Lidevin (Lidevine)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Dosage form: & nbsppills
Composition:

Active substances: disulfiram - 500 mg, nicotinamide (vitamin B3) - 0.3 mg, adenine (vitamin B4) - 0.5 mg.

Auxiliary substancesa: povidone, microcrystalline cellulose, carmellose sodium, magnesium stearate.

Description:Round, Valium pills white with Valium a color shade with the possible inclusions, beveled on one side of the cross-shaped risk.
Pharmacotherapeutic group:Alcoholism treatment
ATX: & nbsp
  • Disulfiram
    • Pharmacodynamics:

    The effect of the drug is based on the blockade of acetaldehyde dehydrogenase, which is involved in the metabolism of ethyl alcohol. This leads to increased concentrations of the metabolite of ethanol - acetaldehyde, which causes negative feelings (flushing, nausea, vomiting, tachycardia, low blood pressure (BP), etc.), which make it extremely unpleasant alcohol after taking Lidevina. This leads to a conditioned reflex aversion to the taste and smell of alcoholic beverages. Maximum therapeutic effect is achieved within 12 hours after oral administration, and may continue for 10-14 days after cessation of treatment.

    Combination of disulfiram with vitamins. The combination of disulfiram with vitamins B3 and B4 provides a pronounced clinical effect on taking even small doses of alcohol, has minimal side effects, reduces the toxicity of disulfiram, provides prevention of alcoholic polyneuropathy and hypovitaminosis.

    Pharmacokinetics:

    After oral administration, the absorption of disulfiram from the gastrointestinal tract (GIT) is from 70 to 90%. It is rapidly metabolized, recovering to dithiocarbamate, which itself is excreted as a glucuron-conjugate or converted to diethylamine and carbon sulphide, some of which (4-53%) is excreted through the lungs.

    Indications:

    Treatment and prevention of recurrences of chronic alcoholism.

    Contraindications:
    Absolute: diseases of the cardiovascular system in the stage of decompensation, hearing organs (neuritis of the auditory nerve) and eyes (glaucoma, optic neuritis); bronchial asthma, emphysema; pulmonary tuberculosis, severe hepatic insufficiency, hematopoietic diseases, diabetes mellitus, thyrotoxicosis, epilepsy and convulsive syndrome of any genesis, mental illness, exacerbation of peptic ulcer, kidney disease, evilquality tumors, polyneuritis of any etiology, pregnancy, increased individual sensitivity to the drug.

    Relative: cardiovascular diseases in the compensation stage, elderly age (over 60 years), gastric ulcer and 12 duodenal ulcer in remission, residual phenomena after cerebral circulation disturbance, previously transferred teturam (antabuse) psihoShl.

    Carefully:Lidevin should be taken with caution in patients with renal insufficiency and hypothyroidism, especially at the risk of a possible combination with alcohol.
    Dosing and Administration:

    Treatment is appointed after careful examination of the patient and warning of the consequences and complications.

    The drug is taken orally 125-500 mg twice a day according to the individual scheme (the calculation of the dose is carried out in terms of disulfiram).

    After 7-10 days, disulfiramidalcohol test (20-30 ml of 40% vodka after taking 500 mg of the drug); with a weak reaction, the dose of alcohol is increased by 10-20 ml (the maximum dose of vodka is 100-120 ml). The sample is repeated after 1-2 days in the hospital and 3-5 daysshe is outpatient with a correction of the doses of alcohol and / or the drug as needed.

    In the future, you can use a maintenance dose of 125-200 mg per day for 1-3 years.

    Side effects:

    Conditioned by the properties of disulfiram:

    - Metal taste in the mouth.

    - Unpleasant odor in patients with colostomy (associated with carbon sulphide).

    - Rare cases of hepatitis, sometimes found in patients with nickel eczema, not suffering from alcoholism.

    - Polyneuropathy of the lower extremities, optic neuritis.

    - Memory loss, confusion, astenorI.

    - Headache.

    - Skin allergic manifestations.

    Coupled with the combination of disulfiram-ethyl alcohol:

    - Cases of respiratory failure are described; cardiovascular collapse, heart rhythm disturbances, angina pectoris, sometimes myocardial infarction, as well as neurological disorders; swelling of the brain.

    Complications with long-term admission: rarely - psychoses resembling alcoholic; hepatitis, gastritis; in persons suffering from cardiovascular diseases, thrombosis of the cerebral vessels is possible; therefore, if complaints are made regarding paresthesia in the limbs and face, immediately discontinue the drug; aggravation of polyneuritis.

    When taking doses of alcohol over 50-80 ml of vodka against the background of Lidevin, severe cardiovascular and respiratory system disorders, edema, convulsions develop. In this case, urgently carry out detoxification therapy, inject analeptics, perform symptomatic treatment.
    Overdose:

    The combination with ethanol can cause depression of consciousness up to a coma, a cardiovascular collapse, neurological complications.

    Treatment symptomatic.

    Interaction:

    Contraindicated combinations:

    - Alcohol. The reaction of intolerance (hot flushes, erythema, vomiting, tachycardia).

    Avoid taking alcohol and medications containing alcohol.

    Unwanted combinations:

    - Isoniazid. Violations of the conductthe and coordination.

    - Nitro-5-imidazoles (metronidazole, ordinazole, secnidazole, tinidazole). Delirious disorders, confusion.

    - Phenytoin. Significant and rapid rise in the level of phenytoin in the plasma with toxic symptoms (suppression of its metabolism).

    If the combination can not be avoided, clinical monitoring and control of plasma concentrations of the drug should be performed during and after Lidevin treatment.

    Combinations that require caution:

    - Warfarin (and other oral anticoagulants). The increased effect of oral anticoagulants and the risk of bleeding (reduced warfarin degradation in the liver).It is recommended more frequent monitoring of the concentration of warfarin and correction of the dose of anticoagulants within 8 days after Lidevin's withdrawal.

    - Theophylline. Lidevin inhibits theophylline metabolism. As a result, the dose of theophylline should be adjusted (reduced dosage), depending on the clinical symptoms and the concentration of the drug in the plasma.

    - Benzodiazepines. Disulfiram can potentiate the sedative effect of benzodiazepines by inhibiting their oxidative metabolism (especially chlordiazepoxide and diazepam). The dosage of benzodiazepine should be adjusted in accordance with clinical manifestations.

    - Tricyclic antidepressants. It is possible to intensify the reaction of alcohol intolerance (especially if patients are on the background of taking Lidevin, take alcohol).

    Special instructions:Patients should be warned about the dangers of alcohol intolerance reaction.
    Form release / dosage:Pills.
    Packaging:In blisters for 10 pieces.

    2 blisters with instructions for use in a cardboard bundle.

    Storage conditions:

    Store at a temperature not exceeding 25 ° C.

    Keep out of the reach of children.

    Shelf life:

    3 years.

    Do not use the product after the expiry date printed on the package.

    Terms of leave from pharmacies:On prescription
    Registration number:П N012889 / 01
    Date of registration:02.04.2007
    Expiration Date:Unlimited
    The owner of the registration certificate:Laboratory of TradafarLaboratory of Tradafar France
    Manufacturer: & nbsp
    Representation: & nbspSazhefarm, Open CompanySazhefarm, Open Company
    Information update date: & nbsp28.02.2018
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