Caffeine + Paracetamol + Phenylephrine + Chlorphenamine (Coffeinum + Paracetamolum + Phenylephrinum + Pheniraminum + [Acidum ascorbinicum])

Pharmacodynamics Pharmacokinetics Indications Carefully Contraindications Dosing and Administration Side effects
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Clinical and pharmacological group: & nbsp

Alpha-adrenomimetics

Anilides

H1-antihistamines

NSAIDs - Salicylic acid derivatives

Included in the formulation
  • Ajikold®
    pills inwards 
    Agio Pharmaceuticals Ltd.     India
  • Rankof®
    pills inwards 
    SAVAFARM, LLC     Russia
  • Rince®
    pills inwards 
    Johnson & Johnson, LLC     Russia
  • Rinicold
    pills inwards 
    Shraya Life Senses Pvt. Ltd.     India
    • АТХ:

    N.02.B.E.51   Paracetamol in combination with other drugs, excluding psycholeptics

    Pharmacodynamics:

    Combined drug.

    Paracetamol - the main component of the drug. Has a pronounced antipyretic and analgesic effect. Relieves headache with rhinitis, sinusitis, eliminates pain in muscles, reduces pain in the throat with colds, SARS.

    Phenylephrine has a pronounced vasoconstrictive effect, as a result of which the nasal congestion and the amount of discharge from it decreases.

    Chlorfeniramine - antiallergic component of the drug. Has a pronounced anti-edematous effect, reduces permeability of the vascular wall, flushing of the nasal mucosa, thereby facilitating breathing.

    Caffeine has a stimulating effect on the central nervous system, eliminates asthenic syndrome, reduces drowsiness, increases physical and mental performance.

    Pharmacokinetics:Not presented.
    Indications:Treatment of febrile syndrome in ARI, ARVI, accompanied by chills, headache, sore throat, muscles, rhinorrhea.
    ICD-10

    X.J00-J06.J01   Acute Sinusitis

    X.J00-J06.J06   Acute upper respiratory tract infections of multiple and unspecified sites

    X.J30-J39.J30   Vasomotor and allergic rhinitis

    XVIII.R50-R69.R50   Fever of unknown origin

    XVIII.R50-R69.R51   Headache

    XVIII.R50-R69.R60.0   Localized edema

    X.J00-J06.J00   Acute nasopharyngitis (runny nose)

    XIII.M70-M79.M79.1   Myalgia

    XVIII.R50-R69.R50.0   Fever with chills

    Contraindications:
    • Hypersensitivity to the drug components
    • Simultaneous reception of tricyclic antidepressants, beta-blockers, MAO inhibitors, including in the period of 14 days after their cancellation
    • Children's age (up to 6 years - for tablets, up to 15 years - for sachets)
    • Pregnancy
    • Lactation
    Carefully:

    Elderly patients with chronic renal or hepatic insufficiency should take the drug intake.

    The drug is used with caution in patients suffering from atherosclerosis, hypertension, hyperthyroidism, diabetes mellitus, bronchial asthma, chronic obstructive pulmonary disease, narrow-angle glaucoma, Gilbert's syndrome, Dubin-Johnson syndrome, Rotor.

    Cautiously appoint at pheochromocytoma, deficiency of glucose-6-phosphate dehydrogenase, prostatic hyperplasia.

    Pregnancy and lactation:Contraindicated in pregnancy and breastfeeding.
    Dosing and Administration:

    Take the drug should be with plenty of fluids 2 hours after eating.

    A bag with different flavors (lemon, orange, pineapple) is dissolved in 200 ml of hot water, mixed. Adults and children over 15 years take 1 packet 3-4 times a day with an interval between doses 4-6 hours. The maximum daily dose is 4 sachets.

    The drug in tablets take 1-2 tablets 3-4 times a day. The maximum daily dose is 8 tablets.

    Children over 6 years of age are prescribed 1 tablet every 4-6 hours, but no more than 4 times a day for no more than 5 days.

    The course of treatment should not exceed 5 days.

    Side effects:Allergic reactions, headache, dizziness, tachycardia, arterial hypertension, nausea, dry mouth, epigastric pain, increased excitability, visual disturbances, sleep disturbances are possible.
    Overdose:

    Overdose is usually associated with taking large doses of paracetamol (10-15 g).Symptoms: pallor of the skin, nausea, vomiting, toxic hepatitis right up to hepatonecrosis. In the blood there is an increase in "liver" transaminases and an increase in prothrombin time.

    Treatment: gastric lavage, reception of activated charcoal, symptomatic therapy.

    Interaction:

    Paracetamol decreases the effectiveness of diuretics.

    The simultaneous use of chlorpheniramine with MAO inhibitors, furazolidone can lead to nervous excitation, increased body temperature, a sharp increase in blood pressure right up to the hypertensive crisis.

    The drug enhances the effects of ethanol, sedatives.

    Application simultaneously with halothane increases the risk of ventricular arrhythmia.

    Phenylephrine when used with guanethidine reduces its hypotensive effect.

    Hepatotoxic effect of paracetamol increases with simultaneous use with barbiturates, rifampicin, diphenin, carbamazepine and other inducers of microsomal liver enzymes.

    The risk of developing glaucoma increases with the use of the drug simultaneously with glucocorticosteroids.

    Tricyclic antidepressants enhance the adrenomimetic effect of phenylephrine, guanethidine is the alpha-adrenostimulating effect of phenylephrine.

    Special instructions:

    During the treatment with the drug you should not drink alcohol, since it is possible to toxic liver damage.

    It is impossible to carry out treatment with the drug simultaneously with tranquilizers and hypnotics.

    Do not take the drug with other drugs containing paracetamol to avoid an overdose.

    During treatment with the drug, patients should be careful when driving vehicles and performing potentially dangerous jobs that require quick reaction and concentration.

    Instructions
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