Kudevita - instructions for use, dose, side effects, contraindications

- in the substance-mixture mixture "ALL-QUE (Coenzyme Q10) 10% CWS / S": medium chain triglycerides 12.0 mg, modified food starch 156.0 mg, sucrose 51.0 mg, corn starch 51.0 mg;

- other: talc 1.5 mg, potato starch 4.5 mg; Hard gelatin capsules No. 1 (composition of capsules: titanium dioxide 2%, gelatin to 100%).

Description:

Hard gelatinous capsules number 1 white. The contents of the capsules are light-orange with white impregnations.

Pharmacotherapeutic group:Cardiotonic agent of non-glycosidic structure

ATX: & nbsp

C.01.E.X Other combination drugs for the treatment of heart disease

C.01.E.X.09 Ubidecarenone

Pharmacodynamics:

Ubidekarenone (coenzyme Q10, ubiquinone) is a natural substance that is a vitamin-like coenzyme. Ubidecarenone is an endogenous substrate, takes part in the transfer of electrons in the transport chain of oxidation-reduction processes, in the process of energy exchange,in the reaction of oxidative phosphorylation in the respiratory chain of mitochondria cells. Participates in the processes of cellular respiration by increasing the synthesis of adenosine triphosphate. Has a clinically significant antioxidant effect. Protects the lipids of cell membranes from peroxidation, preventing the formation of free radicals, thereby slowing down the aging process.

Reduces the area of damage to the myocardium under conditions of ischemia and reperfusion. Ubidecarenone does not extend the QT interval, improves the tolerance of exercise. Due to endogenous synthesis 100% satisfaction of the body's need for coenzyme Q10 occurs only up to the age of 20 years. Concentration of coenzyme Q10 decreases in elderly patients, as well as in various diseases in both adults and children.

Pharmacokinetics:

The maximum concentration is an average of 0.7 μg / ml after oral administration of a dose of 120 mg. Time to reach the maximum concentration in the blood plasma - 7 hours after ingestion The half-life period is 3.5 hours. With prolonged use (from 4 to 12 weeks) cumulates, mainly in the liver and heart.

Indications:

Prevention in the complex therapy of various diseases of the cardiovascular system:

Coronary heart disease, chronic heart failure (NYHA class II-III functional class);
Arterial hypertension;
Myocardial infarction (during the period of reconstructive therapy);
The period of preparation for cardiac surgery (coronary artery bypass grafting, with heart defects).

Prevention and as part of a comprehensive therapy for migraine.

For prevention and replacement of coenzyme Q10 deficiency.

To improve the adaptation to increased physical exertion in athletes.

Contraindications:

Hypersensitivity to the components of the drug;
acute glomerulonephritis;
peptic ulcer of the stomach and duodenum (in the stage of exacerbation);
severe bradycardia (heart rate less than 50 beats per minute);
age up to 12 years;
fructose intolerance and glucose / galactose absorption disorder or sugarase / isomaltase deficiency.

If you have any of these diseases, consult a doctor before taking the drug.

Carefully:

Arterial hypotension.

Pregnancy and lactation:

The drug is not recommended for pregnant and lactating women due to lack of sufficient clinical experience.

Dosing and Administration:

For the prevention of taking all the stated indications for adults and children over 12 years of 30 mg (1 capsule) per day after meals in the morning.

In the complex therapy in the treatment of chronic heart failure and ischemic heart disease, 150 mg (5 capsules) are prescribed, divided into 3-5 meals a day after meals.

In the complex therapy of arterial hypertension, myocardial infarction (during recovery therapy), in preparation for cardiac surgery (coronary artery bypass grafting, with heart defects), migraine, to compensate for coenzyme Q10 deficiency and improve adaptation to increased physical exertion in athletes, adults and children over 12 years are prescribed from 30 mg (1 capsule) to 90 mg (3 capsules) per day.

The duration of the course of the drug is 1-3 months. Increase the duration of the course of therapy and repeat courses - on the advice of a doctor.

Side effects:

Possible allergic reactions (skin rash, itching), nausea, diarrhea, heartburn, epigastric pain.

If any of the side effects listed in the manual are aggravated, or if you notice any other side effects not listed in the instructions, tell your doctor.

Overdose:

Data on overdose are absent.

Interaction:

Simultaneous use of lipid-lowering agents (statins, fibrates), warfarin, beta-blockers (atenolol, metoprolol, propranolol), tricyclic antidepressants, can lead to a decrease in the concentration of ubidecarenone in the blood plasma.

Ubidekarenone can enhance the action of diltiazem, metoprolol, enalapril and nitrates.

Form release / dosage:

Capsules 30 mg.

Packaging:

For 10 or 15 capsules in a contour cell packaging.

3 or 6 contour mesh Packages of 10 capsules or 2 or 4 contourcell packings per 15 capsules together with instructions for use in a pack of cardboard.

Storage conditions:

In a dry, protected from light place at a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life:

2 years. Do not use after expiry date.

Terms of leave from pharmacies:Without recipe

Registration number:LP-000019

Date of registration:28.10.2010 / 23.11.2015

Expiration Date:Unlimited

The owner of the registration certificate:PIK-PHARMA, LLC PIK-PHARMA, LLC Russia

Manufacturer: & nbsp

PIC-PHARMA PRO, LLC Russia

Representation: & nbspPIK-PHARMA LLC PIK-PHARMA LLC Russia

Information update date: & nbsp06.02.2018

Illustrated instructions

Instructions

Kudevita® (Kudevite)