Cofetamine (Coffetamin)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
Read on
Active substanceCaffeine + ErgotamineCaffeine + Ergotamine
Similar drugsTo uncover
  • Cofetamine
    pills inwards 
    TATHIMFARMPREPARATY, JSC     Russia
    • Dosage form: & nbspcoated tablets
    Composition:

    Active substances: caffeine - 100 mg and ergotamine tartrate - 1 mg;

    auxiliary substances: potato starch, talc, stearic acid, sucrose, dextrose.

    Description:The tablets covered with a cover, white color, biconcave form. On the cross-section, two layers are visible: a white shell, a white or white core with a creamy shade of color
    Pharmacotherapeutic group:Anti-migraine means
    ATX: & nbsp

    N.02.C.A.52   Ergotamine in combination with other drugs, excluding psycholeptics

    Pharmacodynamics:

    Combined drug. Caffeine stimulates the central nervous system, mainly the cortex of the brain, respiratory and vasomotor centers. Increases mental and physical performance, reduces drowsiness, a sense of fatigue. Has a pronounced cardiotonic action: increases the strength and heart rate, increases blood pressure with hypotension. Ergotamine causes vasoconstrictor action. Caffeine accelerates the absorption of ergotamine.

    Pharmacokinetics:

    After oral administration about 62 % ergotamine is absorbed in the gastrointestinal tract.The maximum concentration in the plasma is achieved after 2 hours after ingestion. Binding to plasma proteins - 98%. Ergotamine is metabolized in the liver with the formation of pharmacologically active metabolites. The ergotamine is excreted predominantly with bile as in unchanged form, and in the form of metabolites. Excretion is biphasic, half-lives of 2.7 hours and 21 hours for the I and II phases, respectively.

    After taking the drug inside caffeine absorbed quickly and almost completely. Binding to plasma proteins is 35%. Caffeine almost completely metabolized in the body. Metabolites are excreted mainly in the urine. The half-life is about 3.5 hours.

    Indications:

    Migraine, headache in the background of arterial hypotension.

    Contraindications:

    Individual intolerance of the components of the drug, pregnancy, lactation.

    Carefully:With caution - sleep disorders, anxiety disorders, organic diseases of the cardiovascular system (including acute myocardial infarction, angina pectoris, severe atherosclerosis, paroxysmal tachycardia, frequent ventricular extrasystole, arterial hypertension,obliterating diseases of peripheral vessels), hepatic and / or renal failure, glaucoma, advanced age.
    Pregnancy and lactation:contraindicated
    Dosing and Administration:

    Inside, 1-2 tablets during an attack of a headache, then 1 tablet 2-3 times a day for several days. The maximum single dose - 2 tablets, daily - 4 tablets.

    It is not recommended to use for a long time (in order to avoid the phenomenon of ergotism): after 7 days of use in cases requiring longer treatment, take a break (3-4 days).

    Side effects:

    From the nervous system: agitation, anxiety, tremor, anxiety, headache, dizziness, convulsions, paresthesia in the limbs, increased tendon reflexes, tachypnea, insomnia; with sudden withdrawal - increased inhibition of the central nervous system, increased fatigue, drowsiness.

    From the side of the cardiovascular system: tachycardia, cardialgia, increased blood pressure.

    From the digestive system: nausea, vomiting, diarrhea.

    Allergic reactions: swelling, itchy skin.

    Other: with prolonged use - addiction, drug dependence,weakness in the legs, myalgia, Lerish's syndrome (severe cyanosis, lack of pulse on the lower limbs, pain, impaired sensitivity to the distal type).

    Overdose:

    Symptoms: increased severity of side effects, including nausea, vomiting, numbness of fingers and toes, blocking, drowsiness, epileptic seizures, stupor, coma. Treatment: gastric lavage, reception of activated charcoal, if necessary - symptomatic therapy.

    Interaction:

    Enhances the pharmacological action of drugs containing ergot alkaloids and caffeine.

    Caffeine is an adenosine antagonist (large doses of adenosine may be required). With the joint use of caffeine and barbiturates, primidone, anticonvulsants (hydantoin derivatives, especially phenytoin) it is possible to increase metabolism and increase caffeine clearance; cimetidine, oral contraceptives, disulfiram, ciprofloxacin, norfloxacin - a decrease in the metabolism of caffeine in the liver (slowing its release and increasing blood concentrations).

    Means that stimulate the central nervous system - may be excessive stimulation of the central nervous systemsystem.

    Mexiletine - reduces caffeine release up to 50%; nicotine - Increases the speed of caffeine removal.

    MAO inhibitors, furazolidone, procarbazine and selegiline - large doses of caffeine can cause the development of dangerous cardiac arrhythmias or a marked increase in blood pressure.

    Caffeine reduces the absorption of calcium in the gastrointestinal tract.

    Reduces the effect of narcotic and hypnotics; increases - non-narcotic analgesics (increased absorption). Increases the excretion of lithium drugs with urine.

    Accelerates absorption and enhances the action of cardiac glycosides, increases their toxicity.

    Joint use of caffeine with beta-blockers can lead to mutual suppression of therapeutic effects: with adrenergic bronchodilators - additional stimulation of the central nervous system and other additive toxic effects.

    Caffeine can reduce the clearance of theophylline and, possibly, other xanthines, increasing the possibility of additive pharmacodynamic and toxic effects. The vasoconstrictor effect of the drug is enhanced by alpha-adrenostimulants, beta-adrenoblockers, serotonin agonists (including sumatriptan) and nicotine. Macrolides increase the toxicity of ergotamine (decreased hepatic clearance of caffeine).
    Special instructions:not described
    Effect on the ability to drive transp. cf. and fur:not described
    Form release / dosage:

    Tablets, coated with a shell, 10 pieces in a glass tube or 10 pieces in a planar cell package. A test tube or 1-2 contour packs together with the instructions for use are placed in a bundle.

    Shelf life

    2 years. Do not use after the expiration date printed on the package.

    Storage conditions

    List B. In a dry, dark place, at a temperature of no higher than 25 0 FROM.

    Keep out of the reach of children.

    Storage conditions:

    List B. In a dry, dark place, at a temperature of no higher than 250 FROM.

    Shelf life:

    2 years. Do not use after the expiration date printed on the package.

    Terms of leave from pharmacies:On prescription
    Registration number:LS-000269
    Date of registration:15.03.2010 / 26.08.2011
    Expiration Date:Unlimited
    The owner of the registration certificate:TATHIMFARMPREPARATY, JSC TATHIMFARMPREPARATY, JSC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp26.08.2011
    Illustrated instructions
      Instructions
      Up