Corvalol (Corvalol)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Dosage form: & nbsppills
Composition:

For one tablet:

Active substances:

Ethyl bromoisovalerate-8.2 mg

(ethyl alpha-bromoisovaleric acid ethyl ester)

Phenobarbital 7.5 mg

Mint pepper leaves oil - 0.58 mg

Excipients:

β-cyclodextrin 55.55 mg

Potato starch - 13,00 mg

Lactose Monohydrate - 43.77 mg

Cellulose microcrystalline - 10.50 mg

Magnesium stearate 0.90 mg

Description:Tablets of white or almost white color with impregnations, round shape with a flat surface, beveled to the edge with chamfers.
Pharmacotherapeutic group:Sedative remedy
ATX: & nbsp
  • Other sleeping pills and sedatives
    • Pharmacodynamics:

    Combined drug, has a sedative and spasmolytic effect, facilitates the onset of natural sleep.

    Ethyl bromizovaleralianate (ethyl ester of alpha-bromizovaleric acid) has a sedative (similar to the valerian effect) and spasmolytic effect due to irritation, mainly of the oral and nasopharyngeal receptors, a decrease in reflex excitability in the central parts of the nervous system and increased inhibition in neurons of the cortex and subcortical structures of the brain, a also a decrease in the activity of the central vasomotor centers and a direct local antispasmodic effect on smooth muscle.

    Phenobarbital possesses sedative (in small doses), hypnotic, miorelaxing and antispasmodic action, it helps to reduce excitation of the central nervous system (CNS) and facilitates the onset of sleep, enhances the sedative effect of other components.

    Peppermint leaves are reflexively vasodilating. spasmolytic, mild choleretic, antiseptic. The mechanism of action is associated with the ability to irritate the "cold" receptors of the oral mucosa and reflexively expand primarily the vessels of the heart and brain. Eliminates the phenomena of flatulence due to irritation of the receptors of the mucous membrane of the gastrointestinal tract (GIT), strengthening the peristalsis of the intestine.
    Pharmacokinetics:Data on the pharmacokinetics of ethyl bromoisovalericanate and components of peppermint are absent. Ingestion phenobarbital absorbed slowly, completely. The maximum concentration in blood plasma is determined after 1-2 hours, the connection with plasma proteins is 50%, in newborns - 30-40%. Metabolized in the liver, induces microsomal liver enzymes by isoenzymes CYP3A4, CYP3A5, CYP3A7 (the rate of enzymatic reactions increases 10-12 times). Cumulated in the body. The half-life is 2-4 days. It is excreted by the kidneys in the form of glucuronide. about 25% in the unchanged
    Indications:

    Corvalol is prescribed as a symptomatic (calming and vasodilating) remedy for functional disorders of the cardiovascular system, with neurosis-like conditions, accompanied by increased irritability, disturbed sleep, tachycardia, a state of excitation with pronounced vegetative manifestations; as an antispasmodic agent for spasms of the intestine.

    Contraindications:

    - Hypersensitivity to the components of the drug;

    - severe impairment of kidney and / or liver function;

    - pregnancy;

    - the period of breastfeeding;

    - children under 18 years of age (efficacy and safety not established);

    - deficiency of lactase, lactose intolerance, glucose-galactose malabsorption (the preparation contains lactose).

    Carefully:

    Impaired renal and / or liver function.

    If you have any of the listed diseases / conditions, always consult a doctor before taking the drug.

    Pregnancy and lactation:

    The use of the drug Corvalol during pregnancy and during breastfeeding is contraindicated, since the drug contains phenobarbital, which penetrates the placenta and has a teratogenic effect, has a negative effect on the formation and further functioning of the central nervous system of the fetus and newborn; penetrates into breast milk, it is possible the development of physical dependence in the newborn. If you need to use the drug during breastfeeding, you should decide whether to stop breastfeeding with breast milk.

    Dosing and Administration:

    For oral administration, before drinking, take with water.

    Adults, as a rule, appoint 1-2 tablets of the drug 2 times a day.

    With tachycardia, it is possible to increase the single dose to 3 tablets.

    The maximum daily dose is 6 tablets.

    Dosage and duration of treatment is set by the doctor individually for each patient.

    Side effects:

    Corvalol, as a rule, well tolerated. In some cases, there may be drowsiness, mild dizziness, slow heart rate, decreased ability to concentrate, an allergic reaction.There may be disturbances from the gastrointestinal tract. These phenomena occur with a decrease in the dose of the drug or discontinuation of the drug.

    With long-term use of the drug, it is possible to form drug dependence, addiction, the "withdrawal" syndrome, as well as the accumulation of bromine in the body and the development of bromine phenomena (depressive mood, apathy, rhinitis, conjunctivitis, haemorrhagic diathesis, impaired coordination of movements).

    If any of the side effects listed in the manual are aggravated, or if you notice any other side effects not listed in the instructions, tell your doctor.

    Overdose:

    Symptoms: depression of the central nervous system, nystagmus, ataxia, lowering blood pressure, agitation, dizziness, weakness, chronic intoxication with bromine (depression, apathy, rhinitis, conjunctivitis, hemorrhagic diathesis, impaired coordination of movements).

    Treatment: discontinuation of the drug, gastric lavage and symptomatic therapy, with CNS depression - caffeine, nikethamide.

    Interaction:

    Drugs that depress the central nervous system, enhance the effect of the drug.

    Phenobarbital (inductor of microsomal oxidation) can reduce the effectiveness of drugs metabolized in the liver (including coumarin derivatives, griseofulvin, glucocorticosteroids, oral contraceptives): enhances action of local anesthetic, analgesic and hypnotic drugs.

    The drug increases the toxicity of methotrexate.

    The action of the drug is enhanced by the use of valproic acid preparations.
    Special instructions:

    The experience of using the drug in children under 18 years is absent.

    During the use of the drug should not drink alcohol.

    Effect on the ability to drive transp. cf. and fur:

    The preparation contains phenobarbital, so patients taking Corvalol should refrain from driving and other potentially dangerous activities that require increased concentration and speed of psychomotor reactions.

    Form release / dosage:Pills.
    Packaging:

    For 10, 20 or 25 tablets in a contour mesh box (blister) made of polyvinylchloride film and aluminum foil printed lacquered.

    For 1, 2, 3, 4, 5 or 10 blisters, together with instructions for medical use, are placed in a cardboard pack.
    For 30, 50, 100 blisters together with an equal number of instructions for medical use are placed in a cardboard box (for hospitals).
    Storage conditions:

    In the dark place at a temperature of no higher than 25 aboutFROM.

    Keep out of the reach of children.

    Shelf life:2 years. Do not use after the expiration date.
    Terms of leave from pharmacies:Without recipe
    Registration number:LP-003881
    Date of registration:05.10.2016
    Expiration Date:05.10.2021
    The owner of the registration certificate:YUZHFARM, LLC YUZHFARM, LLC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp18.01.2018
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