Loratadin-OBL - instructions for use, dose, side effects, contraindications

Excipients: lactose (sugar milk), potato starch, silicon dioxide colloid (aerosil), povidone (polyvinylpyrrolidone low molecular weight), magnesium stearate.

Description:Tablets are white or almost white, flat-cylindrical with a bevel.

Pharmacotherapeutic group:Antiallergic agent H1-histamine receptor blocker

ATX: & nbsp

R.06.A.X Other antihistamines for systemic use

R.06.A.X.13 Loratadin

Pharmacodynamics:

Loratadn - a blocker of H1-gnethamyl receptors (long-acting). Inhibits the release of histamine and leukotriene C4 from mast cells. Prevents development and facilitates the course of allergic reactions. It has anti-allergic, antipruritic, proto-exsudative action. Reduces the permeability of capillaries, prevents the development of edema of tissues, relieves spasms of smooth muscles.

The antiallergic effect develops in 30 minutes, reaches a maximum in 8-12 hours and lasts for 24 hours. It does not affect the central nervous system and does not cause addiction (because it does not penetrate the blood-brain barrier).

Pharmacokinetics:

Quickly and completely absorbed in the gastrointestinal tract. Time to reach the maximum concentration - 1,3-2,5 h; the intake of food slows it down for 1 hour. The maximum concentration in elderly people increases by 50% with alcoholic liver damage - with increasing severity of the disease. The connection with plasma proteins is 97%.Metabolnznetsya in the liver with the formation of an active metabolite descorobetoxyloratadna with the participation of isoenzymes cytochrome P 450 CYP3A4 and to a lesser extent CYP2D6.

The equilibrium termination of loratadine and metabolite in plasma is reached on the 5th day of administration.

Does not penetrate the blood-brain barrier.

The half-life period is loratadn - 3-20 h (average 8.4), active metabolite - 8.8-92 h (average 28 h); in elderly patients, respectively - 6,7-37 hours (an average of 18.2 hours) and 11-38 hours (17.5 hours). In alcoholic liver damage, the half-life increases with increasing severity of the disease. It is excreted by the kidneys and through the intestines. In patients with chronic renal failure and during hemodialysis, the pharmacokinetics practically does not change.

Indications:Seasonal and all-the-year-round allergic rhinitis, conjunctivitis, nollnosis, urticaria (including chronic idiopathic), Quincke's edema, allergic itching dermatoses; pseudoallergic reactions, allergic reactions to insect bites, itching of various etiologies.

Contraindications:Hypersensitivity. Pregnancy, lactation. Liver failure. Children weighing less than 30 kg.Due to the presence of lactose, patients with rare hereditary diseases, such as galactose intolerance, lactase deficiency or glucose-galactose malabsorption, should not take the drug.

Dosing and Administration:Inside. Adults and children with a body weight of more than 30 kg - 10 mg (1 tablet) of the drug 1 time per day. The daily dose is 10 mg.

Side effects:

From the nervous system: anxiety, agitation (in children), asthenia, drowsiness, hyperkinesia, paresthesia, tremor, amnesia, depression, fatigue.

From the skin and subcutaneous fat: dermatitis.

From the genitourinary system: a change in the color of urine, painful urge to urinate: dysmenorrhea, menorrhagia, vaginitis.

From the side of metabolism: weight gain, sweating, thirst.

From the side of the musculoskeletal system: spasms of gastrocnemius muscles, arthralgia, myalgia.

From the digestive system: dry mouth, taste change, anorexia, constipation or diarrhea, dyspepsia, gastritis, flatulence, increased appetite, stomatitis, nausea, vomiting.

From the respiratory system: cough, bronchospasm, dry nasal mucosa, sinusitis.

From the sense organs: visual impairment, conjunctivitis, pain in the eyes and ears.

From the side of the cardiovascular system: decrease or increase in blood pressure, palpitations.

Other: blepharospasm, dysphonia.

Photosensitivity, back pain, chest pain, fever, chills, pain in the mammary glands.

Overdose:

Symptoms: drowsiness, tachycardia, headache. In case of overdose, see a doctor.

Treatment: induction of vomiting, gastric lavage, reception of activated charcoal.

Interaction:Ethanol reduces the effectiveness of loratadine. Erythromycin, cimetidine, ketoconazole when combined with loratadine increase the concentration of loratadine in blood plasma, without causing clinical manifestations and without affecting the ECG. Inductors of microsomal oxidation (phenytoin, ethanol, barbiturates, flumecinol, rifampicin, phenylbutazone, tricyclic antidepressants) reduce the effectiveness of loratadine.

Effect on the ability to drive transp. cf. and fur:During the treatment period, it is necessary to refrain from engaging in potentially dangerous activities that require a high concentration of attention and speed of psychomotor reactions.

Form release / dosage:Tablets 10 mg.

Packaging:

By 7, 10, 15, 20 or 30 tablets in a contour mesh box made of polyvinylchloride film and aluminum foil printed lacquered.

For 1, 2 or 3 contour squares, together with the instructions for use in a pack of cardboard.

Storage conditions:In a dry, dark place at a temperature of no higher than 25 FROM. Keep out of the reach of children.

Shelf life:3 years. Do not use after the date shown on the package.

Terms of leave from pharmacies:Without recipe

Registration number:P N002868 / 01

Date of registration:10.09.2008 / 18.05.2012

Expiration Date:Unlimited

The owner of the registration certificate:OBOLENSKOE PHARMACEUTICAL ENTERPRISE, CJSC OBOLENSKOE PHARMACEUTICAL ENTERPRISE, CJSC Russia

Manufacturer: & nbsp

OBOLENSKOE PHARMACEUTICAL ENTERPRISE, CJSC Russia

Information update date: & nbsp19.03.2018

Illustrated instructions

Instructions

Loratadin-OBL (Loratadine-OBL)