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Dosage form: & nbsplyophilizate for oral solution preparation
Composition:

The preparation is a microbial mass of live Escherichia coli strains of M-17 strain lyophilized in a culture medium with the addition of a drying medium, sucrose.

A single dose of the drug is contained;

Active substance: live E. coli - at least 10x109

Protective environment for drying: sucrose - 9%.

Description:

The preparation has the appearance of a crystalline or porous mass of various shades of beige or whitish-gray color with a specific odor.

Pharmacotherapeutic group:Eubiotic
ATX: & nbsp

A.07.F.A   Antidiarrhoeal preparations of biological origin regulating the balance of intestinal microflora

Pharmacodynamics:
The therapeutic effect is due to antagonistic activity of Escherichia coli against pathogenic and opportunistic microorganisms, especially against Shigella, Salmonella, Proteus.
Indications:

Treatment of chronic colitis, conditions after acute intestinal infections, intestinal dysfunction resulting from dysbacteriosis of various etiologies in adults and children from 6 months of age.

The preparation is used:

- with prolonged and chronic dysentery;

-colitis and enterocolitis of different etiology;

- Dysbacteriosis of different etiology;

-allergic and alimentary gastroenteritis and colitis;

- Crohn's disease;

- acute vascular diseases of the intestine;

-prozoic intestinal diseases, shigellosis, other intestinal infections;

-diarrhea and gastroenteritis of supposedly infectious origin;

- food poisoning;

-in complex treatment for chronic diseases of the gastrointestinal tract (nonspecific and specific chronic colitis and enterocolitis with severe dysbiotic impairment), in cases of necessity, a pronounced stimulating effect on the body;

- healing of convalescents;

after acute intestinal infections.

Contraindications:

Child age from birth to 6 months.

Specific and nonspecific ulcerative colitis.

Pregnancy and lactation:Use of the drug during pregnancy and during breastfeeding should additionally be agreed with the attending physician.
Dosing and Administration:

The contents of the vial to dissolve boiled water at room temperature at the rate of 5 ml (teaspoon) of water per 1 dose of the drug.

Dissolve as follows: pour the required amount of water in a glass (according to the number of doses indicated on the vial); open the bottle, removing the metal cap and rubber stopper; from the glass to transfer a small amount of water into the bottle; after dissolution (the preparation dissolves no more than 5 minutes with the formation of an opaque homogeneous suspension), the contents of the vial should be transferred to the same beaker and mixed. One teaspoon of the drug dissolved in this way is 1 dose. Dissolved drug is not subject to storage.

The drug should be taken at least 20-30 minutes before meals and 1-2 hours after meals. Breast children can be given the drug immediately before feeding.

The drug is taken orally in the following daily doses:

- children from 6 months to 1 year - 2-4 doses;

- children from 1 year to 3 years - 4-8 doses;

- Children older than 3 years and adults - 6-12 doses.

Daily doses can be divided into 2-3 doses.

The number of doses and duration of treatment is determined by the doctor depending on the severity, duration of the disease and the severity of dysbiosis.

If necessary, treatment courses can be repeated, but not earlier than 3-6 months with a preliminary study of the microflora of the gastrointestinal tract. In between the appointments of colibacterin, patients are shown bifido or lactose-containing drugs.

Features of the drug during the first admission or withdrawal. Not found.

If a person misses one or more doses, the last dose should be re-accepted and continue treatment according to the indicated schedule.

Side effects:

The use of colibacterin usually does not cause adverse reactions. In rare cases, the process of treatment may lead to the appearance of mild diarrheal disorders, which usually pass on their own and do not require the withdrawal of the drug or the appointment of treatment. In the case of a more pronounced reaction, temporary discontinuation of the drug or discontinuation of colibacterin treatment is appropriate. If any of the side effects listed in the manual are aggravated, or if you notice any other side effects not listed in the instructions, tell your doctor.

Overdose:
There were no symptoms of an overdose with colibacterin.
Interaction:

It is not recommended simultaneous chemotherapy and antibiotic treatment.

Special instructions:
Do not use the product whose packaging integrity is broken (cracked bottles), if there is no marking, if the physical properties change (color change, shrinkage of biomass, presence of foreign inclusions), improper storage, expired.
Effect on the ability to drive transp. cf. and fur:The drug does not affect the ability to drive vehicles.
Form release / dosage:Liofilizate for solution for oral administration, not less than 10x109 Cfu / dose.
Packaging:

5 doses per vial.

For 5 bottles in a contoured cell packaging made of polyvinylchloride film, sealed with aluminum foil or without it. In a pack of cardboard, two contour squares or 10 bottles with a separating snake, instructions for use.

Storage conditions:

Store in a dry, dark place at a temperature of no higher than 10 ° C.

Shelf life:

1 year. Do not use after the expiration date.

Terms of leave from pharmacies:Without recipe
Registration number:P N002820 / 01-2003
Date of registration:18.09.2008 / 20.03.2012
Expiration Date:Unlimited
The owner of the registration certificate:BIOMED them. I.I.Mechnikova, OJSC BIOMED them. I.I.Mechnikova, OJSC Russia
Manufacturer: & nbsp
Information update date: & nbsp31.01.2018
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