adults and children over 12 years of age - 10 mg (10 ml) once a day. With hepatic failure, the initial dose is 5 mg (5 ml) per day.

Children from 2 to 12 years with a body weight of less than 30 kg - 5 mg (5 ml) 1 time per day. Children with a body weight of more than 30 kg - 10 mg (10 ml) 1 time per day.

Side effects:

The adverse events listed below with loratadine occurred at a frequency of> 2% and approximately at the same frequency as with placebo ("dummies"),

In adults: headache, fatigue, dry mouth, drowsiness, gastrointestinal disorders (nausea, gastritis), as well as allergic reactions in the form of rashes. In addition, there were rare reports of anaphylaxis, alopecia, impaired liver function, palpitation, tachycardia.

Have a detectiveth rarely: headache, nervousness, sedation.

Overdose:

Symptoms: drowsiness, tachycardia, headache. In case of overdose, see a doctor.

Treatment: induction of vomiting, gastric lavage, intake of sorbents (activated carbon).

Interaction:

Ethanol reduces the effectiveness of loratadine.

Erythromycin, cimetidine, ketoconazole, when combined with loratadine increase the concentration of loratadine in blood plasma, without causing clinical manifestations and without affecting the ECG.

Inductors of microsomal oxidation (phenytoin, barbiturates, flumecinol, rifampicin, phenylbutazone, tricyclic antidepressants) reduce the effectiveness of loratadine.

Effect on the ability to drive transp. cf. and fur:

During the treatment period, it is necessary to refrain from engaging in potentially dangerous activities that require a high concentration of attention and speed of psychomotor reactions.

Form release / dosage:

Syrup 5 mg / 5 ml.

Packaging:

Syrup for oral intake of 50 ml or 100 ml in bottles of dark color from polyethylene terephthalate or glass. Each bottle is placed along with the instructions for use, a measuring spoon for 5 ml or a measuring cup of 5 ml into individual cardboard packs.

Storage conditions:

Store in a dark place at a temperature of no higher than 25 °

Keep out of the reach of children.

Shelf life:

3 years. Do not use after the expiration date printed on the package.

Terms of leave from pharmacies:Without recipe

Registration number:LSR-007946/08

Date of registration:08.10.2008 / 21.01.2016

The owner of the registration certificate:ROSLEKS PHARM, LLCROSLEKS PHARM, LLC Russia

Manufacturer: & nbsp

ROSLEKS PHARM, LLC Russia

Information update date: & nbsp22.06.2016

Illustrated instructions

Instructions

Clarinedine (Clarnedene)