Lactulose + Lignin hydrolysis (Lactulosum + Ligninum hydrolisatum)

Pharmacodynamics Pharmacokinetics Indications Carefully Contraindications Dosing and Administration Side effects
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Clinical and pharmacological group: & nbsp

Laxatives

Included in the formulation
  • Lactofiltrum®
    pills inwards 
    AVVA RUS, OJSC     Russia
    • АТХ:

    A.06.A.D   Laxative preparations with osmotic properties

    A.06.A.D.61   Lactulose in combination with other drugs

    Pharmacodynamics:

    Lactulose

    Stimulates peristalsis of the large intestine and reproduction of lactic acid bacteria. Under the influence of the microflora of the large intestine lactulose hydrolyzed to lactic and partially to acetic and formic acids. In the intestine, the pH changes to the acidic side, the osmotic pressure rises, which results in the retention of ammonium ions, the migration of ammonia into the large intestine, followed by ionization. The concentration of ammonium ions in plasma is reduced by 25-50%, which normalizes the parameters of the electroencephalogram and improves the mental state.

    Hypoammonemic effect is observed after the development of laxative action of the drug - in 24-48 hours after administration.

    Lignin

    Lignin consists of products of hydrolysis of wood components, has a nonspecific detoxification effect and high absorbent activity. In the intestine binds pathogenic bacteria, toxins, heavy metal salts, allergens, alcohol, as well as excess bilirubin, cholesterol, histamine, urea and metabolites that cause endogenous toxicosis.

    Pharmacokinetics:

    Absorption of the components of lactulose is weak - up to 3%.

    Lignin is not absorbed and removed from the intestine within 24 hours.

    Indications:

    It is used for acute and chronic diseases of the gastrointestinal tract, dyspeptic disorders, diarrhea, dysbiosis.

    It is used to treat acute diseases accompanied by intoxication syndrome, with toxicosis of pregnant women, liver failure with encephalopathy.

    Used to adjust the stool with constipation, as well as to prepare for operations on the rectum.

    ICD-10

    XI.K20-K31.K30   Dyspepsia

    XI.K70-K77.K74   Fibrosis and cirrhosis of the liver

    XI.K70-K77.K72   Hepatic failure, not elsewhere classified

    Contraindications:
    • Galactosemia.
    • Intestinal obstruction.
    • Suspicion of organic lesions of the gastrointestinal tract.
    • Rectal bleeding.
    • Individual intolerance.

    Carefully:Stomach ulcer and duodenal ulcer, diabetes mellitus.
    Pregnancy and lactation:

    Recommendations for FDA - Category B. The drug has no systemic effect, is used for pregnant and lactating women.

    Dosing and Administration:

    Use in children

    1-3 years: 0.5 tablets 3 times a day;

    3-7 years: 1 tablet 3 times a day;

    8-12 years: 1-2 tablets 3 times a day.

    Adults

    Inside for 1 hour before meals 2-3 tablets 3 times a day.

    The highest daily dose: 9 tablets.

    The highest single dose: 3 tablets.

    Side effects:

    Digestive system: flatulence, a feeling of discomfort in the abdomen.

    Metabolism: violation of electrolyte balance during long-term treatment with high doses of hepatic encephalopathy.

    Allergic reactions.

    Overdose:Symptoms: abdominal pain, diarrhea.

    Treatment: cancellation of the drug.

    Interaction:Nonabsorbed antacids and neomycin reduce the effect of lactulose.
    Special instructions:

    To avoid flatulence in the presence of gastrocardial syndrome, the dose of the drug increases gradually.

    With prolonged treatment for hepatic encephalopathy, monitoring of the level of blood electrolytes is necessary.

    When taking a drug for people with diabetes, you need to adjust the dose of sugar-reducing drugs.

    Instructions
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