Lavakol® (Lavacole®)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceMacrogolMacrogol
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    • Dosage form: & nbspPOral solution for oral administration.
    Composition:Per package:

    Active substance:

    Macrogol 4000 (Polyethylene glycol 4000)

    12.0 g

    Excipients:

    Sodium sulfate (Sodium sulfate)

    1.0 g

    Sodium bicarbonate (Sodium bicarbonate)

    0.6 g

    Sodium chloride

    0.2 g

    Potassium chloride

    0.2 g

    14.0 grams
    Description:

    Powder white or white with a yellowish or grayish hue of color. One packet of the drug is dissolved in 200 ml of water. The resulting solution is a colorless or slightly colored liquid, slight opalescence is allowed.

    Pharmacotherapeutic group:laxative
    ATX: & nbsp

    A.06.A.D.15   Macrogol

    Pharmacodynamics:

    Pharmacological properties

    Osmotic laxative.A high-molecular substance, which is a long linear polymer, which by means of hydrogen bonds is capable of retaining water molecules. Increases the osmotic pressure and volume of the intestinal fluid, enhancing peristalsis. Increases the volume of chyme, prevents the loss of electrolytes with feces. Restores the reflex of evacuation, does not change pH chyme.

    Pharmacodynamics

    The effect of the drug is based on the combination of a high molecular weight polymer with an isotonic solution of electrolytes. Macrogol prevents the absorption of water from the stomach and intestines and facilitates the accelerated evacuation of intestinal contents by frequent defecations. Electrolytes contained in the preparation, interfere with the violation of the water-electrolyte balance of the body.

    Pharmacokinetics:

    Pharmacokinetic studies confirm the absence of macrogol absorption and metabolism when ingested.

    Indications:Preparation for endoscopic or radiographic examination of the colon, as well as for surgical interventions requiring the absence of contents in the intestine.
    Contraindications:

    Hypersensitivity to macrogol or any of the auxiliary substances that make up the drug, dehydration, chronic heart failure, stomach ulcer, intestinal obstruction, perforation or risk of perforation of the intestinal wall, severe inflammatory bowel disease, violation of gastric emptying (including gastroparesis) , children under 18 years of age (efficacy and safety not established).

    Carefully:

    Ulcerative colitis, patients with impaired swallowing reflex, reflux esophagitis, oppression of consciousness, renal dysfunction, propensity to develop water-electrolyte imbalance, neurologic disorders, impaired motor function, propensity to aspiration, pregnancy, elderly age.

    Pregnancy and lactation:

    The use of the drug during pregnancy is possible if the expected benefit for the mother exceeds the potential risk to the fetus (due to insufficient data to assess the effect of macrogol on the fetus).

    Because the macrogol is not absorbed from the gastrointestinal tract, application of the drug during breastfeeding is possible in agreement with the attending physician.

    Dosing and Administration:

    Inside. To adults.

    The contents of the package (14.0 g) are dissolved in 200 ml of water. Is taken orally on an empty stomach for 18-20 hours before the examination or surgery.

    The solution is taken in a dosage of 1 liter per 15-20 kg of body weight (approximately 200 ml with an interval of 20 minutes). During the reception and after it only liquid food is consumed. Recommended hours of taking the drug are 14.00-19.00.

    After 10 pm, food is not shown.

    Side effects:

    From the digestive system: sensation of anterior abdominal wall stretching, abdominal pain, nausea, diarrhea; vomiting, strong urge to defecate, fecal incontinence, irritation of the perianal area, flatulence.

    Allergic reactions: urticaria, skin itch, skin rash, swelling of the face, Quincke's edema, anaphylactic shock, lightning and acute pulmonary edema.

    If any of the side effects indicated in the manual are aggravated, or if you notice any other side effects not listed in the instructions, tell your doctor!
    Overdose:

    Exceeding the dose can lead to disruption of the water-electrolyte balance, to the development of diarrhea, which, as a rule, stops on its own 1-2 days after the drug is discontinued.

    Interaction:

    Diarrhea caused by the drug Lavakol®, can lead to a violation of absorption of other concomitant medications. In the case of concurrent administration of Lavakol® with other drugs, it is recommended that it be administered 2 hours after they are taken.

    Simultaneous reception of macrogol and digoxin leads to a decrease in the degree of absorption of the latter in the intestine.

    Special instructions:

    For elderly patients with various concomitant diseases, the drug is recommended for use under medical supervision.

    The patient should be warned about the need to inform the doctor about all concomitant medications.

    In the case of diarrhea, special control and monitoring of electrolyte blood composition is necessary in patients prone to the development of electrolyte disorders.

    It is recommended to use the drug with caution in patients with ulcerative colitis due to the high risk of perforation.

    Effect on the ability to drive transp. cf. and fur:

    Given the possibility of developing unwanted reactions, care should be taken when driving vehicles and working with mechanisms.

    Form release / dosage:

    Powder for solution for oral administration, 12 g.

    Packaging:

    14.0 grams in heat-sealable bags of material combined on the basis of aluminum foil or from packaging material combined on a paper basis.

    For 5, 10, 15 or 20 bags, together with instructions for use, are placed in a pack of cardboard.

    Packing for hospitals

    For 150, 300 or 500 packages, together with an equal number of instructions for use, are placed in boxes of corrugated cardboard.

    Storage conditions:

    Store in a dry place, at a temperature not exceeding 25 FROM.

    Keep out of the reach of children.

    Shelf life:

    5 years.

    Do not use the drug after the expiration date.

    Terms of leave from pharmacies:Without recipe
    Registration number:LS-000443
    Date of registration:18.05.2010 / 09.06.2016
    Expiration Date:Unlimited
    The owner of the registration certificate:MOSCOW PHARMACEUTICAL FACTORY, CJSC MOSCOW PHARMACEUTICAL FACTORY, CJSC Russia
    Manufacturer: & nbsp
    Representation: & nbspMOSCOW PHARMACEUTICAL FACTORY MOSCOW PHARMACEUTICAL FACTORY Russia
    Information update date: & nbsp23.11.2016
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