Kudesan - instructions for use, doses, side effects, contraindications

Active substanceUbidecarenoneUbidecarenone

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Kudesan® for children

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RUSFIK, LLC Russia

Dosage form: & nbspdrops for oral administration

Composition:

1 ml of the preparation contains:

Active substance: ubidecarenone - 30 mg.

Excipients: alpha-tocopherol acetate 4.5 mg, ascorbyl palmitate 1.0 mg, macrogol glyceryl hydroxy stearate (Cremophor RH-40) 105.0 mg, sodium benzoate 2.0 mg, citric acid (food) 1.6 mg, purified water up to 1 ml.

Description:

Transparent liquid is yellowish-orange in color with light opalescence.

Pharmacotherapeutic group:Cardiotonic agent of non-glycosidic structure

ATX: & nbsp

C.01.E.X Other combination drugs for the treatment of heart disease

C.01.E.X.09 Ubidecarenone

Pharmacodynamics:

Ubidekarenone (coenzyme Q10, ubiquinone) is a natural substance that is a vitamin-like coenzyme. Ubidecarenone is an endogenous substrate, takes part in the transfer of electrons in the transport chain of oxidation-reduction processes, in the process of energy exchange, in the reaction of oxidative phosphorylation in the respiratory chain of mitochondria of cells. Participates in the processes of cellular respiration, increasing the synthesis of adenosine triphosphate (ATP). Has a clinically significant antioxidant effect.Protects the lipids of cell membranes from peroxidation. Reduces the area of damage to the myocardium under conditions of ischemia and reperfusion. Ubidecarenone prevents elongation QT interval, improves the tolerance of exercise. Due to endogenous synthesis 100% satisfaction of the body's need for coenzyme Q10 occurs only up to the age of 20 years. Concentration of coenzyme Q10 decreases in elderly patients, as well as in various diseases in both adults and children.

Indications:

- As part of complex therapy:

In adults: chronic heart failure, dilated cardiomyopathy, ischemic heart disease, including myocardial infarction (during the period of restorative therapy), arrhythmias, hypertension.

In children from 1 year: chronic heart failure, dilated cardiomyopathy, arrhythmias, chronic gastroduodenitis, chronic pyelonephritis, metabolic nephropathy, migraine, neuro-circulatory dystonia, hereditary neurodegenerative diseases (mitochondrial encephalomyopathy (MELAS syndrome), Leig's syndrome, tuberous sclerosis), congenital myopathies, muscular dystrophies, diseases,associated with the violation of metabolic processes (asthenic syndrome, recovery period after severe diseases and surgical interventions).

- The period of preparation for cardiac surgery (coronary artery bypass grafting, congenital and acquired defects) in adults and children from 1 year on the recommendation of a doctor.

- To improve the adaptation to increased physical exertion in adults and children from 1 year.

- For prevention and replacement of coenzyme deficiency Q10 in adults and children from 1 year.

Contraindications:

Hypersensitivity to the components of the drug. Children up to 1 year.

Carefully:

With arterial hypotension.

Pregnancy and lactation:

The drug is not recommended for pregnant and lactating women due to lack of sufficient clinical experience.

Dosing and Administration:

The drug Couesan® should be taken orally 1 time per day during meals in the morning, previously dissolved in a small amount of boiled water or other beverages at room temperature. With the aim of preventing and replenishing the deficiency of coenzyme Q10 take in accordance with the recommendations in Table 1.

Table 1

Age	Drops, mean appointment	Equivalent content of coenzyme Q10, mg
1 year - 3 years	2-4 drops	3-6 mg
3 years - 7 years	4-8 drops	6-12 mg
7-12 years old	8-12 drops	12-18 mg
Children over 12 years and adults	12-24 drops	18-30 mg

In the complex treatment of various diseases, Couesan® is administered according to age for all reported indications in accordance with the recommendations set forth in Table 2.

table 2

Age	Drops, mean appointment	Equivalent content of coenzyme Q10, mg
1 year - 3 years	4-10 drops	6-15 mg
3 years - 7 years	10-16 drops	15-24 mg
7-12 years old	16-20 drops	24-30 mg
Children over 12 years and adults	20-60 drops	30-90 mg

The duration of the course of the drug Kudesan® is 2-3 months. Repeated courses - on the advice of a doctor.

Side effects:

Allergic reactions are possible. Very rarely: nausea, diarrhea.

Overdose:No data.

Interaction:

Simultaneous use of lipid-lowering agents (statins, fibrates), beta-blockers (atenolol, metoprolol, propranolol), tricyclic antidepressants, can lead to a decrease in the concentration of ubidecarenone in the blood plasma.

Ubidekarenone can reduce the effect of warfarin.

Ubidekarenone can potentiate the action of diltiazem, metoprolol, enalapril and nitrates.

Effect on the ability to drive transp. cf. and fur:

No data.

Form release / dosage:

Drops for oral administration 3%.

Packaging:

For 15, 20, 25, 50, 60, 100 ml in bottles of light-protective (orange) glass, equipped with polyethylene stoppers, droppers and screw caps.

Each bottle together with the instruction for use is placed in packs of cardboard.

Storage conditions:

Store in a dark place at a temperature of 15 to 25 ° C.

Keep out of the reach of children.

Shelf life:

2 years. Do not use after the expiration date.

Terms of leave from pharmacies:Without recipe

Registration number:LSR-003092/10

Date of registration:12.04.2010 / 26.09.2013

Expiration Date:Unlimited

The owner of the registration certificate:VNESHTORG PHARMA, LLC VNESHTORG PHARMA, LLC Russia

Manufacturer: & nbsp

VNESHTORG PHARMA, LLC Russia

Representation: & nbspRUSFIK LLC RUSFIK LLC Russia

Information update date: & nbsp06.02.2018

Illustrated instructions

Instructions

Coudesan® (Kudesan)