Combined drug with pronounced antihypoxic, nootropic and vasodilating effect.
Both components mutually potentiate their own antihypoxic effect and have a vasodilating effect. Combined drug also contributes to a significant increase in blood flow in the brain. The toxicity of the combination does not exceed the toxicity of the individual constituents of the preparation.
Pyracetam is a nootropic agent. Has a positive effect on brain metabolic processes: increases the concentration of ATP in the brain tissue, enhances the synthesis of RNA and phospholipids, stimulates glycolytic processes, increases the utilization of glucose. It improves the integrative activity of the brain, facilitates the consolidation of memory, facilitates the learning process.
Changes the speed of propagation of excitation in the brain, improves microcirculation, without providing a vasodilating action, suppresses the aggregation of activated platelets. Has a protective effect on brain damage caused by hypoxia, intoxication, electric shock; enhances the alpha and beta activity, reduces delta activity on the EEG, reduces the severity of the vestibular nystagmus.
Improves interneuronal transmission and synaptic conductivity in neocortical structures, increases mental performance, improves cerebral blood flow. The effect develops gradually.
Practically does not have sedative and psycho-stimulating effect.
Cinnarizine is a selective blocker of slow calcium channels,reduces the entry of Ca2 + into cells and reduces its content in the depot of the plasmolemma, lowers the tone of the smooth muscles of arterioles, reduces their response to biogenic vasoconstrictors £epinephrine, norepinephrine, dopamine, angiotensin, vasopressin, serotonin).
Has a vasodilating effect (especially with respect to cerebral vessels, enhancing the antihypoxic effect of piracetam), without having a significant effect on blood pressure. It shows moderate antihistamine activity, reduces the excitability of the vestibular apparatus, lowers the tone of the sympathetic nervous system. In patients with peripheral circulatory disorders improves blood supply to organs and tissues (including myocardium), strengthens postischemic vasodilation. Increases the elasticity of erythrocyte membranes, their ability to deform, reduces the viscosity of the blood.